Effects of Haloperidol on Communicative and Aggressive Behavior in Male Mice with Different Experiences of Aggression

Kudryavtseva, N. N.; Lipina, Tatiana V.; Koryakina, L. A.

doi:10.1016/s0091-3057(98)00227-5

Cited by 31 publications

(23 citation statements)

References 21 publications

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“…Administration of the dopamine precursor L-dopa to Arctic charr (Salvelinus alpinus) increase aggressive behaviors and social dominance (Winberg and Nilsson, 1992). This result was in general agreement with evidence in lizards, birds, and mammals that increased dopamine is associated with aggressive behaviors, while dopamine receptor antagonists have been studied for their potential to reduce aggression (Dennis et al, 2006;Höglund et al, 2005;Kudryavtseva et al, 1999;Miczek et al, 2002;Schwartzer et al, 2009;van Erp and Miczek, 2000). Consequently, we had hypothesized that haloperidol would impair the ability of male fathead minnows to successfully occupy and defend a breeding substrate compared with a control male.…”

Section: Behaviorsupporting

confidence: 82%

“…At present, the reason for the discrepant behavioral response in the fathead minnow compared with other reports in the literature is unclear. However, it has been noted that pharmacological sensitivity of dopamine receptors can be altered by the behavioral history of individuals and many of the antisphychotic drugs may interact with other targets in addition to dopamine receptors, making it difficult to specifically attribute their anti-aggressive properties to effects on dopamine (Kudryavtseva et al, 1999;Miczek et al, 2002). Consequently, there are other complexities that may modulate the effects of haloperidol on behavior.…”

Section: Behaviormentioning

confidence: 99%

“…For example, the dopaminergic system exerts inhibitory control over gonadotropin release from the pituitary (Dufour et al, 2005). It also plays a role in modulating social dominance and aggressive behavior in fish and other vertebrates (Dennis et al, 2006;Höglund et al, 2005;Kudryavtseva et al, 1999;Schwartzer et al, 2009;Winberg and Nilsson, 1992). There has long been evidence that exposure to a wide variety of environmental contaminants can alter the abundance of neurotransmitters, such as dopamine, and various components of their associated neurotransmission systems, which may in turn lead to human disease, behavioral disorders, etc.…”

Section: Introductionmentioning

confidence: 99%

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II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish

Villeneuve

García-Reyero

Martinović

et al. 2010

Ecotoxicology and Environmental Safety

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a b s t r a c tNeurotransmitters such as dopamine play an important role in reproductive behaviors and signaling. Neuroendocrine-active chemicals in the environment have potential to interfere with and/or alter these processes. A companion study with the dopamine 2 receptor antagonist, haloperidol, found no evidence of a direct effect of the chemical on fish reproduction. This study considered haloperidol's potential effects on behavior and ovarian gene expression. Male fathead minnows exposed to 50 mg haloperidol/L for 96 h were found to be significantly more dominant than control males. In terms of molecular signaling, investigated using oligonucleotide microarrays, there was little similarity in the identity and functions of genes differentially expressed in the ovaries of fathead minnows (Pimephales promelas) versus zebrafish (Danio rerio) exposed under the same conditions. Results suggest that non-lethal concentrations of haloperidol do not induce ovarian molecular responses that could serve as biomarkers of exposure to D2R antagonists, but may impact behavior.Published by Elsevier Inc.

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Section: Behaviorsupporting

confidence: 82%

Section: Behaviormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish

Villeneuve

García-Reyero

Martinović

et al. 2010

Ecotoxicology and Environmental Safety

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“…Previous studies have indicated that drugs or manipulations that affect dopaminergic activity alter both the acoustic startle reflex (23) and intermale aggression (24)(25)(26)(27). We therefore measured the content of mono- Fig.…”

Section: Ptger1mentioning

confidence: 99%

Prostaglandin E receptor EP1 controls impulsive behavior under stress

Matsuoka

Furuyashiki

Yamada

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

110

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Animals under stress take adaptive actions that may lead to various types of behavioral disinhibition. Such behavioral disinhibition, when expressed excessively and impulsively, can result in harm in individuals and cause a problem in our society. We now show that, under social or environmental stress, mice deficient in prostaglandin E receptor subtype EP1 (Ptger1 ؊/؊ ) manifest behavioral disinhibition, including impulsive aggression with defective social interaction, impaired cliff avoidance, and an exaggerated acoustic startle response. This phenotype was reproduced in wild-type mice by administration of an EP1-selective antagonist, whereas administration of an EP1-selective agonist suppressed electric-shockinduced impulsive aggression. Dopamine turnover in the frontal cortex and striatum was increased in Ptger1 ؊/؊ mice, and administration of dopaminergic antagonists corrected their behavioral phenotype. These results suggest that prostaglandin E2 acts through EP1 to control impulsive behavior under stress, a finding potentially exploitable for development of drugs that attenuate impulsive behavior in humans.dopamine ͉ aggression ͉ behavioral disinhibition A ll organisms are repeatedly disturbed or threatened by changes in the internal or external environment. Such a state of perturbed homeostasis is referred to as ''stress'' (1, 2). Stress results not only from physical stimuli, such as heat, injury, or disease but also from psychological stimuli, such as exposure to a novel environment or a predator. Stress manifests itself in various characteristic responses that include emotions such as fear and aggression and activation of the neuroendocrine and sympathetic nervous systems (3). These stress responses are thought to be initiated and regulated in the CNS by biochemical processes that are evoked by threatening stimuli (''stressors'') and that determine the activity of several distinct but interacting neuronal pathways (4). However, the neural mechanisms responsible for initiation and regulation of stress responses have remained largely unknown. Neither is it known whether different forms of stressors (for example, physical vs. psychological stimuli) mobilize the same or distinct mechanisms to initiate and regulate their stress responses. Given that the stress responses are elicited to promote adaptation, severe dysfunction of either initiation or regulation mechanisms can not only be a threat to survival, but can also result in various physiological, psychological, or even psychiatric disorders (3, 5).We have been studying the roles of prostaglandins (PGs) in various physiological and pathophysiological processes. PGs are arachidonic acid metabolites formed by the sequential actions of cyclooxygenase (COX) and respective synthases, and they include PGD 2 , PGE 2 , PGF 2␣ , PGI 2 , and thromboxane A 2 . PGs interact with eight types or subtypes of G protein-coupled receptors, including the PGD receptor, four subtypes of PGE receptor (EP1, EP2, EP3, and EP4, which are encoded respectively by the genes Ptger1...

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“…Experiments increasing extracellular levels of DA result in increased aggression, while the administration of DA antagonists decrease aggression (Kudryavtseva et al 1999;Sokolov and Cadet 2006). DA receptor knockout systems have also shown a reduced aggressive phenotype (Drago et al 1998;Miczek et al 2001).…”

Section: Introductionmentioning

confidence: 99%

The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice

2008

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Effects of Haloperidol on Communicative and Aggressive Behavior in Male Mice with Different Experiences of Aggression

Cited by 31 publications

References 21 publications

II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish

II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish

Prostaglandin E receptor EP1 controls impulsive behavior under stress

The rewarding effect of aggression is reduced by nucleus accumbens dopamine receptor antagonism in mice

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