Bypassing non-adherence via PEG in a critically ill HIV-1-infected patient

Leipe, Jan; Hueber, Axel J.; Rech, Juergen; Harrer, Thomas

doi:10.1080/09540120701767182

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…Data regarding the administration of antiretroviral medications using enteral feeding tubes are scarce. Three studies and nine case reports were identified . In an aforementioned study, bioequivalence of crushed versus intact elvitegravir, cobicistat, emtricitabine, and tenofovir coformulated tablets was demonstrated following oral administration in 24 healthy volunteers.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The majority of patients were treatment experienced: 5 adults and 15 children. Percutaneous endoscopic gastrostomy (PEG) tubes were the most common enteral feeding tubes used (Table ) . The rationale for using enteral tubes varied but included critical illness (two patients), gastrointestinal disease (two patients), HIV wasting (one patient), paraplegia (one patient), gastroparesis (one patient), taste aversion (two patients), difficulty swallowing (one patient), psychological aversion to swallowing pills (one patient), behavioral issues (four patients), and unspecified nonadherence to antiretroviral therapy (nine patients).…”

Section: Literature Reviewmentioning

confidence: 99%

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A HAART-Breaking Review of Alternative Antiretroviral Administration: Practical Considerations with Crushing and Enteral Tube Scenarios

et al. 2016

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Selection of an appropriate antiretroviral regimen for the patient infected with human immunodeficiency virus can be challenging, as various considerations must be taken into account including viral resistance mutations, patient comorbidities, drug interactions, and the potential for drug-related adverse effects and toxicities. Treatment is further complicated when a clinical scenario arises requiring an alteration in the dosage form. Factors ranging from dysphagia to administration through an enteral feeding tube can affect decisions regarding antiretroviral dosage forms. Limited pharmacokinetic data exist regarding the alteration of antiretroviral medications from their original form. Bioavailability may vary substantially between dosage forms, which can lead to unpredictable drug concentrations. Supratherapeutic or subtherapeutic antiretroviral drug concentrations can result in increased toxicity, virologic failure, or the emergence of drug resistance. We performed a systematic literature search to review the available antiretroviral literature on the modification of solid dosage forms as well as alternative routes of administration of oral antiretroviral agents and their application to clinical practice.

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Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

A HAART-Breaking Review of Alternative Antiretroviral Administration: Practical Considerations with Crushing and Enteral Tube Scenarios

et al. 2016

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Acute Care Management of the HIV‐Infected Patient: A Report from the HIV Practice and Research Network of the American College of Clinical Pharmacy

et al. 2017

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Treatment of hospitalized patients with HIV is highly complex. HIV-infected patients are at high risk for medication errors during various transitions of care. Baseline knowledge of the principles of antiretroviral pharmacotherapy is necessary for clinicians managing acutely ill HIV-infected patients to avoid medication errors, identify DDIs, and correctly dose medications if organ dysfunction arises. Timely ambulatory follow-up is essential to prevent readmissions and facilitate improved transitions of care.

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Abacavir Sulfate – Aminacrine: Aminacrine Hydrochloride (Aminoacridine Hydrochloride)

2018

Trissel’s Stability of Compounded Formulations, 6e

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Bypassing non-adherence via PEG in a critically ill HIV-1-infected patient

Cited by 7 publications

References 9 publications

A HAART-Breaking Review of Alternative Antiretroviral Administration: Practical Considerations with Crushing and Enteral Tube Scenarios

A HAART-Breaking Review of Alternative Antiretroviral Administration: Practical Considerations with Crushing and Enteral Tube Scenarios

Acute Care Management of the HIV‐Infected Patient: A Report from the HIV Practice and Research Network of the American College of Clinical Pharmacy

Abacavir Sulfate – Aminacrine: Aminacrine Hydrochloride (Aminoacridine Hydrochloride)

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