c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Poveda, Alejandra; Kretz, Robert

doi:10.1016/j.jchemneu.2009.03.006

Cited by 15 publications

(8 citation statements)

References 63 publications

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“…It should be noted that Prichard et al (2002) saw no effect of a 2 hr pulse of light at midnight on cFOS in the DLG of rats. In contrast to these nocturnal rodents, grass rats exhibited a robust response to light, as has been reported in two other diurnal species, tree shrews [123] and Mongolian gerbils [124]. The DLG is an important part of the primary visual system [125–126], but it also plays a role in the masking behavior of mice, as lesions in this area enhance the inhibitory effect of light on activity in these animals [26].…”

Section: Discussionmentioning

confidence: 97%

Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus

Shuboni

Cramm

Yan

et al. 2015

Physiology & Behavior

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Photic cues influence daily patterns of activity via two complementary mechanisms: (1) entraining the internal circadian clock and (2) directly increasing or decreasing activity, a phenomenon referred to as “masking”. The direction of this masking response is dependent on the temporal niche an organism occupies, as nocturnal animals often decrease activity when exposed to light, while the opposite response is more likely to be seen in diurnal animals. Little is known about the neural mechanisms underlying these differences. Here, we examined the masking effects of light on behavior and the activation of several brain regions by that light, in diurnal Arvicanthis niloticus (Nile grass rats) and nocturnal Mus musculus (mice). Each species displayed the expected behavioral response to a 1 h pulse of light presented 2 h after lights-off, with the diurnal grass rats and nocturnal mice increasing and decreasing their activity, respectively. In grass rats light induced an increase in cFOS in all retinorecipient areas examined, which included the suprachiasmatic nucleus (SCN), the ventral subparaventricular zone (vSPZ), intergeniculate leaflet (IGL), lateral habenula (LH), olivary pretectal nucleus (OPT) and the dorsal lateral geniculate (DLG). In mice, light led to an increase in cFOS in one of these regions (SCN), no change in others (vSPZ, IGL and LH) and a decrease in two (OPT and DLG). In addition, light increased cFOS expression in three arousal-related brain regions (the lateral hypothalamus, dorsal raphe, and locus coeruleus) and in one sleep-promoting region (the ventrolateral preoptic area) in grass rats. In mice, light had no effect on cFOS in these four regions. Taken together, these results highlight several brain regions whose responses to light suggest that they may play a role in masking, and that the possibility that they contribute to species-specific patterns of behavioral responses to light should be explored in future.

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Section: Discussionmentioning

confidence: 97%

Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus

Shuboni

Cramm

Yan

et al. 2015

Physiology & Behavior

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“…The tree shrew brain anatomy has only been studied in detail for pathways related to the visual system (see for example Fitzpatrick, 1996; Lyon et al, 2003; Elston et al, 2005; McCoy et al, 2008; Poveda and Kretz, 2009; Chomsung et al, 2010; Day-Brown et al, 2010). Some scarce studies have focused their interest in the general subdivisions of the neocortex (Remple et al, 2007; Wong and Kaas, 2009) as well as in punctual aspects of other brain areas including the striatum (see, e.g., Divac and Passingham, 1980; Oliver, 1982; Lin et al, 1984; Mijnster et al, 1999; Isovich et al, 2000; Keuker et al, 2003; Day-Brown et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Neurochemical Characterization of the Tree Shrew Dorsal Striatum

Rice¹,

Roberts²,

Meléndez-Ferro³

et al. 2011

Front. Neuroanat.

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The striatum is a major component of the basal ganglia and is associated with motor and cognitive functions. Striatal pathologies have been linked to several disorders, including Huntington’s, Tourette’s syndrome, obsessive–compulsive disorders, and schizophrenia. For the study of these striatal pathologies different animal models have been used, including rodents and non-human primates. Rodents lack on morphological complexity (for example, the lack of well defined caudate and putamen nuclei), which makes it difficult to translate data to the human paradigm. Primates, and especially higher primates, are the closest model to humans, but there are ever-increasing restrictions to the use of these animals for research. In our search for a non-primate animal model with a striatum that anatomically (and perhaps functionally) can resemble that of humans, we turned our attention to the tree shrew. Evolutionary genetic studies have provided strong data supporting that the tree shrews (Scadentia) are one of the closest groups to primates, although their brain anatomy has only been studied in detail for specific brain areas. Morphologically, the tree shrew striatum resembles the primate striatum with the presence of an internal capsule separating the caudate and putamen, but little is known about its neurochemical composition. Here we analyzed the expression of calcium-binding proteins, the presence and distribution of the striosome and matrix compartments (by the use of calbindin, tyrosine hydroxylase, and acetylcholinesterase immunohistochemistry), and the GABAergic system by immunohistochemistry against glutamic acid decarboxylase and Golgi impregnation. In summary, our results show that when compared to primates, the tree shrew dorsal striatum presents striking similarities in the distribution of most of the markers studied, while presenting some marked divergences when compared to the rodent striatum.

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“…8 The tree shrew has been thought to be a viable animal model that can serve as an alternative to primates in biomedical research. [8][9][10][11] FV infections in monkeys are highly endemic in Asia. 6,12 However, epidemiological and genotypic data on FVs in Tupaia are unknown.…”

Section: Introductionmentioning

confidence: 99%

Foamy Virus in the Tree Shrew Tupaia Belangeri Is Highly Related to Simian Foamy Virus in Macaca Mulatta

Huang

Wu²,

He³

2013

AIDS Research and Human Retroviruses

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Foamy viruses (FVs) are ancient retrovirus that infect most nonhuman primates and several animals, but are rarely reported in tree shrew Tupaia belangeri. In the present study, foamy virus was detected in tree shrew. Phylogenetic analysis indicated that FVtup shared the highest homology with SFVmac (99.3%) in China. The discovery of FVtup indicated that the tree shrew is a new host of foamy virus. FVtup is highly prevalent in Tupaia in China and there is the possibility of cross-species transmission from nonhuman primate to Tupaia.

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c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Cited by 15 publications

References 63 publications

Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus

Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus

Neurochemical Characterization of the Tree Shrew Dorsal Striatum

Foamy Virus in the Tree Shrew Tupaia Belangeri Is Highly Related to Simian Foamy Virus in Macaca Mulatta

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