C-mitotic effects of Trichloroethylene (TCE) on bone marrow cells of mice

Sujatha, T V; Hegde, M J

doi:10.1016/s1383-5718(98)00022-9

Cited by 18 publications

(7 citation statements)

References 26 publications

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“…+ Robbiano, Baroni, Carrozzino, Mereto, & Brambilla, ; Sujatha & Hegde, ; Wilmer, Spencer, Ball, & Bus, ; – Wilmer et al, …”

Section: Test Resultsmentioning

confidence: 99%

“…Trichloroethylene has shown a positive in vivo MN test as well as in vitro CMT (Hu et al, 2008;Kligerman et al, 1994). However, CA studies and in vivo CMT have shown negative results (Clay, 2008;Mensing et al, 2002;Sujatha & Hegde, 1998). Sujatha and Hegde (1998) have also reported positive induction of micronuclei in mice bone marrow.…”

Section: Analysis Of Individual and Combinations Of Testsmentioning

confidence: 99%

“…However, CA studies and in vivo CMT have shown negative results (Clay, 2008;Mensing et al, 2002;Sujatha & Hegde, 1998). Sujatha and Hegde (1998) have also reported positive induction of micronuclei in mice bone marrow.…”

Section: Analysis Of Individual and Combinations Of Testsmentioning

confidence: 99%

See 2 more Smart Citations

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Bhagat

2017

J of Applied Toxicology

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“…+ Robbiano, Baroni, Carrozzino, Mereto, & Brambilla, ; Sujatha & Hegde, ; Wilmer, Spencer, Ball, & Bus, ; – Wilmer et al, …”

Section: Test Resultsmentioning

confidence: 99%

Section: Analysis Of Individual and Combinations Of Testsmentioning

confidence: 99%

See 1 more Smart Citation

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Bhagat

2017

J of Applied Toxicology

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“…Several tests are used to assess the (anti)clastogenicity of various compounds in various macro‐ and microorganisms. These include the micronuclei (MN) test, the aberrant anatelophases (AAT) test, the comet assay, the Ames test, the C‐mitotic effects, and the sister‐chromatid exchange induction (Cozzi et al ., 1993; Sujatha & Hegde, 1998; Cotelle et al ., 1999; Kalweit et al ., 1999; Mueller et al ., 1999; Vijayalaxmi & Venu, 1999). In particular, the MN and AAT tests consist of identifying and counting the MN and AAT present in the treated cells.…”

Section: Introductionmentioning

confidence: 99%

Anticlastogenic, antitoxic and sorption effects of humic substances on the mutagen maleic hydrazide tested in leguminous plants

Ferrara

Loffredo

Senesi

2004

European J Soil Science

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The potential anticlastogenic and antitoxic effects of a soil humic acid (HA), a peat HA and a peat fulvic acid (FA) on the mutagen maleic hydrazide (MH) have been investigated in two legume species, Vicia faba and Pisum sativum. Both HAs and FA were tested at two different concentrations, 20 and 200mgl-1, either alone or after 24-hour interaction with 10mgl-1 of MH before addition to the legume seeds. Anticlastogenicity, i.e. an antimutagenic action defined as the capacity for minimizing chromosome breakages, was evaluated by counting both micronuclei (MN) and aberrant anatelophases (AAT) in root-tip cells. Length and dry weight of the seedling primary root were measured to test the antitoxic activity of HA and FA on MH. The possible occurrence and extent of adsorption or desorption of MH onto or fromH A were also investigated. The two species responded differently to the anticlastogenic tests, with V. faba showing a greater number of MN and AAT anomalies than P. sativum. Peat HA and FA exhibited anticlastogenic and antitoxic activities of similar intensity and greater than those of soil HA. The adsorption capacity of both HAs for MH was small, thus suggesting that adsorption is not a major mechanism responsible for the reduction of clastogenicity and antitoxicity of MH by HA

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“…For example, TCE is utilized as an organic solvent for anesthetic and analgesics purposes (1,2), while PCE is mainly used for laundry cleaning purposes (3). Although these artificial organic solvents play an important role when applied in each field, these chemicals are also suspected as carcinogens when released into the environment (4).…”

Section: Introductionmentioning

confidence: 99%

Application of Zerovalent Silicon for the Dechlorination of Chlorinated Hydrocarbons – A Review

Lee

Doong

2013

ACS Symposium Series

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The dechlorination of chlorinated hydrocarbons by zerovalent metals has received much attention. In addition to iron, zerovalent silicon is a strong reductive material which can serve as an alternative for remediation of contaminated sites. However, little is known about the reaction kinetics and mechanism of chlorinated hydrocarbons by zerovalent silicon under anoxic conditions. In this review, parameters controlling the reactivity of silicon in dechlorination were discussed. In addition, the enhanced effects of bimetallic system including Fe/Si and Ni/Si and addition of surfactant on the dechlorination kinetics and mechanisms were also introduced and reviewed. The dechlorination efficiency and rate of chlorinated hydrocarbons by zerovalent silicon increased upon increasing pH from 7.2 to 9.5. The dechlorination followed the pseudo-first-order kinetics and the rate constant (k obs ) for carbon tetrachloride dechlorination increased from 0.5 h -1 at pH 7.2 to 2.11 h -1 at pH 9.5. In addition, tetrachloroethylene (PCE) can be effectively dechlorinated by zerovalent silicon. Addition of Ni 2+ and Fe 2+ significantly enhanced the dechlorination efficiency and rate of PCE as well as changed the distribution of products. However, the roles of Ni 2+ and Fe 0 were different. Addition of Fe 0 to Si could form the buffer solution to maintain the pH at 7.8 when the ratio of Si and Fe is optimized, and subsequently enhanced the dechlorination efficiency and rate of carbon tetrachloride and PCE, while the adsorbed Ni(II) In Interactions of Nanomaterials with Emerging Environmental Contaminants; Doong, R., et al.; ACS Symposium Series; American Chemical Society: Washington, DC, 2013.ions were converted to Ni(0) homogeneously onto the surface of zerovalent silicon and exhibited the synergistic effect on the dechlorination of PCE by Si under anoxic conditions. In addition, the introduction of surfactant can also enhance the dechlorination efficiency, and the dechlorination rate of PCE increased 62 and 106 times higher than silicon alone when CTAB and polyethylene glycol were introduced, respectively. X-ray photoelectron spectroscopy results confirmed that the addition of PEG could inhibit the production of silicon dioxide, resulting in the acceleration of dechlorination rate of PCE by Si. These processes would significantly accelerate the dechlorination rate of chlorinated hydrocarbons under anoxic conditions and would be helpful in facilitating the development of processes that could be useful for the enhanced degradation of co-contaminants for long-term performance. 212Downloaded by UNIV LAVAL on December 1, 2014 |

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C-mitotic effects of Trichloroethylene (TCE) on bone marrow cells of mice

Cited by 18 publications

References 26 publications

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Anticlastogenic, antitoxic and sorption effects of humic substances on the mutagen maleic hydrazide tested in leguminous plants

Application of Zerovalent Silicon for the Dechlorination of Chlorinated Hydrocarbons – A Review

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