Butyrylcholinesterase activity and metabolic syndrome in obese patients

Alcântara, Vânia M.; Oliveira, Lisangela Cristina de; Réa, Rosângela Roginski; Suplicy, Henrique Lacerda; Chautard‐Freire‐Maia, Eleidi A.

doi:10.1515/cclm.2005.048

Cited by 31 publications

(28 citation statements)

References 22 publications

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“…The BuChE was related to some general characteristics such as BMI and sex. The BuChE of men (9557.0 U/L) was significant higher than women (8143.0 U/L) workers (Independent sample t-test, p \ 0.01) which supported previous studies [10][11][12]. There was no significant correlation, in either men or women, with alcohol intake or smoking.…”

Section: Discussionsupporting

confidence: 86%

“…Venkata et al [18] found that pseudo-cholinesterase concentration decreased correspondingly and specifically with more functional liver cell damage. Other studies [19,20] found that plasma cholinesterase had relationship with triglycerides, HDL-C, and LDL-C. More recent reports [10,11,21,22] extended the association to wide range of variables with the metabolic syndrome including body mass index, apolipoprotein concentrations, insulin, liver enzymes, and blood pressure. Moreover, Nyblom et al [23] reported that the SGOT/ SGPT ratio can be used as an indicator of cirrhosis in alcoholic liver disease, hepatitis C and supported that the high ratio ([1.1) actually reflects cirrhotic changes in the liver.…”

Section: Discussionmentioning

confidence: 95%

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The Correlative Study of Serum Pseudo-cholinesterase, Biological Parameters and Symptoms Among Occupational Workers

2013

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Cholinesterase is one of many important enzymes needed for acetylcholine hydrolysis. This study aimed to evaluate the serum pseudo-cholinesterase (BuChE) level and its relation to biological parameters (hematological and biochemical parameters) and symptoms among occupational workers, gasoline station worker in Bangkok, Thailand. Our results revealed that the average BuChE level was in normal range, but it had strong relation to hemoglobin (Hb), hematocrit (Hct), blood urea nitrogen (BUN), creatinine (Cr) and serum glutamic pyruvic transaminase (SGPT) (Linear regression analysis, p \ 0.05, p \ 0.05, p \ 0.01, p = 0

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 95%

The Correlative Study of Serum Pseudo-cholinesterase, Biological Parameters and Symptoms Among Occupational Workers

2013

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“…Positive correlations of BMI (4,34) and MS (13) with BChEA, AC 4/5 and AC OF have also been reported.…”

Section: Butyrylcholinesterase and Diabetes Mellitusmentioning

confidence: 77%

“…In light of some of these correlations, Kutty and cols. (12) proposed the use of BChEA as a complementary risk factor for coronary artery disease (CAD), and also suggested the relationship of BChEA to metabolic syndrome (MS) (13).…”

Section: Introductionmentioning

confidence: 99%

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cwiertnia

Alcântara

Réa

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus. Subjects and methods: BChE activities (BChEA, AC 4/5 , AC OF and RC 5 ) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C 4/5 and C 5 complex were separated from other molecular forms (C OF ) using an acid agar gel. Results: The BChE activity (BChEA) and the absolute activities of C 4/5 (AC 4/5 ) and C OF (AC OF ) showed a high positive correlation coefficient to weight in the CHE2 C5-group, while the relative activity of C 5 complex (RC 5 ) showed a negative correlation to weight. Conclusions: The present study suggests that the positive correlation of the BChE activities to diabetes mellitus and to insulin resistance may depend on the CHE2 locus variability. High values of BChE activities were associated with insulin resistance only in CHE2 C5-diabetic patients, while in CHE2 C5+ diabetic patients, the presence of C 5 complex, especially in a relatively high proportion, leads to less fat storage and better protection against metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(1):60-7 Keywords BCHE and CHE2 loci; C 4/5 and C 5 complexes; obesity, insulin resistance; metabolic syndrome; serum cholinesterase RESUMO Objetivo: Investigar a associação entre as atividades (total e banda específica) da butirilcolinesterase (BChE) e diabetes melito. Sujeitos e métodos: As atividades da BChE (BChEA, AC 4/5 , AC OF e RC 5 ) foram analisadas em 101 pacientes diabéticos do tipo 1 (DM1) e 145 do tipo 2 (DM2) em relação aos fenótipos, ao peso e à incidência da síndrome metabólica. Os complexos C 4/5 e C 5 foram separados das outras formas moleculares (C OF ), usando gel de ágar ácido. Resultados: A atividade da BChE (BChEA) e as atividades absolutas de C 4/5 (AC 4/5 ) e de C OF (AC OF ) mostraram altos coeficientes de correlações positivos com peso no grupo de CHE2 C5-, enquanto a atividade relativa do complexo C 5 (RC 5 ) mostrou correlação negativa com o peso. Conclusões: O presente estudo sugere que as correlações positivas das atividades da BChE com diabetes melito e com a resistência à insulina podem depender da variabilidade do loco CHE2. Altos valores nas atividades da BChE estão associados com a resistência à insulina somente nos pacientes diabéticos CHE2 C5-, enquanto nos pacientes diabéticos CHE2 C5+ a presença do complexo C 5 , especialmente em alta proporção relativa, leva a um menor estoque de gordura e à maior proteção contra a síndrome metabólica. Arq Bras Endocrinol Metab. 2010;54(1):60-7 DescritoresLocos BCHE e CHE2; complexos C 4/5 e C 5 ; obesidade, resistência à insulina; síndrome metabólica; colinesterase do soro

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“…BChE has been proposed to be a marker of low-grade systemic inflammation, often seen in insulin resistance syndrome [29]. Although it may not play a causal role, BChE has been suggested to modulate its expression [30], or be a secondary marker [31]. The ability of high serum lipids to induce stereoscopic alteration in its configuration could be a pathogenic mechanism [32].…”

mentioning

confidence: 99%