2005
DOI: 10.1038/nature03677
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c-Myc-regulated microRNAs modulate E2F1 expression

Abstract: MicroRNAs (miRNAs) are 21-23 nucleotide RNA molecules that regulate the stability or translational efficiency of target messenger RNAs. miRNAs have diverse functions, including the regulation of cellular differentiation, proliferation and apoptosis. Although strict tissue- and developmental-stage-specific expression is critical for appropriate miRNA function, mammalian transcription factors that regulate miRNAs have not yet been identified. The proto-oncogene c-MYC encodes a transcription factor that regulates… Show more

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citations
Cited by 2,618 publications
(2,305 citation statements)
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References 28 publications
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“…This same region, however, is amplified in diffuse large B-cell lymphoma samples He et al, 2005). Thus, as suggested previously (O'Donnell et al, 2005), miRNAs may exert a tumor suppressor or oncogenic effect depending upon the cell type in which they are expressed. In this regard, it is interesting to note that E2F family members can have both cell proliferative and proapoptotic effects in different cellular contexts (Johnson and Degregori, 2006).…”
supporting
confidence: 60%
See 1 more Smart Citation
“…This same region, however, is amplified in diffuse large B-cell lymphoma samples He et al, 2005). Thus, as suggested previously (O'Donnell et al, 2005), miRNAs may exert a tumor suppressor or oncogenic effect depending upon the cell type in which they are expressed. In this regard, it is interesting to note that E2F family members can have both cell proliferative and proapoptotic effects in different cellular contexts (Johnson and Degregori, 2006).…”
supporting
confidence: 60%
“…MiR-34a may have an antiproliferative effect, in part, through targeting the E2F3 transcription factor. Recently, it has been shown that miR-17-5p and miR-20a, which are part of the mir-17 cluster on chromosome 13, act as tumor suppressors by targeting and reducing E2F1 levels (O'Donnell et al, 2005). Similar to miR-34a, the region harboring the miR-17 cluster is hemizygously deleted in some human tumors (Lin et al, 1999).…”
mentioning
confidence: 99%
“…In this study, we show that LMP1 can simultaneously induce several miRs with noted tumor inhibitory capacity and suppress tumor-promoting miRs (He et al, 2005;O'Donnell et al, 2005;Chang et al, 2008). Furthermore, we identified that LMP1, through its CTAR1 and CTAR2 domains, activates miR-29b expression to regulate TCL1 oncogene.…”
Section: Discussionmentioning
confidence: 70%
“…For miR‐17~92, various research groups have found that these miRNAs are regulated by oestrogen stimuli in vivo and in vitro 25, 33, 34, 35. The molecule basis of the phenomenon has been described above for the co‐regulation effects of activated ESα (oestrogen‐binding ESα) and transcription factor c‐myc 25, 36, 37. Based on our results, we added new evidence that the expression of miR‐17~92 was modulated by oestrogen and then showed sex disparity in the liver.…”
Section: Discussionmentioning
confidence: 99%