C-reactive protein and copeptin: prognostic predictors in chronic obstructive pulmonary disease exacerbations

Antonescu-Turcu, Andreea; Tomic, Rade

doi:10.1097/mcp.0b013e3283218603

Cited by 31 publications

(17 citation statements)

References 36 publications

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“…It has been established in previous studies that various inflammatory markers like C-reactive protein (CRP), fibrinogen and leucocyte count increase in stable patients of COPD and that this increase is associated with the negative results of the disease [7][8][9][10]. Moreover, it has been described that elevated CRP levels can be used in the diagnosis of acute exacerbation and to approximate the prognosis of the disease [11,12].…”

Section: Introductionmentioning

confidence: 99%

The Importance of Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease

İn

Kuluöztürk

Öner

et al. 2016

Turk Toraks Dergisi

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OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by airflow limitation and systemic inflammation. Recently, neutrophil-to-lymphocyte ratio (NLR) has gathered increasing interest in the detection of inflammation in inflammatory diseases. This study aimed to investigate the role of NLR in COPD for identifying the detection of inflammation and recognition of acute exacerbation. MATERIAL AND METHODS:The laboratory results of 103 COPD patients were included into the study, of which 47 patients were in acute exacerbation and 56 patients were at stable period, and there were 40 gender and age-matched healthy controls. Complete blood count (CBC), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were evaluated. NLR was calculated from CBC. RESULTS:NLR values of patients with COPD (both acutely exacerbated and stable) were found significantly higher than those of the controls (p< 0.001, p< 0.05; respectively). In all patients with COPD, NLR values positively correlated with serum CRP (r= 0.641, p< 0.001) and ESR (r= 0.276, p= 0.005) levels and negatively correlated with forced vital capacity (r= -0.20, p= 0.043) and forced expiratory volume in the 1 st second (r= -0.288, p= 0.003). For an NLR cutoff of 3.34, sensitivity for detecting exacerbation of COPD was 78.7% and specificity was 73.2% (AUC 0.863, p< 0.001). CONCLUSION:Our results suggest that NLR may be considered as a reliable and simple indicator in the determination of increased inflammation in patients with COPD. Furthermore, NLR could be useful for the early detection of possible acute exacerbations in patients with COPD.

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Section: Introductionmentioning

confidence: 99%

The Importance of Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease

İn

Kuluöztürk

Öner

et al. 2016

Turk Toraks Dergisi

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“…So, nowadays, being able to measure the copeptin level simply and quickly encourages most clinicians to investigate the vasopressin system in various clinical conditions. For instance, copeptin was shown to be increased during acute exacerbation of chronic obstructive pulmonary disease [25]. In another study, Morgenthaler et al [26] studied copeptin in hemorrhagic and septic shock patients.…”

Section: Discussionmentioning

confidence: 99%

Copeptin Level and Copeptin Response to Percutaneous Balloon Mitral Valvuloplasty in Mitral Stenosis

Günebakmaz

Çelik²,

İnanç³

et al. 2011

Cardiology

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We aimed to investigate copeptin levels in mitral stenosis (MS) patients and the behavior of copeptin after hemodynamic improvement achieved by percutaneous balloon mitral valvuloplasty (PBMV). The study involved 29 consecutive symptomatic patients with moderate to severe rheumatic MS who underwent PBMV. Twenty-eight age- and gender-matched healthy volunteers composed the control group. Blood samples for copeptin were obtained immediately before and 24 h after PBMV, centrifuged, then stored at -70°C until assayed. The copeptin level of the patient group was statistically different from that of the control group (61.8 ± 34.4 and 36.8 ± 15.2 pg/ml, respectively; p = 0.001). PBMV resulted in a significant increase in mitral valve area and a significant decrease in transmitral gradient as well as systolic pulmonary artery pressure. While hemodynamic relief was obtained, we detected a statistically significant decline in copeptin levels 24 h after PBMV compared to the baseline levels (from 61.8 ± 34.4 to 44.1 ± 18.2 pg/ml; p = 0.004).

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“…In the last two decades, increased serum CRP levels have been extensively evaluated as a marker of systemic infl ammation in COPD exacerbations (19,20). Current studies have reported that CRP alone is neither sensitive nor specifi c in predicting clinical severity or outcome of COPD exacerbations and speculate that utilizing combinations of biomarkers may prove more useful (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations

Nikolakopoulou

Hillas

Perrea

et al. 2013

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Available online on: 15.01.2018@http://ijrdpl.co m http://dx. ABSTRACT: Background: Chronic Obstructive pulmonary disease a systemic inflammatory disease, characterized by airway inflammation and progressive airflow limitation is an increasing cause of morbidity and mortality worldwide including India. C-reactive protein (CRP) is an acute phase reactant secreted by the liver in response to infection, inflammation or tissue damage. Objectives: The aim of this study was to investigate serum levels of CRP in North Indian population and to study its correlation with disease severity. Methods: This case control study was conducted on 145 healthy controls and 145 stable COPD patients at a tertiary care hospital in north India. CRP levels were measured in serum by ELISA kits. Results: The present study showed that mean serum CRP levels was significantly higher in COPD group as compared to control group (p<0.0001)] and the levels increased with the increasing severity of the disease. Conclusion: Our study confirms that C-reactive protein levels were higher in stable COPD patients as compared to controls and their levels increased with the increasing severity of the disease. Measuring CRP levels in combination with other biochemical markers can be helpful in monitoring disease outcome and management of disease.

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C-reactive protein and copeptin: prognostic predictors in chronic obstructive pulmonary disease exacerbations

Abstract: Further studies are needed to determine the role of CRP and copeptin as biomarkers that aid in diagnosis and clinical outcome in acute exacerbation of COPD.

Cited by 31 publications

References 36 publications

The Importance of Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease

The Importance of Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease

Copeptin Level and Copeptin Response to Percutaneous Balloon Mitral Valvuloplasty in Mitral Stenosis

Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations

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