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Experiments were performed to compare the behavior of male and female mice of the inbred strains CBA/Lac and C57BL/6J in the open field test after single episodes of severe stress imposed by forced swimming. Testing was performed 2 h (first test) and one day (second test) after stress. Control animals were intact males and females of these strains, and were also tested in the open field on two sequential days. Both male and female CBA/Lac mice showed increases in the latent period of excursions from the center of the field 2 h after stress. This change persisted to the second test in female CBA/Lac mice. In female C57BL/6J mice, there were changes in four of seven behavioral measures 2 h after stress, though at one day their behavior was as in control individuals. Stress had virtually no effect in males of this strain, only increasing the number of grooming acts in the first test. In addition, detailed analysis of the effects of repeat testing in control and stressed individuals of these mouse strains also revealed interstrain and gender-related differences in the effects of stress. The possible existence of increased basal (trait) and situational (state) anxiety in female C57BL/6J and CBA/Lac mice respectively is discussed.

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