Buspirone prevents sexual motivation in depressed male mice from reduction

Amikishieva, A.; Августинович, Д. Ф.; Koryakina, L. A.

doi:10.1016/s0924-977x(01)80440-5

Cited by 4 publications

(2 citation statements)

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“…This behavioral reaction, in turn, stimulates the production of an additional amount of TS, which supports the developing behavior. The data on positive correlation between the parameters of contact with the female during the first 10 min of the test and subsequent level of TS in the blood confirm this hypothesis [6].…”

Section: Resultssupporting

confidence: 62%

Testosterone and behavior: Involvement of the hormone in psychotropic effects of baclofen

Amikishieva

2007

Bull Exp Biol Med

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We studied the effect of baclofen (GABA(B) receptor agonist) on the behavior of male mice with different levels of anxiety in tests for social and sexual contact and on blood testosterone levels. The drug reduced testosterone level and behavioral reaction to an unknown male in intact animals and did not modulate the hormone level and social contacts in anxious mice. In the test with receptive female, baclofen reduced testosterone level and sexual motivation in intact males and did not modulate the hormone level and initial sexual interest in anxious mice. Parallelism in the development of behavioral and endocrine components of the reaction to social and sexual stimuli confirms possible involvement of testosterone in psychotropic effects of baclofen.

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Section: Resultssupporting

confidence: 62%

Testosterone and behavior: Involvement of the hormone in psychotropic effects of baclofen

Amikishieva

2007

Bull Exp Biol Med

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“…There is a parallel interaction between anxiety and sexual behaviour. Anxious male mice exhibit reduced sexual motivation and treatment with anxiolytic agents exerts a corrective effect on sexual interest in depressed mice . In men, anxiety‐related disorders occur in tandem with sexual dysfunction .…”

Section: Discussionmentioning

confidence: 99%

Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice

Adekunbi

Lass

et al. 2018

J Neuroendocrinology

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The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is, however, limited information available on the specific neuronal cell type in the MePD functionally mediating these behaviours in rodents. The recent discovery of a significant kisspeptin neurone population in the MePD has raised interest in the possible role of kisspeptin and its cognate receptor in sexual behaviour. The present study therefore tested the hypothesis that the MePD kisspeptin neurone population is involved in regulating attraction towards opposite sex conspecifics, sexual behaviour, social interaction and the anxiety response by selectively stimulating these neurones using the novel pharmacosynthetic DREADDs (designer receptors exclusively activated by designer drugs) technique. Adult male Kiss‐Cre mice received bilateral stereotaxic injections of a stimulatory DREADD viral construct (AAV‐hSyn‐DIO‐hM3D(Gq)‐mCherry) targeted to the MePD, with subsequent activation by i.p. injection of clozapine‐N‐oxide (CNO). Socio‐sexual behaviours were assessed in a counter‐balanced fashion after i.p. injection of either saline or CNO (5 mg kg‐1). Selective activation of MePD kisspeptin neurones by CNO significantly increased the time spent by male mice in investigating an oestrous female, as well as the duration of social interaction. Additionally, after CNO injection, the mice appeared less anxious, as indicated by a longer exploratory time in the open arms of the elevated plus maze. However, levels of copulatory behaviour were comparable between CNO and saline‐treated controls. These data indicate that DREADD‐induced activation of MePD kisspeptin neurones enhances both sexual partner preference in males and social interaction and also decreases anxiety, suggesting a key role played by MePD kisspeptin in sexual motivation and social behaviour.

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Effects of baclofen on anxiety, sexual motivation, and olfactory perception in male mice in different psychoemotional states

Amikishieva

Semendyaeva

2007

Neurosci Behav Physiol

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The psychotropic effects of the GABA(B) receptor agonist baclofen (1, 2.5, and 5 mg/kg, i.p.) on anxiety, sexual motivation, and olfactory perception were studied in male mice in different psychoemotional states. Baclofen decreased the rate of perception (analysis) of olfactory stimuli. The effects of baclofen on behavior depended on the psychoemotional state of the animals. In intact males, baclofen administration had an anxiolytic effect in the elevated plus-maze (EPM) and social contacts tests and increased responses to males. In aggressive males, baclofen administration had anxiolytic effects in the EPM and restored levels of sexual motivation to the control level. In submissive males, baclofen administration had weak influences on anxiety levels in both tests, but prevented waning of sexual interest. The presence and absence of parallels in the development of anxiety and sexual reactions in animals in different social states are discussed.

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Buspirone prevents sexual motivation in depressed male mice from reduction

Cited by 4 publications

References 0 publications

Testosterone and behavior: Involvement of the hormone in psychotropic effects of baclofen

Testosterone and behavior: Involvement of the hormone in psychotropic effects of baclofen

Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice

Effects of baclofen on anxiety, sexual motivation, and olfactory perception in male mice in different psychoemotional states

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