C–H functionalization of pyridines

Abstract

Pyridine and its reduced form (piperidines) are the most common nitrogen heterocycles in FDA-approved drugs. Additionally, alkaloids, ligands for transition metals, catalysts, and organic materials with various properties make them...

Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications

“…Notwithstanding the diverse range of alternatives offered by CÀ H bond functionalization, coupled with the problem of regioselectivity, along with directing group introduction and removal, create a major hurdle, which remains a crucial issue in this approach. [17,18,20] Due to the aforementioned reasons, further discussion of this mode will not be pursued. The second methodology Dr. Jiatong Li earned her M.D.…”

A difluoroboron compound with latent fingerprint detection and inkless writing based on aggregation-induced emission enhancement and mechanofluorochromic behavior

“…Pyridine with a six-membered N-heterocyclic structure was usually considered as a good ligand due to strong coordination nature stemming from the pyridine nitrogen. 24 Combining the amide bond linkage moiety of the 2-position in the pyridine skeleton, the compound containing pyridine unit could act as a precursor of difluoroboron compounds. 25 As previously reported, we found that pyridine-based difluoroboron compound with the TPA group at the end of amide bond linkage moiety could be applied in the field of inkless writing.…”

Enantio- and diastereoselective conjugate addition of pyridyl alkyl ketones to enones by Cu(ii)-Lewis acid/Brønsted base catalysis

“…1,2 Thus, the development of effective methods to access pyridine-containing molecules has been a prominent area of research. 3 While one of the most popular approaches involves elaborating the pyridine ring, 4 another valuable strategy includes leveraging this moiety to electronically activate starting materials for stereoselective chemical transformations. 5 Specifically, the CvN moiety within pyridine rings imparts electron-withdrawing properties, augmenting the electrophilicity of adjacent functional groups such as olefins or carbonyls, albeit with a relatively weaker activation compared to isostructural carbonyls.…”