Butyl paraben and propyl paraben modulate bisphenol A and estradiol concentrations in female and male mice

Pollock, Tyler; Weaver, Rachel E.; Ghasemi, Ramtin; deCatanzaro, Denys

doi:10.1016/j.taap.2017.04.001

Cited by 53 publications

(18 citation statements)

References 66 publications

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“…Moreover, as urinary BP increases with the progress of pregnancy, it is presumed that the metabolism of BP is also influenced by physiological alteration during pregnancy . It is also known that BP is closely related to the metabolism of endocrine disruptors such as BPA, which is known to adversely affect placental development . To our knowledge, this is the first report identifying the effects of BP on the trophoblast cells that develop into the placenta.…”

Section: Discussionmentioning

confidence: 83%

“…As BP is widely contained in various beauty products, women of childbearing age are easily exposed to it, but the risk is not reported due to its relatively low content and toxicity. However, a recent study of BP‐induced histopathological or proteomic changes in the female reproductive organs of animal models suggested that the accumulation of BP may affect offspring . Based on this study, it is necessary to identify the adverse effects of BP, which accumulates in the placenta during pregnancy, and to study its stability.…”

Section: Discussionmentioning

confidence: 99%

“…BP increases expression of the estrogen receptor in estrogen receptor‐positive breast cancer cells, but not in normal breast epithelial cells . Moreover, recent research found that BP modulates BPA in female and male reproductive organs by exerting estrogenic effects . Furthermore, the level of BP in the urine of pregnant women is associated with oxidative stress .…”

Section: Introductionmentioning

confidence: 99%

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Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress‐induced endoplasmic reticulum stress

Yang

Lim

Bazer

et al. 2018

Environmental Toxicology

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Butyl paraben (BP) has antimicrobial effects and is widely used as a preservative in cosmetics, foods, and pharmaceuticals. It is also absorbed into various tissues of the human body. It is known that BP is measurable in maternal and fetal tissues during pregnancy, but the effects of BP on placental development, essential for maintaining normal pregnancy, are unclear. Therefore, we investigated the effect of BP on the proliferation, apoptosis, and invasiveness of human trophoblast cells, using an HTR8/SVneo cell line. BP inhibited cell proliferation and induced both apoptosis and endoplasmic reticulum stress. In addition, BP promoted the production of intracellular reactive oxygen species, increased Ca concentration in HTR8/SVneo cells, and induced mitochondrial membrane depolarization. BP also inhibited the activation of PI3K/AKT pathways including AKT, ribosomal protein S6, P70 S6 kinase, and glycogen synthase kinase 3β. Furthermore, pretreatment of cells with LY294002 (an AKT inhibitor) and U0126 (ERK1/2 inhibitor) revealed that ERK1/2 activity is also involved in BP-mediated signal transduction in HTR8/SVneo cells. We therefore suggest that exposing human trophoblast cells to BP diminishes normal physiological activity, leading to apoptosis and problems with early placental development.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress‐induced endoplasmic reticulum stress

Yang

Lim

Bazer

et al. 2018

Environmental Toxicology

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“…However, the tested doses are very high, whereas, on the contrary, very low doses correspond to the real exposure, often leading to small differences on the level of tissue and cell, without any demonstration of clinical aspects. Although changes in hormonal balance are well-known [60,61], EDs are even capable of affecting hormonal action directly in a cell without a shift in hormonal profile. Therefore, the estrogen-like and estrogenic effects of BPA have been described in germ [62], ovarian [63], and testicular cells [64,65].…”

Section: Molecular Mechanism Of Eds In Extremely Low Dosesmentioning

confidence: 99%

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Ješeta¹,

Nevoral²

2020

Male Reproductive Health

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Endocrine disruptors (EDs) are chemical substances that affect physiological processes in the body via hormonal regulation. They are often detected in food, plastic water bottles, cosmetics, and many other daily need items. Thereafter, EDs are detected in many bodily fluids, pointing out the real exposure to even very low doses. Permanent and long-term utilization of EDs has harmful effects on male reproductive health mainly due to interference with sex hormone synthesis and mechanism of action. However, with decreasing dosage of EDs, the possibilities of unpredictable modes of action arise. In addition to various molecular actions of individual EDs, the interference of individual ones represents another dimension of the ED issue. This review provides an overview of the EDs and their possible impact on reproductive health in males, with focus on sperm quality with the mighty potential of epigenetic transmission to further generations. The "posttranslational" effect of EDs in really low doses in real exposure routes is stigmatized in this review, being strongly considered as creeping molecular action of individual EDs as well as amplifications of their copresence in the environment.

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“…Fernandez et al (2016) published a statistically significant association between prenatal exposure to BPA and PP and the risk of male genital malformations. An even more recent study (Pollock et al 2017) showed that BP and PP can alter the pharmacokinetics of BPA, and that BP can modulate estradiol concentrations in an in vivo animal model. Taking into account the widespread occurrence of a variety of parabens and studies reporting associations between parabens and bisphenols, exploring the effects of these substances on the human body could occupy an entire scientific career.…”

Section: Endocrine Disruptor Interactionsmentioning

confidence: 99%

Prenatal Exposure to Bisphenols and Parabens and Impacts on Human Physiology

Kolátorová

Dušková²,

Vítků³

et al. 2017

Physiol Res

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In modern societies, living organisms are exposed daily to multiform pollution from industrial chemical products. Some of these substances have been shown to affect the endocrine system, and have been termed endocrine disruptors (EDs). Bisphenol A (BPA), which can leach from plastics, and parabens, used in cosmetic products, are among the most well-studied. Prenatal development is a vulnerable phase of human life, and disruptions during this period may have lifelong consequences. Since EDs are known to cross the placental barrier and BPA may accumulate in the fetus, “BPA-free” products have been introduced to the market. However, such products often contain alternative bisphenols (e.g. BPS, BPF) that have not yet been extensively examined or regulated. Moreover, alternative bisphenols often occur together with BPA. The human organism is thus exposed to a mixture of EDs, some of which can have additive or synergic effects. Recent findings have also shown that paraben exposure can alter bisphenol pharmacokinetics. Taking into account the widespread occurrence of various EDs and the potential multiplicity of their effects, doses of EDs currently considered safe may not actually be as safe as they appear, especially during pregnancy.

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Butyl paraben and propyl paraben modulate bisphenol A and estradiol concentrations in female and male mice

Cited by 53 publications

References 66 publications

Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress‐induced endoplasmic reticulum stress

Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress‐induced endoplasmic reticulum stress

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Prenatal Exposure to Bisphenols and Parabens and Impacts on Human Physiology

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