2010
DOI: 10.1016/j.imbio.2010.01.001
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Butyrate in vitro immune-modulatory effects might be mediated through a proliferation-related induction of apoptosis

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Cited by 100 publications
(79 citation statements)
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“…We demonstrated that co-culture of adipocytes and Inflammatory leucocytes, including T-lymphocytes, were also reported to infiltrate visceral adipose tissues, which may contribute to local adipose tissue inflammation and insulin resistance in obese mice 40) . A low concentration of butyrate was reported to inhibit the proliferation of T-lymphocytes, and to induce apoptosis in activated T-lymphocytes, but not primary macrophages 41) . In the adipose tissue of obese mice, butyrate decreased infiltration by leukocytes 24) .…”
Section: Discussionmentioning
confidence: 98%
“…We demonstrated that co-culture of adipocytes and Inflammatory leucocytes, including T-lymphocytes, were also reported to infiltrate visceral adipose tissues, which may contribute to local adipose tissue inflammation and insulin resistance in obese mice 40) . A low concentration of butyrate was reported to inhibit the proliferation of T-lymphocytes, and to induce apoptosis in activated T-lymphocytes, but not primary macrophages 41) . In the adipose tissue of obese mice, butyrate decreased infiltration by leukocytes 24) .…”
Section: Discussionmentioning
confidence: 98%
“…Moreover, we and others [2,3] have seen previously that the sensitivity of HDAC inhibitors also depends on several factors, including the differentiation state, confluence, or proliferative rate of different cell types. Similarly to the authors, we have also addressed the relation between macrophage proliferation/viability/activation and HDAC effects [3]. In this regard, our previous data suggest that in those cells in which the activation stimuli do not affect proliferation, such as intestinal epithelial cells, or even induce proliferation, such as lymphocytes, butyrate (a pan-HDAC inhibitor) inhibits activation almost totally through the induction of apoptosis; in contrast, in those cells, such as bone marrow macrophages, whose activation induces a blockage of the proliferation, butyrate is unable to inhibit their activation and slightly affects cellular survival.…”
mentioning
confidence: 75%
“…Moreover, we and others [2,3] have seen previously that the sensitivity of HDAC inhibitors also depends on several factors, including the differentiation state, confluence, or proliferative rate of different cell types. Similarly to the authors, we have also addressed the relation between macrophage proliferation/viability/activation and HDAC effects [3].…”
mentioning
confidence: 75%
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“…In vitro studies have shown that butyrate regulates expression of genes that arrest growth and induces cellular differentiation. 11 Furthermore, in the HT-29 carcinoma cell line, butyrate inhibited proliferation and increased apoptosis but had no effect on the normal epithelial cell line, 12 suggesting that the action of SCFAs may depend on the state of activation of the target cells. Future studies should consider examining the effect of different SCFAs at different stages of IRI injury.…”
mentioning
confidence: 99%