The chapter discusses the importance of integrating business principles into nursing leadership to improve healthcare delivery. It highlights the need for nurse leaders to be knowledgeable in strategic planning, financial management, human resources, and organizational behavior. The chapter highlights the need for a holistic approach that includes both clinical and business competencies. Key business domains include financial stewardship, strategic management, and human resource management. It also discusses the role of healthcare economics, policy implications, and data analytics in performance improvement. The chapter advocates for the incorporation of business education in nursing curricula and ongoing professional development to cultivate a new generation of nurse leaders capable of thriving in complex healthcare environments.