2011
DOI: 10.4187/respcare.01007
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C-Reactive Protein Alone or Combined With Cardiac Troponin T for Risk Stratification of Respiratory Intensive Care Unit Patients

Abstract: BACKGROUND: Mortality is high among patients admitted to intensive care units (ICUs). Several prognostic markers have been described in such patients, but the literature contains no data comparing C-reactive protein (CRP) and cardiac troponin T (cTn-T), nor of a combination of CRP and cTn-T in the same patient group in the ICU. METHODS: This was a retrospective electronic data review of patients who presented to the emergency department for respiratory reasons between December 2007 and December 2009 and in who… Show more

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Cited by 7 publications
(7 citation statements)
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“…C-reactive protein has been found to differentiate patients with pneumonia from those with endotracheal infections (71), to aid in the diagnosis of appendicitis (82), or to differentiate bacterial and viral infections (251). Studies of critically ill patients showed that elevated plasma concentrations of CRP were correlated with an increased risk of organ failure and/or death (131,156,199). However, in another prospective study of postoperative sepsis, where the courses of procalcitonin (PCT), interleukin-6 (IL-6), and CRP were evaluated as a percent decrease from the baseline in order to predict survival at day 28 after the onset of sepsis, PCT and IL-6 levels significantly decreased in survivors from days 1 to 14, whereas CRP levels did not (278).…”
Section: Acute-phase Protein Biomarkersmentioning
confidence: 99%
“…C-reactive protein has been found to differentiate patients with pneumonia from those with endotracheal infections (71), to aid in the diagnosis of appendicitis (82), or to differentiate bacterial and viral infections (251). Studies of critically ill patients showed that elevated plasma concentrations of CRP were correlated with an increased risk of organ failure and/or death (131,156,199). However, in another prospective study of postoperative sepsis, where the courses of procalcitonin (PCT), interleukin-6 (IL-6), and CRP were evaluated as a percent decrease from the baseline in order to predict survival at day 28 after the onset of sepsis, PCT and IL-6 levels significantly decreased in survivors from days 1 to 14, whereas CRP levels did not (278).…”
Section: Acute-phase Protein Biomarkersmentioning
confidence: 99%
“…Elevated cardiac troponins also occur in patients with non‐ischemic myocardial injury who have congestive heart failure, myocarditis, sepsis or trauma and in patients with chronic renal insufficiency [Ammann et al, ; Lazzeri et al, ]. An elevated troponin level is similarly correlated with mortality and morbidity in patients admitted to the intensive care unit [Ammann et al, ; Ozsu et al, ]. Lim et al [] reported that cTn‐T levels in patients without acute coronary syndrome admitted to intensive care were elevated by 12–85%.…”
Section: Discussionmentioning
confidence: 99%
“…The troponin level in these patients is thought to increase secondary to myocardial damage arising as the result of underlying diseases, hypoxia, acidosis, and therapeutic approaches [Ammann et al, ; King et al, ]. Elevated troponin levels have been reported to be correlated with morbidity and mortality in some studies [Ammann et al, ; Ozsu et al, ].…”
Section: Introductionmentioning
confidence: 99%
“…The ROC curve for DNB to determine success of visceral blocks is similar to that of other commonly used tests for relatively common issues. For example, the AUC for CRP used to stratify ICU admissions is 0.691 (CI: 0.608 to 0.775) 23 . Another example is the use of Lp(a), having the largest AUC, as the best marker for unstable angina 24 .…”
Section: Discussionmentioning
confidence: 99%