Buspirone: A Worldwide Update

Napoliello, Michael J.; Domantay, A. G.

doi:10.1192/s0007125000296232

“…Buspirone is an anxiolytic that has been in clinical use for some years. It has presynaptic agonistic and postsynaptic partial agonistic properties at the 5-HT 1A -receptor (for further description, see Napoliello and Domantay. 1991).…”

Section: Introductionmentioning

confidence: 99%

Citalopram as an Inhibitor of Voluntary Ethanol Intake in the Male Rat

Hedlund¹,

Wahlström²

1998

Alcohol

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Psychological dependence was induced in rats by a 1-year intermittent exposure to intoxicating doses of ethanol, and recorded by the rat's ability to later take the same dose of ethanol independent of the offered concentration. Citalopram (10 or 40 mg/kg/day) was given for 3 weeks with ethanol available only the first and the last day; 10 mg/kg had no effect. On the first treatment day 40 mg/kg decreased ethanol intake. On the last treatment day 40 mg/kg had no effect. The following week the ethanol intake was higher than before the treatment in the 40 mg/kg group. During the four posttreatment weeks the ethanol intake of the 40 mg/kg group dropped significantly. Citalopram was retested 18 weeks after the first treatment during 1 week, with continuous access to ethanol; 10 mg/kg had no effect and 40 mg/kg decreased ethanol intake at day 1, reaching a minimum in day 3. A tolerance to this effect was seen at the end of the week. Thus, in this model an acute dose of citalopram can decrease ethanol intake, but tolerance to this effect develops when citalopram is given both with and without access to ethanol.

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“…The delayed onset of Alcohol ClIn Exp Res, Vol 23, No 5, 1999: pp 822-827 action of the anxiolytic effect (Napoliello and Domantay, 1991) means at least a 2-week treatment period before this effect can be evaluated, with a drug that has effects on ethanol intake that are not presently well understood.…”

mentioning

confidence: 99%

Acute and Long Term Effects of Buspirone Treatments on Voluntary Ethanol Intake in a Rat Model of Alcoholism

Hedlund

¹

,

Wahlström

²

1999

Alcoholism Clin & Exp Res

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Buspirone, a 5-HT1A agonist, has been shown to decrease the intake of ethanol when given as a single dose to rats with a psychological dependence induced according to our rat model of alcoholism. The present experiment evaluates the effects different treatments with buspirone have on voluntary ethanol intake in these psychologically dependent rats. As a first treatment, buspirone was given once daily for 23 days at the dose of 20 mg/kg/day. Ethanol was withheld except for the first and the last day of the treatment. On the first day, the buspirone injection decreased ethanol intake from the pretreatment value (1.94+/-0.18 g/kg/day), down to 1.36+/-0.18 g/kg (p < 0.01, n = 12). The rats were again given a choice between water and 10% ethanol after the last injection of buspirone. During the following 24 hr period, the ethanol intake was increased to 3.56+/-0.24 g/kg/day (p < 0.001 vs. the pretreatment intake, n = 12). A loss of correlation with the pretreatment intake of ethanol indicated an altered regulation of ethanol intake for approximately 3 more weeks. Fifteen weeks after the start of the first treatment, buspirone (20 mg/kg) was re-tested as a single dose, with no effect on ethanol intake. Twenty-two weeks after the start of the first treatment, a 1-week treatment with 20 mg/kg/day of buspirone was started. During this treatment, the rats had a continuous choice between 10% ethanol and water. There was, as in the first re-test, no effect on ethanol intake on the first day of the treatment. However, on the last 2 days of the treatment, the ethanol intake was increased to 2.86+/-0.28 g/kg and to 2.89+/-0.26 g/kg respectively (p < 0.05, n = 10 on both days, compared with the pretreatment intake of 1.78+/-0.36 g/kg). Thus, an acute dose of buspirone can decrease voluntary ethanol intake in psychologically dependent rats, but long-lasting changes in the effect of buspirone seem to develop during a 3-week treatment period.

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“…Buspirone is an anxiolytic drug with mainly presynaptic agonistic and postsynaptic partial agonistic properties at the 5-HTl A-receptors (Napoliello and Domantay, 1991). Clinical trials have shown a beneficial effect of buspirone after ethanol withdrawal, especially in anxious alcoholics (Bruno, 1989;Tollefson et al, 1992;Olivera et al, 1990;Kranzler and Meyer, 1989).…”

mentioning

confidence: 99%

“…One reason to carefully establish the effects of buspirone on ethanol intake, beside its potential usefulness in the treatment of alcoholism, is that buspirone is given to alcoholics for the treatment of anxiety. The delayed onset of action of the anxiolytic effect (Napoliello and Domantay, 1991) means at least a 2-week treatment period before this effect can be evaluated, with a drug that has effects on ethanol intake that are not presently well understood.…”

mentioning

confidence: 99%

Acute and Long Term Effects of Buspirone Treatments on Voluntary Ethanol Intake in a Rat Model of Alcoholism

Hedlund¹,

Wahlstr??m²

1999

Alcoholism: Clinical & Experimental Research

0

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Buspirone, a 5-HT1A agonist, has been shown to decrease the intake of ethanol when given as a single dose to rats with a psychological dependence induced according to our rat model of alcoholism. The present experiment evaluates the effects different treatments with buspirone have on voluntary ethanol intake in these psychologically dependent rats. As a first treatment, buspirone was given once daily for 23 days at the dose of 20 mg/kg/day. Ethanol was withheld except for the first and the last day of the treatment. On the first day, the buspirone injection decreased ethanol intake from the pretreatment value (1.94+/-0.18 g/kg/day), down to 1.36+/-0.18 g/kg (p < 0.01, n = 12). The rats were again given a choice between water and 10% ethanol after the last injection of buspirone. During the following 24 hr period, the ethanol intake was increased to 3.56+/-0.24 g/kg/day (p < 0.001 vs. the pretreatment intake, n = 12). A loss of correlation with the pretreatment intake of ethanol indicated an altered regulation of ethanol intake for approximately 3 more weeks. Fifteen weeks after the start of the first treatment, buspirone (20 mg/kg) was re-tested as a single dose, with no effect on ethanol intake. Twenty-two weeks after the start of the first treatment, a 1-week treatment with 20 mg/kg/day of buspirone was started. During this treatment, the rats had a continuous choice between 10% ethanol and water. There was, as in the first re-test, no effect on ethanol intake on the first day of the treatment. However, on the last 2 days of the treatment, the ethanol intake was increased to 2.86+/-0.28 g/kg and to 2.89+/-0.26 g/kg respectively (p < 0.05, n = 10 on both days, compared with the pretreatment intake of 1.78+/-0.36 g/kg). Thus, an acute dose of buspirone can decrease voluntary ethanol intake in psychologically dependent rats, but long-lasting changes in the effect of buspirone seem to develop during a 3-week treatment period.

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Buspirone: A Worldwide Update

Cited by 38 publications

References 25 publications

Citalopram as an Inhibitor of Voluntary Ethanol Intake in the Male Rat

Citalopram as an Inhibitor of Voluntary Ethanol Intake in the Male Rat

Acute and Long Term Effects of Buspirone Treatments on Voluntary Ethanol Intake in a Rat Model of Alcoholism

Acute and Long Term Effects of Buspirone Treatments on Voluntary Ethanol Intake in a Rat Model of Alcoholism

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