C-Cyanation with 1-cyanobenzotriazole

Abstract

1-Cyanobenzotriazole is a convenient source of NC + for C-cyanation with in situ-generated sp 3 and sp 2 carbanions providing α-cyano-sulfones, -ketones, -alkanecarboxylate esters, -cyanides, -alkylheterocycles, -diarylmethanes and heterylcarbonitriles in good to high yields (55-78%).

Dehydrosulfurization of Aromatic Thioamides to Nitriles Using Indium(III) Triflate

“…After the reaction mixture was cooled to room temperature, the solvent was washed with aqueous solutions and concentrated by rotary evaporation. Flash column chromatography on silica gel furnished the corresponding nitrile product, which was confirmed by spectroscopy [24]- [28].…”

Ferrocenyl Substituted Pyrazoles, Synthesis via novel route, Spectral Investigations and Their Biological Studies

“…is at 3920 [20][21] ). cyclopentadienyl ring give chemical shift in between 6-8ppm in this value is 6.62 to 6.69 as a multiplet, allylic hydrogen have shift value ranging from 1.6-2.6ppm this peak is identified at 1.83 as a singlet, aromatic cis proton have shift value in region of 6-8ppm which is a doublet at 7.17 to 7.21, N-H peak is identified at 8.77 meanwhile CH-N peak is at 2.38 [22][23]…”

1,2,3-Triazoles

“…Less acidic materials such as Ph-CH 2 -Ph and 2-pyridyl-CH 2 -Me are lithiated with Bu n Li. Nitriles 997 are obtained under mild conditions in average 65% yield ( Scheme 15 ) <2007ARK(iii)5> . Hydrolysis of 1-cyanobenzotriazole 998 with 30% H 2 O 2 provides (benzotriazol-1-yl)carboxylic acid amide( 999 in 79% yield.…”