C–reactive Protein and Early Mortality in Acute Ischemic Stroke

Dewan, Khus Raj; Rana, Pvs

doi:10.3126/kumj.v9i4.6339

Cited by 17 publications

(25 citation statements)

References 25 publications

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“…Data demonstrated that elevated CRP in plasma could predict not only future vascular events in healthy individuals, but also an increased risk of fatal or nonfatal cerebrovascular events in ischemic stroke patients 12. Elevated CRP levels at admission are significantly associated with early neurologic deterioration 13, poorer functional outcome, both short- and long-term mortality after stroke 14-15 and predict a larger infarct size 16-17. Our study provides further evidence that elevated CRP could be served as a biomarker for the diagnosis of non-cardioembolic stroke subtype, especially within 1 day of stroke onset.…”

Section: Discussionmentioning

confidence: 99%

Differences of Circulating Inflammatory Markers between Large- and Small Vessel Disease in Patients with Acute Ischemic Stroke

Zeng¹,

He²,

Liu³

et al. 2013

Int. J. Med. Sci.

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Background: The difference of inflammatory response between the pathogenesis of cerebral large- and small vessel disease after stroke remains unclear. In present study, we aim to determine the association of circulating inflammatory markers with different stroke subtype.Methods: 99 patients with non-cardioembolic stroke were divided into large artery atherosclerosis (LAA) and small-artery occlusion (SAO) according to TOAST classification. A panel of plasma inflammatory markers including leukocyte, lymphocyte, CRP, fibrinogen, D-dimer, CD40L, IFN-γ, IL-1α, IL-1β, IL-6, IL-8, IL-17 and TNF-α were measured within 72 hours following cerebral ischemia. The relation of their levels in plasma with stroke subtype was further studied. All statistical data analysis was performed by SPSS 17.0 software.Results: We found that only CRP were closely associated with stroke subtype (p<0.05). Compared to SAO subgroup, the plasma levels of CRP was higher in LAA subgroup (p<0.05). The predictive efficiency of CRP more than 3.2 for LAA was 85.7% sensitivity. The influencing factor of CRP includes IL-6, lymphocyte, fibrinogen and D-dimer.Conclusion: LAA had a stronger activation of inflammation than SAO in the pathogenesis, which was associated with the changes of CRP.

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Section: Discussionmentioning

confidence: 99%

Differences of Circulating Inflammatory Markers between Large- and Small Vessel Disease in Patients with Acute Ischemic Stroke

Zeng¹,

He²,

Liu³

et al. 2013

Int. J. Med. Sci.

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“…Most of the studies evaluated for the co-morbidities showed predominance of hypertension and diabetes mellitus as major contributors to the mortality in stroke patients with hyponatremia. [21][22][23][24][25][26] More studies are needed however to quantify the effects of hyponatremia on mortality in acute stroke patients, and to find the mortality benefit that we can get by correcting this factor. Similar studies from other centers in the country are also needed see the overall effect of this in our population from different parts of the country.…”

Section: Discussionmentioning

confidence: 99%

Impact of hyponatremia on outcome of acute ischemic stroke in a tertiary care hospital.

Kidwai

Ara

Rasheed

et al. 2019

TPMJ

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Objectives: To determine the frequency and impact of hyponatermia on outcome in patients of acute ischemic stroke admitted to a Tertiary Care Hospital, Karachi. Study Design: Prospective, cross-sectional, observational study. Setting: Department of Medicine, Abbasi Shaheed Hospital, Karachi. Period: January 2015 to May 2018. Material and Methods: A total of 110 patients of both gender presented with acute ischemic stroke and hyponatermia (2 consecutive serum sodium levels (< 135 mEq/L). Diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and cerebral salt wasting (CSW) was based on predefined criteria. Mortality was considered in terms of modified Rankin Scale with score of 6 within four weeks of admission. Data was analyzed by using SPSS Version 20. Result: Out of 110 acute ischemic stroke patients, 66 (60%) were male and 44 (40%) were female. The mean age was 61.45 ± 11.8 years. Mean serum sodium level was 128.4 ± 6.07. Older ages are associated with high mortality rate of 20%. Moderate (29%) and severe (11%) hyponatremia was associated with 21% and 33% mortality respectively. Overall mortality in patients with hyponatremia was 14.5%. Conclusion: Mortality rates are higher in acute ischemic stroke patients presented with moderate to severe hyponatremia.

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“…Another scholar compared the correlation between hs-CRP levels and infarcted volume and found a positive relationship between the 2. The majority of clinical scholars use hs-CRP as an indicator for assessing stroke progress, prognosis, and recurrence [ 22 – 24 ]. A number of scholars have studied guinea pig brain specimens and blood-brain barrier in vitro cell culture models, which show that CRP induces blood-brain barrier damage, resulting in cerebral edema through a signal transduction pathway [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Urinary Kallidinogenase on Transforming Growth Factor-β1 and High-Sensitivity C-Reactive Protein Expression in Rat Focal Cerebral Ischemic Injury

Dong

Niu

et al. 2016

Med Sci Monit

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BackgroundIn this study we investigated the effect of urinary kallidinogenase (UK) on transforming growth factor beta 1 (TGF-β1) expression in brain tissue. We also explored the neuroprotective mechanism of UK against ischemic injury by measuring serum high-sensitivity C-reactive protein (hs-CRP) level changes after rat cerebral ischemic injury.Material/MethodsThe rat middle cerebral artery ischemia/reperfusion model was established using the suture method. Sprague-Dawley rats were randomly divided into 3 groups: treatment, Gegen control, and blank control. Each group was subsequently divided into 5 subgroups according to time (6, 12, 24, 48, and 72 h). Rats in the treatment group were administered UK as treatment. TGF-β1 expression was observed at each time point using SABC and immunohistochemical staining methods to estimate cerebral infarct volume percentage. Serum hs-CRP levels were also measured.ResultsTGF-β1 protein expression in ischemic brain tissues of the treatment group significantly increased at each time point (P<0.01) compared with both control groups. Treatment group serum hs-CRP levels significantly decreased at each time point (P<0.05) compared with both control groups.ConclusionsUK exerts a neuroprotective effect by upregulating TGF-β1 expression and inhibiting excessive inflammatory responses.

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C–reactive Protein and Early Mortality in Acute Ischemic Stroke

Abstract: Background

Cited by 17 publications

References 25 publications

Differences of Circulating Inflammatory Markers between Large- and Small Vessel Disease in Patients with Acute Ischemic Stroke

Differences of Circulating Inflammatory Markers between Large- and Small Vessel Disease in Patients with Acute Ischemic Stroke

Impact of hyponatremia on outcome of acute ischemic stroke in a tertiary care hospital.

Effect of Urinary Kallidinogenase on Transforming Growth Factor-β1 and High-Sensitivity C-Reactive Protein Expression in Rat Focal Cerebral Ischemic Injury

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