Bysspectin A, an unusual octaketide dimer and the precursor derivatives from the endophytic fungus Byssochlamys spectabilis IMM0002 and their biological activities

Wu, Yu-Zhuo; Zhang, Huawei; Sun, Zhao-Hui; Dai, Jungui; Hu, Youcai; Li, Rui; Lin, Peng-Cheng; Xia, Gui-Yang; Wang, Lingyan; Qiu, Bo-Lin; Zhang, Jingfang; Ge, Guangbo; Lin, Sheng

doi:10.1016/j.ejmech.2018.01.030

Cited by 38 publications

(20 citation statements)

References 45 publications

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“…The K i value of bakuchiol against CES2-mediated FD hydrolysis is 2.12 μmol/L and the inhibition type was non-competitive inhibition. Bysspectin A, a polyketide-derived octaketide dimer, displayed selective inhibitory effect on CES2-mediated FD hydrolysis 108 . Further investigation suggested that bysspectin A functioned as a competitive inhibitor against CES2, and the O -atom of the C-3′ phenolic or the O -atom at the funan ring could strongly interact with the Ser-288 (the key amino acid of the catalytic triad) of CES2 via hydrogen bonding.…”

Section: Ces Inhibitorsmentioning

confidence: 99%

Human carboxylesterases: a comprehensive review

Wang

Zou

Jin

et al. 2018

Acta Pharmaceutica Sinica B

391

268

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Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and environmental toxicants. The key roles of CES in both human health and xenobiotic metabolism arouse great interest in the discovery of potent CES modulators to regulate endobiotic metabolism or to improve the efficacy of ester drugs. This review covers the structural and catalytic features of CES, tissue distributions, biological functions, genetic polymorphisms, substrate specificities and inhibitor properties of CES1 and CES2, as well as the significance and recent progress on the discovery of CES modulators. The information presented here will help pharmacologists explore the relevance of CES to human diseases or to assign the contribution of certain CES in xenobiotic metabolism. It will also facilitate medicinal chemistry efforts to design prodrugs activated by a given CES isoform, or to develop potent and selective modulators of CES for potential biomedical applications.

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Section: Ces Inhibitorsmentioning

confidence: 99%

Human carboxylesterases: a comprehensive review

Wang

Zou

Jin

et al. 2018

Acta Pharmaceutica Sinica B

391

268

View full text Add to dashboard Cite

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“…Fonte: Wang et al,2000;Zhou et al, 2010;Wagenar et al, 2000;Wall et al,1966;Amrani et al, 2012;Wu et al, 2013;Song et al, 2004;Conti et al (2016);Perven et al (2017); Chowdhury et al (2017); Jinfeng et al (2017); Wu et al (2018). Campos et al (2008) verificaram que o extrato bruto do fungo endofítico Cochliobolus sp.…”

Section: Metabólitos Secundários Com Atividades Contra Doenças Negligmentioning

confidence: 99%

“…Muitos endofíticos ainda são capazes de fixar nitrogênio (BALDANI et al,1986;BARRAQUIO et al,1997;BODDEY et al, 2003;LOIRET et al, 2004;SANDHIYA et al, 2005;FONSECA et al, 2018), aumentar a captação de fósforo (GASONI; GURFMKEL, 1997;MALINOWSKI et al, 1999), promover o crescimento de plantas (PATLE et al, 2018), controle biológico (AMATUZZI et al, 2018). Wu et al (2018) isolaram do fungo endofítico Byssochlamys spectabilis, obtido da planta medicinal Chinesa Edgeworthia chrysantha, a bisspectina A, um dímero octacedídeo, as bisspectina B e C e a paecilocina A, um octacetídeo (Figura 2). As bisspectinas A-C apresentaram atividade antimicrobiana e a bisspectina A apresentou atividade inibidora altamente seletiva contra hCE2 (carboxilesterases humana) com IC50 de 2.01 µM.…”

Section: Metabólitos Secundários Com Atividade Antibiótica Isolados Dunclassified

Microrganismos endofíticos como fonte de compostos de interesse medicinal – uma breve revisão

Boas

Luiz

Malpass

et al. 2021

Rev. Bras. de Cien., Tec. e Inov.

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Os microrganismos endofíticos, vivem no interior dos tecidos de plantas sem causar nenhum dano aparente ou sinal externo de infecção às mesmas e são pouco estudados. Esses residem, preferencialmente, nos espaços intercelulares mais do que nos espaços intracelulares dos tecidos vegetais e já foram detectados em plantas tropicais, temperadas e de florestas boreais. Os microrganismos endofíticos apresentam importante papel nos ecossistemas influenciando na biodiversidade das comunidades e mediando as interações ecológicas. Além disso, podem atuar na defesa das plantas, diminuir os danos causados por agentes patógenos, insetos, acelerar a emersão de sementes, promover o equilíbrio da planta em condições adversas e aumentar o seu crescimento. Nesse trabalho encontra-se uma breve revisão de artigos científicos que abordam o amplo espectro de atividades biológicas que compostos produzidos por microrganismos endofíticos podem executar, reforçando a importância desses como fonte de compostos de interesse medicinal.

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“…Secondary metabolites were isolated from the fermentation broth of the endophytic fungus Xylaria sp.SYPF 8246, including four new compounds, xylarianins A-D 379-382 (Figure 12), three new natural products, 6-methox-ycarbonyl-2 -methyl-3,5,4 ,6 -tetramethoxy-diphenyl ether 383 (Figure 12), 2-chlor-6-methoxycarbonyl-2 -rnethyl-3,5,4 ,6 -tetramethoxy-diphenyl ether 384 (Figure 12), and 2-chlor-4 -hydroxy-6-methoxy carbonyl-2 -methyl-3,5,6 -trimethoxy-diphenyl ether 385 (Figure 12) [94]. Bysspectin A 386 (Figure 12), a polyketide-derived octaketide dimer with a novel carbon skeleton, and two new precursor derivatives, bysspectins B and C 387-388 (Figure 12), were obtained from an organic extract of the endophytic fungus Byssochlamys spectabilis that had been isolated from a leaf tissue of the traditional Chinese medicinal plant Edgeworthia chrysantha [124]. Fusarithioamide B 389 (Figure 12), a new aminobenzamide derivative with unprecedented carbon skeleton was separated from Fusarium chlamydosporium EtOAc extract isolated from Anvillea garcinii (Burm.f.)…”

Section: Other Types Of Compoundsmentioning

confidence: 99%

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Zheng

Zhang

et al. 2021

IJMS

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Secondary metabolites isolated from plant endophytic fungi have been getting more and more attention. Some secondary metabolites exhibit high biological activities, hence, they have potential to be used for promising lead compounds in drug discovery. In this review, a total of 134 journal articles (from 2017 to 2019) were reviewed and the chemical structures of 449 new metabolites, including polyketides, terpenoids, steroids and so on, were summarized. Besides, various biological activities and structure-activity relationship of some compounds were aslo described.

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Bysspectin A, an unusual octaketide dimer and the precursor derivatives from the endophytic fungus Byssochlamys spectabilis IMM0002 and their biological activities

Cited by 38 publications

References 45 publications

Human carboxylesterases: a comprehensive review

Human carboxylesterases: a comprehensive review

Microrganismos endofíticos como fonte de compostos de interesse medicinal – uma breve revisão

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

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