Advancements in information and communication technologies (ICT), big data analytics, and artificial intelligence- (AI-) based techniques brought a dramatic revolution in diverse research domains, including healthcare, IoT, and networking. Blockchain technologies are gaining traction from both private and government organizations at an incredible rate. Emerging technologies have different levels of technological complexities and commercial ramifications. This technology is playing an essential role in the financial revolution of banking and regulatory sectors. Blockchain has piqued the interest of many academics, organizations, and businesses, particularly in using bitcoin. To grasp the significance of this revolution, a comprehensive assessment is performed to bridge the gaps in the targeted blockchain-driven domain with different perspectives. For this systematic review process, a set of four distinct research questions were formulated to accumulate the most relevant research trends. In private and public organizations, it is a securing technology to deliver trustworthy and protected services to users because of its decentralized, controlled aspect. Financial services, real estate, supply chain management, healthcare, academics, and other industries benefit significantly from this evolutionary technology. These application cases are diverse and far-reaching, ranging from smart contracts to blockchain-encrypted educational certificates. This systematic analysis has investigated a total of 113 relevant articles and concluded with the features and functions in an economic setting and briefed how these variables can balance players’ incentives, define core blockchain-related features, and present new research ideas to solve the proposed risk.