Effects of single episodes of severe stress on the behavior of male and female CBA/Lac and C57BL/6J mice

Августинович, Д. Ф.; Kovalenko, Irina; Koryakina, L. A.

doi:10.1007/s11055-007-0075-7

Cited by 8 publications

(3 citation statements)

References 24 publications

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“…1C, Supplementary Table 1); these two parameters were significantly higher in the BI-1 −/− mice relative to the wild-type mice, suggesting that knockout of BI-1 increases vulnerability to chronic mild stress. Forced swimming, which imposes high stress and evokes marked changes in physical and emotional components18, had a similar effect on swimming time in both BI-1 +/+ and BI-1 −/− stressed mice (Supplementary Fig. 3).…”

Section: Resultsmentioning

confidence: 74%

The protective role of Bax Inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A

Lee

Marahatta

et al. 2013

Sci Rep

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The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress. It has been hypothesized that BI-1 protects against neuron degenerative diseases. In this study, BI-1−/− mice showed increased vulnerability to chronic mild stress accompanied by alterations in the size and morphology of the hippocampi, enhanced ROS accumulation and an ER stress response compared with BI-1+/+ mice. BI-1−/− mice exposed to chronic mild stress showed significant activation of monoamine oxidase A (MAO-A), but not MAO-B, compared with BI-1+/+ mice. To examine the involvement of BI-1 in the Ca2+-sensitive MAO activity, thapsigargin-induced Ca2+ release and MAO activity were analyzed in neuronal cells overexpressing BI-1. The in vitro study showed that BI-1 regulates Ca2+ release and related MAO-A activity. This study indicates an endogenous protective role of BI-1 under conditions of chronic mild stress that is primarily mediated through Ca2+-associated MAO-A regulation.

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Section: Resultsmentioning

confidence: 74%

The protective role of Bax Inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A

Lee

Marahatta

et al. 2013

Sci Rep

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“…Compared to male rodents, female rodents are known to have greater corticosterone release under basal conditions [ 70 ] and in response to stress [ 71 – 74 ]. Female mice were shown to be more sensitive to unpredictable chronic mild stress [ 75 ], subchronic variable stress [ 76 ], and even acute stress [ 77 ]. Also, females have longer consequences of social defeat stress than males [ 78 , 79 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects

Bondar

Lepeshko

Reshetnikov

2018

Behavioural Neurology

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Stressful events in an early postnatal period have critical implications for the individual's life and can increase later risk for psychiatric disorders. The aim of this study was to investigate the influence of early-life stress on the social behavior of adult male and female mice. C57Bl/6 mice were exposed to maternal separation (MS, 3 h once a day) or handling (HD, 15 min once a day) on postnatal day 2 through 14. Adult male and female mice were tested for social behavior in the social interaction test and for individual behavior in the plus-maze and open-field tests. Female mice exposed to maternal separation had increased social behavior and increased anxiety. MS male mice had no changes in social behavior but had significantly disrupted individual behavior, including locomotor and exploratory activity. Handling had positive effects on social behavior in males and females and decreased anxiety in males. Our results support the hypothesis that brief separation of pups from their mothers (handling), which can be considered as moderate stress, may result in future positive changes in behavior. Maternal separation has deleterious effects on individual behavior and significant sex-specific effects on social behavior.

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“…42 However, studies are fundamentally inconsistent. A trend toward or significantly greater OF activity in female C57BL/6 mice is frequently reported, [43][44][45][46][47][48][49] but almost an equal number of other studies find no differences. [50][51][52][53][54][55] Inconsonant observations regarding sex differences could be the result of variations in specific testing conditions, such as lighting level, 56 or subtle aspects of the laboratory environment even when efforts are made to make conditions identical.…”

Section: Females Are More Active During the First Exposure To Open Fieldmentioning

confidence: 93%

Performance of Male and Female C57BL/6J Mice on Motor and Cognitive Tasks Commonly Used in Pre-Clinical Traumatic Brain Injury Research

Tucker

McCabe

2016

Journal of Neurotrauma

129

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To date, clinical trials have failed to find an effective therapy for victims of traumatic brain injury (TBI) who live with motor, cognitive, and psychiatric complaints. Pre-clinical investigators are now encouraged to include male and female subjects in all translational research, which is of particular interest in the field of neurotrauma given that circulating female hormones (progesterone and estrogen) have been demonstrated to exert neuroprotective effects. To determine whether behavior of male and female C57BL6/J mice is differentially impaired by TBI, male and cycling female mice were injured by controlled cortical impact and tested for several weeks with functional assessments commonly employed in pre-clinical research. We found that cognitive and motor impairments post-TBI, as measured by the Morris water maze (MWM) and rotarod, respectively, were largely equivalent in male and female animals. However, spatial working memory, assessed by the y-maze, was poorer in female mice. Female mice were generally more active, as evidenced by greater distance traveled in the first exposure to the open field, greater distance in the y-maze, and faster swimming speeds in the MWM. Statistical analysis showed that variability in all behavioral data was no greater in cycling female mice than it was in male mice. These data all suggest that with careful selection of tests, procedures, and measurements, both sexes can be included in translational TBI research without concern for effect of hormones on functional impairments or behavioral variability.

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Effects of single episodes of severe stress on the behavior of male and female CBA/Lac and C57BL/6J mice

Cited by 8 publications

References 24 publications

The protective role of Bax Inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A

The protective role of Bax Inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A

Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects

Performance of Male and Female C57BL/6J Mice on Motor and Cognitive Tasks Commonly Used in Pre-Clinical Traumatic Brain Injury Research

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