C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight

Verhaeghe, Johan; Bree, Rieta Van; Herck, Erik Van; Laureys, Jozef; Bouillon, Roger; Assche, F.A. Van

doi:10.1016/0002-9378(93)90137-8

Cited by 219 publications

(133 citation statements)

References 21 publications

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“…Serum IGF-I levels are strongly associated with both fetal and postnatal growth (5). This together with the data from Vaessen et al (1) make variation at the IGF-I gene an ideal candidate for influencing growth and diabetes risk.…”

mentioning

confidence: 81%

A Putative Functional Polymorphism in the IGF-I Gene

et al. 2002

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IGF-I has a critical role in growth and metabolism. A microsatellite polymorphism 1 kb upstream to the IGF-I gene has recently been associated with several adult phenotypes. In a large Dutch cohort, the absence of the commonest allele (Z) was associated with reduced serum IGF-I levels, reduced height, and an increased risk of type 2 diabetes and myocardial infarction. This result has not been replicated, and the role of this polymorphism in these traits in U.K. subjects is not known. We sought further evidence for the involvement of this variant in type 2 diabetes using a case-control study and IGF-I and diabetes-related traits in a population cohort of 640 U.K. individuals aged 25 years. Absence of the common allele was not associated with type 2 diabetes (odds ratio 0.70, 95% CI 0.47-1.04 for X/X versus Z/Z genotype, 2 test for trend across genotypes, P ‫؍‬ 0.018). In the population cohort, the common allele (Z) was associated with decreased IGF-I levels (P ‫؍‬ 0.01), contrary to the Dutch study, but not with adult height (P ‫؍‬ 0.23), glucose tolerance (P ‫؍‬ 0.84), oral glucose tolerance test-derived values of ␤-cell function (P ‫؍‬ 0.90), or insulin resistance (P ‫؍‬ 0.66). There was no association with measures of fetal growth, including birth weight (P ‫؍‬ 0.17). Our results do not support the previous associations and suggest that the promoter microsatellite is unlikely to be functionally important.

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confidence: 81%

A Putative Functional Polymorphism in the IGF-I Gene

et al. 2002

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“…Studies that measured 17-hydroxyprogesterone, a metabolite of progesterone, have found significantly higher blood levels in males than in female newborns (51), particularly among the full-term deliveries (52). Whereas IGF-I plays an important role in fetal growth and development and has a strong positive association with birth weight of newborns (53,54), gender difference in maternal and fetal levels of IGF-I has not been consistently observed (55,56). However, in a study that adjusted for maternal factors and ponderal index, higher levels of IGF-I were found in cord blood of female offspring (56).…”

Section: Offspring Gender and Maternal Risk Of Ovarian Cancer Cancer mentioning

confidence: 95%

Gender of Offspring and Maternal Risk of Invasive Epithelial Ovarian Cancer

Baik¹,

Lambe²,

Liu³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Gender of a fetus is associated with maternal hormonal milieu and may therefore modify maternal risk of ovarian cancer following a birth. We evaluated the relation between gender of offspring and maternal risk of epithelial ovarian cancer in a large casecontrol study nested within a nationwide cohort. Cohort members were identified in the Swedish Fertility Register. Cases of invasive epithelial ovarian cancer were identified in the Swedish National Cancer Register from 1961 to 2001. Five controls were matched by age to each case. A total of 7,407 cases and 37,658 controls with only singleton births were included in the analysis. We fit logistic regression models to study the association between gender of offspring and ovarian cancer risk, controlling for covariates. Maternal risk of ovarian cancer was reduced with increasing numbers of male offspring and increased with number of female offspring. Compared with women who gave birth to only girls, multivariate odds ratios (95% confidence interval) of invasive epithelial ovarian cancer were 0.92 (0.87-0.98) for those who gave birth to one boy, 0.87 (0.80-0.94) for two boys, and 0.82 (0.73-0.94) for three or more boys (P value test for trend < 0.001). There was a positive but nonsignificant association with number of girls. Similar results were observed when restricting the analysis to women born before 1935. Our findings suggest that hormonal and physiologic conditions in pregnancy with male, but not with female, offspring are associated with a lowered maternal risk of invasive epithelial ovarian cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2314 -20)

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“…Most studies addressing the associations of the IGF system with birth size have focused on differences between small for gestational age neonates resulting from a variety of etiologies and appropriate for gestational age neonates; however, the greatest breast cancer risks are observed for women born heavy. In studies conducted in normal pregnancies with a range of birth weights, the positive association between birth size and cord IGF-I concentrations is well established (89)(90)(91)(92)(93)(94)(95)(96)(97)(98). IGFBP-3 has also been positively associated with birth size in most studies (75,95,96,99), whereas IGFBP-1 may be inversely associated (90,95).…”

Section: Prominent Hypotheses To Explain Prenatal Risk Factorsmentioning

confidence: 99%

“…In studies conducted in normal pregnancies with a range of birth weights, the positive association between birth size and cord IGF-I concentrations is well established (89)(90)(91)(92)(93)(94)(95)(96)(97)(98). IGFBP-3 has also been positively associated with birth size in most studies (75,95,96,99), whereas IGFBP-1 may be inversely associated (90,95). Associations of IGF-2 with birth size are unclear (92,93,99), as is the role of IGFBP-2, the main IGFBP in the fetal circulation (99).…”

Section: Prominent Hypotheses To Explain Prenatal Risk Factorsmentioning

confidence: 99%

Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary

Troisi

Potischman

Hoover

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Prenatal factors have been hypothesized to influence subsequent breast cancer development. Directly evaluating the associations of in utero exposures with risk, however, presents several methodologic and theoretical challenges, including the long induction period between exposure and disease and the lack of certainty regarding the critical timing of exposure. Indirect evaluation of these associations has been achieved by use of proxies such as gestational and neonatal characteristics. Evidence suggests that preeclampsia is associated with a reduced breast cancer risk, whereas high birth weight and dizygotic twinning seem associated with an increased risk. Asians born in Asia have substantially lower breast cancer risks than women born in the West. Although data thus far are few, what exists is not consistent with a unifying hypothesis for a particular biological exposure (such as estrogens or androgens) during pregnancy as mediating the observed associations between pregnancy factors and breast cancer risk. This suggests that additional studies of prenatal factors should seek to broaden the range of hormones, growth, and other endocrine factors that are evaluated in utero. Once candidate biomarkers are identified, assessing them with respect to breast cancer and with intermediate end points in carcinogenesis should be a priority. In addition, investigations should explore the possibility that in utero exposures may not act directly on the breast, but may alter other physiologic pathways such as hormone metabolism that have their effect on risk later in life. (Cancer Epidemiol Biomarkers Prev 2007;16(9):1700 -12)

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C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight

Cited by 219 publications

References 21 publications

A Putative Functional Polymorphism in the IGF-I Gene

A Putative Functional Polymorphism in the IGF-I Gene

Gender of Offspring and Maternal Risk of Invasive Epithelial Ovarian Cancer

Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary

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