With the rapid development of modern information technology, students’ education and computer technology begin to blend, and the modern teaching mode is quite different from the traditional education mode known in the past. In view of the current college English teaching in the information age, this study puts forward the way of integrating computer information technology with college English teaching, improves MLP algorithm, puts forward a new artificial intelligence algorithm, improves its calculation efficiency, and uses the optimized GA-MLP-NN (Genetic Neural Network Algorithm for the Multilayer Perceptron) algorithm in college students’ oral correction program. Firstly, GA-MLP-NN algorithm is used to optimize college English teaching so that more complex structures can be learned and dealt with. Incremental hidden layer unit neural network is added, which makes the operation more accurate based on S-type recursive function. Then, the oral English system is established, using the GA-MLP-NN neural network model. Finally, we evaluate the parameters of the model, design a comparative experiment and a questionnaire survey to verify the rationality and feasibility of the guess, which proves that this method can deal with more complex programs, and make students learn English more handy and close to students’ needs by using computer technology.