c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis.

Schneider, J; Jiménez, E.; Rodríguez, Fausto J.; Tánago, Jaime González del

doi:10.3892/or.5.1.49

Cited by 22 publications

(27 citation statements)

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“…Two recent studies (18,23) demonstrated that the expression of the nm23 gene was decreased in the eutopic and ESCs from women with EM. By contrast, Schneider et al (7) found that the nm23 gene was overexpressed in numerous cases of women with EM. Therefore, the aberrant expression of the nm23 protein may have a role in the development of EM.…”

Section: Discussionmentioning

confidence: 86%

“…The first tumor metastasis-suppressor gene, nm23, may be involved in the development of EM. Thus far, the expression of the nm23 gene in EM has been reported in 4 studies (7,9,18,23). Li and Kong (9) showed that the protein and mRNA expression levels of nm23-H1 in specimens of EM were significantly lower than those in normal endometrium using immunohistochemical surfactant protein and reverse transcription-PCR.…”

Section: Discussionmentioning

confidence: 97%

“…EM is known to be a benign disease, which can be characterized by invasion and atypical growth of endometrial cells at the ectopic sites, and it may occur at distant sites, such as tumor metastasis. A few of the tumor invasion and metastasis-related genes are believed to contribute to the occurrence and continuation of this disease (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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Association between nm23 gene polymorphisms and the risk of endometriosis

Huang

Zhao

et al. 2015

Biomedical Reports

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Abstract. The first tumor metastasis-suppressor gene, nm23, may have an important role in the pathogenesis of endometriosis (EM). The present study aimed to evaluate whether nm23 gene polymorphisms are correlated with the risk of the development of EM in North Chinese women, as a preliminary study. The case-control study was conducted with 379 EM patients and 384 unrelated healthy controls. Genotyping of two polymorphisms within the nm23 gene promoter region (rs16949649 T/C and rs2302254 C/T) were performed using polymerase chain reaction-restriction fragment length polymorphism. The data showed that the rs16949649 and rs2302254 polymorphisms within the nm23 gene were not associated with the risk of developing EM. There were no statistical differences in the distribution of nm23 genotypes between patients with EM and the control group (P= 0.490 and P= 0.440, respectively). For the rs16949649 T/C, compared with the C/T + T/T genotype, the C/C genotype did not increase the risk of EM [odds ratio (OR)= 0.81; 95% confidence interval (CI), 0.57-1.17]. For the rs2302254 C/T, compared with the C/T + C/C genotype, the T/T genotype did not increase the risk of EM (OR=1.46; 95% CI, 0.81-2.64). In conclusion, the findings in the present pilot study suggest that nm23 polymorphisms do not contribute to EM susceptibility. However, more studies in larger populations are required to confirm these results.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Association between nm23 gene polymorphisms and the risk of endometriosis

Huang

Zhao

et al. 2015

Biomedical Reports

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“…40,41 In endometriosis no expression was found in one study. 42 P53. Involvement of the P53 gene is usually shown by immunohistochemical demonstration of overexpression of the p53 protein or by mutation analysis of the gene itself.…”

Section: Specific Genetic Alterations In Endometriosis and Ovarian Camentioning

confidence: 99%

Ovarian endometriosis as a premalignant condition: epidemiological, histological and molecular evidence

Dreyer

2012

Southern African Journal of Gynaecological Oncology

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Endometriosis is a common monoclonal benign proliferative disorder that may give rise to pelvic malignancy. Epithelial ovarian carcinoma is responsible for a large proportion of gynaecological cancer-associated deaths. Early diagnosis is difficult and screening is generally unsuccessful. Knowledge of the risk factors for the development of endometriosis and progression to malignancy may assist in identifying women at risk of developing endometriosis-related neoplasia. The associations between infertility, endometriosis and the development of cancer are reviewed in this article. Proliferative growth, metaplasia, hyperplasia and atypia are identified as proliferative disorders in endometriosis and atypia is considered a premalignant lesion. Several endometriosis-related pelvic malignancies have been described, and these all develop from the multipotent Müllerian cell differentiating into epithelial and/or stromal components. The probable histological type depends on the site of the endometriotic lesion and the population group. Cytogenetic and specific gene alterations that are involved in the carcinogenetic process are described briefly and these may help to predict risk of malignancy or to confirm histological subtype. The importance of endometriosis as a precursor of ovarian and related malignancies was probably seriously underestimated in the past. Advances in molecular testing, histology and our understanding of oncogenesis may empower us to help prevent these devastating diseases.Peer reviewed.

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“…Abnormalities and chromosomal aberrations related to p53 can be associated with the malignant transformation of ovarian endometriosis (Mhawech et al, 2002). Some investigators did not detect altered expression of p53 in endometriosis (Horiuchi et al, 1998;Schneider et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Analysis of p53 codon 72 gene polymorphism in Brazilian patients with endometriosis

Arruda²,

Ct³

et al. 2009

Genet. Mol. Res.

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ABSTRACT. We examined the frequency of p53 codon 72 polymorphism in 38 patients with endometriosis whose diagnosis was confirmed using videolaparoscopy. Half of the women were infertile. There were no significant differences in the genotype (P = 0.0927) or allele frequencies (P = 0.1430) for p53 Arg72Pro polymorphism between the two groups. We found a significant association between the heterozygous and homozygous proline genotypes and intense pain in the patients. Sixty-four percent of the patients were homozygous or heterozygous for proline in patients with degree III or IV endometriosis, but there was no significant difference compared to homozygous arginine genotype (P = 0.6115). We found that the proline allele is associated with substantial complaints (infertility associated with pain), when compared to the homozygous arginine genotype; we also found that the proline allele

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c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis.

Cited by 22 publications

References 0 publications

Association between nm23 gene polymorphisms and the risk of endometriosis

Association between nm23 gene polymorphisms and the risk of endometriosis

Ovarian endometriosis as a premalignant condition: epidemiological, histological and molecular evidence

Analysis of p53 codon 72 gene polymorphism in Brazilian patients with endometriosis

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