C–O Coupling/[4+2] Cycloaddition Tandem Reactions via Oxidative Dearomatization of BINOLs: Access to Bridged Polycyclic Compounds

Abstract

Intramolecular C−H activation/C−O coupling, dearomatization, and [4+2] cycloaddition of BINOL units have been well developed in a one-pot approach with maleimide derivatives as the dienophiles. This tandem catalytic system generates a variety of functionalized bridged polycyclic products in a step-economical manner, which greatly enriches the modification methods and strategies for the BINOL skeletons.

Cascade 1,3-Dipolar Cycloaddition and Lactamization for Diastereoselective Synthesis of Pyrrolidinedione-Fused Tetrahydropyrroloisoindolones

“…Chemicals and solvents, unless otherwise noted, were purchased from Energy Chemical or BidePharm and used without further purification. N -Substituted maleimides 2c – 2n were prepared according to the literature procedure . The X-ray data was collected on a Bruker D8 VENTURE instrument.…”