Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress

Августинович, Д. Ф.; Alekseyenko, Olga V.; Koryakina, L. A.

doi:10.1016/s0024-3205(02)02414-1

Cited by 17 publications

(9 citation statements)

References 29 publications

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“…These results indicate that comparisons of consequences of different chronic stress forms should only be performed after a long (3 weeks) period. Our results are in line with those of Avgustinovich et al. (2003) who found that only a long period (20 days) of social defeat stress causes a depression‐like behavior.…”

Section: Discussionsupporting

confidence: 93%

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Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression

Haenisch

Bilkei-Gorzó

Caron

et al. 2009

Journal of Neurochemistry

104

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Diverse factors such as changes in neurotrophins and brain plasticity have been proposed to be involved in the actions of antidepressant drugs (ADs). However, in mouse models of depression based on chronic stress, it is still unclear whether simultaneous changes in behavior and neurotrophin expression occur and whether these changes can be corrected or prevented comparably by chronic administration of ADs or genetic manipulations that produce antidepressant‐like effects such as the knockout of the norepinephrine transporter (NET) gene. Here we show that chronic restraint or social defeat stress induce comparable effects on behavior and changes in the expression of neurotrophins in depression‐related brain regions. Chronic stress caused down‐regulation of BDNF, nerve growth factor, and neurotrophin‐3 in hippocampus and cerebral cortex and up‐regulation of these targets in striatal regions. In wild‐type mice, these effects could be prevented by concomitant chronic administration of five pharmacologically diverse ADs. In contrast, NET knock out (NETKO) mice were resistant to stress‐induced depressive‐like changes in behavior and brain neurotrophin expression. Thus, the resistance of the NETKO mice to the stress‐induced depression‐associated behaviors and biochemical changes highlight the importance of noradrenergic pathways in the maintenance of mood. In addition, these mice represent a useful model to study depression‐resistant behaviors, and they might help to provide deeper insights into the identification of downstream targets involved in the mechanisms of antidepressants.

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Section: Discussionsupporting

confidence: 93%

“…2007), chronic stress models such as chronic restraint stress (Kim and Han 2006) or chronic social defeat stress (Kudryavtseva and Avgustinovich 1998) seem to be the most promising. While 10‐day social defeat mainly produces anxiety, chronic social stress for 20 days leads to depression (Avgustinovich et al. 2003).…”

mentioning

confidence: 99%

Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression

Haenisch

Bilkei-Gorzó

Caron

et al. 2009

Journal of Neurochemistry

104

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“…The total number of arm entries and beam breaks represents locomotor activity while the percentage of time spent in open arms and percentage of entries into open arms is indicative of the anxiety profile, independent of the locomotor activity effect [14]. A significant increase in the percentage of time spent in open arms and percentage of entries into open arms was revealed in the mice treated with the anxiolytic Buspirone (1.0 mg/kg by ip) as previously reported by others [3]. …”

supporting

confidence: 68%

Behavioral evaluation of transgenic mice with CNS expression of IFN-α by elevated plus-maze and Porsolt swim test

Zhang

Tian

Wang

2010

Neuroscience Letters

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Chronic IFN-α treatment as an antiviral or anti-cancer therapy can lead to severe psychiatric complications, including depression and anxiety in patients. In many animal models of IFN-α-induced behavioral dysfunction, the opposite results have frequently been reported. In an attempt to overcome the limitation of pharmacological studies, IFN-α-transgenic mice with CNS-targeted expression of the IFN-α transgene were used to study depression- and anxiety-like behaviors by Porsolt swim and elevated plus-maze assays, respectively. Interestingly, chronic stimulation of IFN-α signaling in mouse brains did not cause depression or anxiety as measured by these tests in comparison with wild-type littermates. This observation suggests that factors other than IFN-α may be necessary for the development of psychiatric complications following IFN-α therapy in patients.

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“…The elevated plus maze test is the most used test for the selection of anxiolytic-like drug prototype (Han et al, 2009;Avgustinovich et al, 2003). This test is an animal model that uses natural stimuli such as fear of new, open and high spaces (Yu et al, 2007) as well as the preference for enclosed spaces.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, in rodent experimental models, this anxiolytic activity can be observed after an acute treatment, as observed in this study and, by Cao and Rodgers (1997), Young and Johnson (1991) and Peng et al (2004) that demonstrated the anxiolytic-like activity of buspirone, a 5-HT 1A partial agonist, in the elevated plus maze test and light-dark box tests after an acute treatment. Moreover, several reports in the literature have associated anxiolytic-like activity of piperazine derivatives to the involvement of serotoninergic pathway (Avgustinovich et al, 2003;Bojarski et al, 2006;Gray et al, 2009;Khatri et al, 2009;Paluchowska et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Central pharmacological activity of a new piperazine derivative: 4-(1-Phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester

et al. 2012

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Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress

Cited by 17 publications

References 29 publications

Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression

Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression

Behavioral evaluation of transgenic mice with CNS expression of IFN-α by elevated plus-maze and Porsolt swim test

Central pharmacological activity of a new piperazine derivative: 4-(1-Phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester

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