Butyl paraben-induced changes in DNA methylation in rat epididymal spermatozoa

Park, Chan Jin; Nah, Won Heum; Lee, J. E.; Oh, Yeong Seok; Gye, Myung Chan

doi:10.1111/j.1439-0272.2011.01162.x

Cited by 49 publications

(33 citation statements)

References 28 publications

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“…Parabens have weak estrogenic activity [56] and can induce proliferation of breast cancer cells [13]. In male rodents, butyl or propyl paraben exposure decreased sperm production, fetal testosterone, and/or epididymal weight [57, 58], and caused epigenetic changes in sperm [59]. …”

Section: Discussionmentioning

confidence: 99%

Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women

Hines

Mendola

Ehrenstein

et al. 2015

Reproductive Toxicology

162

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Phenols and parabens show some evidence for endocrine disruption in laboratory animals. The goal of the Methods Advancement for Milk Analysis (MAMA) Study was to develop or adapt methods to measure parabens (methyl, ethyl, butyl, propyl) and phenols (bisphenol A (BPA), 2,4- and 2,5-dichlorophenol, benzophenone-3, triclosan) in urine, milk and serum twice during lactation, to compare concentrations across matrices and with endogenous biomarkers among 34 North Carolina women. These non-persistent chemicals were detected in most urine samples (53-100%) and less frequently in milk or serum; concentrations differed by matrix. Although urinary parabens, triclosan and dichlorophenols concentrations correlated significantly at two time points, those of BPA and benzophenone-3 did not, suggesting considerable variability in those exposures. These pilot data suggest that nursing mothers are exposed to phenols and parabens; urine is the best measurement matrix; and correlations between chemical and endogenous immune-related biomarkers merit further investigation.

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Section: Discussionmentioning

confidence: 99%

Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women

Hines

Mendola

Ehrenstein

et al. 2015

Reproductive Toxicology

162

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“…In the study of Stouder et al [111] alcohol administration in pregnant mice induced hypomethylation of H19 imprinted gene and may have contributed to the decreased spermatogenesis. In another study [112], Park et al have shown that long-term exposure to butyl paraben (BP) can cause DNA hypermethylation from the mitotic through post-meiotic stage in adult rat testes.…”

Section: Epigenetic Modificationsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

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“…Higher paraben levels have been associated with reduced methylation at DMR2 of IGF2 in human placental tissue [75]. In the rat, postnatal exposure to butylparaben was shown to alter DNA methylation in sperm from F0 males, but no breeding was conducted to investigate transmission of an altered phenotype [92]. In an in vitro study, Pugazhendhi et al (2007) observed upregulation of MLL2 upon paraben treatment in MCF-7 cells [93].…”

Section: Bpa Phthalates and Parabens: Modes And Mechanisms Of Acmentioning

confidence: 99%

Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?

Xin

Susiarjo

Bartolomei

2015

Seminars in Cell & Developmental Biology

200

115

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Increasing evidence has highlighted the critical role of early life environment in shaping the future health outcomes of an individual. Moreover, recent studies have revealed that early life perturbations can affect the health of subsequent generations. Hypothesized mechanisms of multi- and transgenerational inheritance of abnormal developmental phenotypes include epigenetic misregulation in germ cells. In this review, we will focus on the available data demonstrating the ability of endocrine disrupting chemicals (EDCs), including bisphenol A (BPA), phthalates, and parabens, to alter epigenetic marks in rodents and humans. These epigenetic marks include DNA methylation, histone post-translational modifications, and non-coding RNAs. We also review the current evidence for multi- and transgenerational inheritance of abnormal developmental changes in the offspring following EDC exposure. Based on published results, we conclude that EDC exposure can alter the mouse and human epigenome, with variable tissue susceptibilities. Although increasing data suggest that exposure to EDCs is linked to transgenerational inheritance of reproductive, metabolic, or neurological phenotypes, more studies are needed to validate these observations and to elucidate further whether these developmental changes are directly associated with the relevant epigenetic alterations.

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Butyl paraben-induced changes in DNA methylation in rat epididymal spermatozoa

Cited by 49 publications

References 28 publications

Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women

Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women

Does air pollution play a role in infertility?: a systematic review

Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?

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