Buspirone along with melatonin attenuates oxidative damage and anxiety-like behavior in a mouse model of immobilization stress

Kumar, Anil; Kaur, Gurleen; Rinwa, Puneet

doi:10.1016/s1875-5364(14)60089-3

Cited by 18 publications

(17 citation statements)

References 31 publications

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“…Our results showed that the level of oxidative stress markers (MDA& ROS) was increased compared with model group, whether in serum or the amygdala. Consistent with the general conclusion (Kumar et al 2014, Shahzad et al 2014, the oxidative stress damage is also an important pathogenesis of anxiety.…”

Section: Discussionsupporting

confidence: 87%

Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway

Ying

Yao

et al. 2019

Appl. Physiol. Nutr. Metab.

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Schisandrin B (Sch B), one of Fructus Schisandrae's main effective components, protects neurons from oxidative stress in the central nervous system. Here we investigated the neuroprotective effect of Sch B in the acute oxidative stress damage and attempted to define the possible mechanisms. From the elevated plus maze (EPM) and open field test (OFT), we found that forcing swimming, an acute stressor, significantly induced anxiety-like behavior which was alleviated by Sch B (p.o.) treatment. In addition, the Sch B treatment suppressed toxicity, malondialdehyde (MDA) and reactive oxygen species (ROS), an important factor for neuron damage. The antioxidant molecules under the control of Nrf2 pathway, such as superoxide dismutase (SOD) and glutathione (GSH), were significantly increased by Sch B treatment. Moreover, a higher percentage of intact cells in the amygdala further verified the neuroprotective effect of Sch B in Nissl staining. Several proteins such as Nrf2 and its endogenous inhibitor Keap1, were abnormal expressed in force swimming mice but were significantly reversed by Sch B treatment. Herein, our results suggested that Sch B may be a potential therapeutic agent against anxiety disease that is associated with oxidative stress. The possible mechanism is attributed to its neuroprotection through enhancing antioxidant effect.

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Section: Discussionsupporting

confidence: 87%

Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway

Ying

Yao

et al. 2019

Appl. Physiol. Nutr. Metab.

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“…Estrogens administered to ovariectomized rats have an effect on the period length and onset of locomotor activity (Krizo and Mintz, 2014). Photoperiod and melatonin, the major hormone in the circadian rhythm, is implied in the modulation of anxiety in rodents (Golombek et al, 1996; Nava and Carta, 2001; Trainor et al, 2007; Bilu and Kronfeld-Schor, 2013; Adamah-Biassi et al, 2014; Kumar et al, 2014; Nagy et al, 2014), possibly mediated by interaction with the GABAergic system (Golombek et al, 1996). Taken together, the observed effects on genes related to the circadian rhythm in female brain might represent a plausible connection to the stress sensitive behavior phenotype.…”

Section: Discussionmentioning

confidence: 99%

Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior

Porseryd

Volkova

Caspillo

et al. 2017

Front. Behav. Neurosci.

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The synthetic estrogen 17α-ethinylestradiol (EE2) is an endocrine disrupting compound of concern due to its persistence and widespread presence in the aquatic environment. Effects of developmental exposure to low concentrations of EE2 in fish on reproduction and behavior not only persisted to adulthood, but have also been observed to be transmitted to several generations of unexposed progeny. To investigate the possible biological mechanisms of the persistent anxiogenic phenotype, we exposed zebrafish embryos for 80 days post fertilization to 0, 3, and 10 ng/L EE2 (measured concentrations 2.14 and 7.34 ng/L). After discontinued exposure, the animals were allowed to recover for 120 days in clean water. Adult males and females were later tested for changes in stress response and shoal cohesion, and whole-brain gene expression was analyzed with RNA sequencing. The results show increased anxiety in the novel tank and scototaxis tests, and increased shoal cohesion in fish exposed during development to EE2. RNA sequencing revealed 34 coding genes differentially expressed in male brains and 62 in female brains as a result of EE2 exposure. Several differences were observed between males and females in differential gene expression, with only one gene, sv2b, coding for a synaptic vesicle protein, that was affected by EE2 in both sexes. Functional analyses showed that in female brains, EE2 had significant effects on pathways connected to the circadian rhythm, cytoskeleton and motor proteins and synaptic proteins. A large number of non-coding sequences including 19 novel miRNAs were also differentially expressed in the female brain. The largest treatment effect in male brains was observed in pathways related to cholesterol biosynthesis and synaptic proteins. Circadian rhythm and cholesterol biosynthesis, previously implicated in anxiety behavior, might represent possible candidate pathways connecting the transcriptome changes to the alterations to behavior. Further the observed alteration in expression of genes involved in synaptogenesis and synaptic function may be important for the developmental modulations resulting in an anxiety phenotype. This study represents an initial survey of the fish brain transcriptome by RNA sequencing after long-term recovery from developmental exposure to an estrogenic compound.

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“…Also, we can mention here the study of Kumar group, which used an immobilization stress animal model of anxiety and proved that the six-hour time spent in restraint could considerably increase the brain concentrations of lipid peroxidation markers and nitrite in the animals. Furthermore, the same anxiety model had important effects on brain glutathione and catalase rates which were significantly decreased compared to the control group [ 105 ].…”

Section: Oxidative Stress Implications In Some Animal Models Of Afmentioning

confidence: 99%

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

Balmus

Ciobîcă

Antioch

et al. 2016

Oxidative Medicine and Cellular Longevity

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The correlation between the affective disorders and the almost ubiquitous pathological oxidative stress can be described in a multifactorial way, as an important mechanism of central nervous system impairment. Whether the obvious changes which occur in oxidative balance of the affective disorders are a part of the constitutive mechanism or a collateral effect yet remains as an interesting question. However it is now clear that oxidative stress is a component of these disorders, being characterized by different aspects in a disease-dependent manner. Still, there are a lot of controversies regarding the relevance of the oxidative stress status in most of the affective disorders and despite the fact that most of the studies are showing that the affective disorders development can be correlated to increased oxidative levels, there are various studies stating that oxidative stress is not linked with the mood changing tendencies. Thus, in this minireview we decided to describe the way in which oxidative stress is involved in the affective disorders development, by focusing on the main oxidative stress markers that could be used mechanistically and therapeutically in these deficiencies, the genetic perspectives, some antioxidant approaches, and the relevance of some animal models studies in this context.

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Buspirone along with melatonin attenuates oxidative damage and anxiety-like behavior in a mouse model of immobilization stress

Cited by 18 publications

References 31 publications

Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway

Schisandrin B alleviates acute oxidative stress via modulation of the Nrf2/Keap1-mediated antioxidant pathway

Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

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