Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women

Hines, Erin P.; Mendola, Pauline; Ehrenstein, Ondine S. von; Ye, Xiaoyun; Calafat, Antònia M.; Fenton, Suzanne E.

doi:10.1016/j.reprotox.2014.11.006

Cited by 163 publications

(89 citation statements)

References 59 publications

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“…Parabens have been detected in human urine, serum, adipose tissue, milk, amniotic fluid and placental tissue [107][108][109][110][111][112][113], and in human breast cancer tissues [114,115]. In humans, dermal exposure to paraben-containing products is important for their absorption because some parabens penetrate the human skin [116]; the systemic absorption of parabens after environmental exposure has also been confirmed, although it seems to be a less important paraben source [38].…”

Section: Parabensmentioning

confidence: 98%

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

2017

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Cosmetic and personal care products are used in huge quantities throughout the world; as a result of their regular use, they are continuously released into the environment in very large amounts. Many of these products are biologically active and are characterized by persistence and bioaccumulation potential, posing a threat to ecosystem and human health. On the basis of the most recent scientific literature available on this subject, this paper provides an overview of some cosmetic ingredients that are considered environmental emerging pollutants of particular concern such as UV filters, some preservatives (parabens, triclosan), and microplastics.

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Section: Parabensmentioning

confidence: 98%

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

2017

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“…Studies also conducted in Spain [37][38][39] determined parabens in a range from 0.12 to 8.1 ng mL -1 , 0.9 to 21 ng mL -1 and from 0.7 to 18.6 ng mL -1 , respectively. Hines et al 35 determined parabens levels from 0.5 to 2.3 ng mL -1 . In the United States, 10 the average reported concentrations of parabens were 0.3-3.0 ng mL -1 .…”

Section: Concentration Of Parabens In Breast Milk Samples From Voluntmentioning

confidence: 99%

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Grecco¹,

Souza²,

Acquaro³

et al. 2018

J. Braz. Chem. Soc.

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A reliable method was developed and validated based on dispersive liquid-liquid microextraction (DLLME) and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) to determine simultaneously methylparaben (MePB), ethylparaben (EtPB), propylparaben (PrPB), and butylparaben (BuPB) in breast milk samples. A central composite design 2 4 with four independent variables and five levels of variance was used to optimize the DLLME conditions. The DLLME/UHPLC-MS/MS method was linear from 5 (lower limit of quantification, LLOQ) to 100 ng mL -1 (upper limit of quantification, ULOQ). The inter-assay and intra-assay precision values presented coefficients of variation (CVs) lower than 15%, and the relative standard error of the inter-and intra-assay accuracy values was lower than 10.4%. The DLLME/UHPLC-MS/MS method was successfully applied to determine parabens in human milk samples obtained from sixteen volunteer lactating mothers.

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“…However, limited partitioning information exists for environmental chemicals, and the use of PBDE concentrations in maternal blood as a surrogate for predicting maternal and infant exposure is still a developing field. The U.S. EPA (Environmental Protection Agency) Methods Advancement for Milk Analysis (MAMA) Study was initiated to better understand environmental chemical concentrations in women and the factors that influence chemical partitioning and infant exposure (Hines et al 2009, 2015). The objectives of the present study were to measure and compare concentrations of PBDEs in paired samples of serum and milk donated by women in the MAMA Study.…”

Section: Introductionmentioning

confidence: 99%

Polybrominated Diphenyl Ethers in Human Milk and Serum from the U.S. EPA MAMA Study: Modeled Predictions of Infant Exposure and Considerations for Risk Assessment

Marchitti

Fenton

Mendola

et al. 2017

Environ Health Perspect

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Background:Serum concentrations of polybrominated diphenyl ethers (PBDEs) in U.S. women are believed to be among the world’s highest; however, little information exists on the partitioning of PBDEs between serum and breast milk and how this may affect infant exposure.Objectives:Paired milk and serum samples were measured for PBDE concentrations in 34 women who participated in the U.S. EPA MAMA Study. Computational models for predicting milk PBDE concentrations from serum were evaluated.Methods:Samples were analyzed using gas chromatography isotope-dilution high-resolution mass spectrometry. Observed milk PBDE concentrations were compared with model predictions, and models were applied to NHANES serum data to predict milk PBDE concentrations and infant intakes for the U.S. population.Results:Serum and milk samples had detectable concentrations of most PBDEs. BDE-47 was found in the highest concentrations (median serum: 18.6; milk: 31.5 ng/g lipid) and BDE-28 had the highest milk:serum partitioning ratio (2.1 ± 0.2). No evidence of depuration was found. Models demonstrated high reliability and, as of 2007–2008, predicted U.S. milk concentrations of BDE-47, BDE-99, and BDE-100 appear to be declining but BDE-153 may be rising. Predicted infant intakes (ng/kg/day) were below threshold reference doses (RfDs) for BDE-99 and BDE-153 but above the suggested RfD for BDE-47.Conclusions:Concentrations and partitioning ratios of PBDEs in milk and serum from women in the U.S. EPA MAMA Study are presented for the first time; modeled predictions of milk PBDE concentrations using serum concentrations appear to be a valid method for estimating PBDE exposure in U.S. infants.Citation:Marchitti SA, Fenton SE, Mendola P, Kenneke JF, Hines EP. 2017. Polybrominated diphenyl ethers in human milk and serum from the U.S. EPA MAMA Study: modeled predictions of infant exposure and considerations for risk assessment. Environ Health Perspect 125:706–713; http://dx.doi.org/10.1289/EHP332

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Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women

Cited by 163 publications

References 59 publications

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

Cosmetic Ingredients as Emerging Pollutants of Environmental and Health Concern. A Mini-Review

Determination of Parabens in Breast Milk Samples by Dispersive Liquid-Liquid Microextraction (DLLME) and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry

Polybrominated Diphenyl Ethers in Human Milk and Serum from the U.S. EPA MAMA Study: Modeled Predictions of Infant Exposure and Considerations for Risk Assessment

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