C-reactive Protein and its Relationship with Lipid Profile in Suicidal and Non Suicidal Adults with Major Depression

Al-Amarei, Hassam M.; Rasheed, Suaad Mohammed H.; Eidan, Ali J.

doi:10.5958/0976-5506.2019.01632.2

Cited by 10 publications

(8 citation statements)

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“…Twenty‐one studies included subjects with different disorders, one study included only subjects diagnosed with BD, 56 ten studies investigated patients with MDDs, 9 , 22 , 23 , 24 , 25 , 39 , 40 , 57 , 58 , 59 and four studies included people affected by mood disorders. 11 , 41 , 44 , 60 Moreover, one study was focused on first‐episode psychosis, 61 and five studies evaluated patients with mixed disorders.…”

Section: Resultsmentioning

confidence: 99%

“…For instance, Karlovic and colleagues showed that IL6 was associated with SI within patients with depression with melancholic (32 patients) and atypical (23 patients) features, yet no difference was found in the concentration of CRP 39 . In addition, CRP concentrations are increased also in suicide attempters with depressive disorder, 25,58 but no differences in the levels of serum hs‐CRP among suicide attempters and among non‐suicide attempters with MDD were found 40 . Moreover, such association appears to be accounted for the presence of physical disease among patients receiving care in a medical setting 57 …”

Section: Discussionmentioning

confidence: 99%

“…More in detail, a possible pathway implicating immune‐inflammatory processes is through the release of cytokines and their consequences, which have neurotoxic effects, lead to a breakdown of the blood‐brain barrier, thereby allowing activated immune cells and their products to influence brain functions. 25 …”

Section: Introductionmentioning

confidence: 99%

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Increased C‐reactive protein concentration and suicidal behavior in people with psychiatric disorders: A systematic review and meta‐analysis

Miola

Porto

Tadmor

et al. 2021

Acta Psychiatr Scand

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Objective Suicide is a leading cause of death worldwide. Identifying factors associated with suicidality (suicidal ideation [SI]/suicidal behavior) could increase our understanding of the pathophysiological underpinnings of suicide and improve its prevention. Methods We conducted a systematic review (PubMed/PsycInfo/Cochrane databases, up to September 2020) and random‐effect meta‐analysis including observational studies comparing peripheral C‐reactive protein (CRP) levels in suicidal versus non‐suicidal patients affected by any psychiatric disorder and healthy controls (HC). Primary outcome was the CRP standardized mean difference (SMD) between patients with high suicidality versus those with absent or low suicidality. Secondary outcomes were SMD of CRP levels between those with suicide attempt versus no suicide attempt, as well as between those with (high) versus low or absent SI. Quality of included studies was measured with Newcastle‐Ottawa scale. Results Out of initial 550 references, 21 observational studies involving 7682 subjects (7445 with mood disorders or first‐episode psychosis, 237 HC) were included. A significant association of CRP levels with suicidality (SMD 0.688, 95% CI 0.476–0.9, p < 0.001) emerged. CRP levels were higher in individuals with high SI (SMD 1.145, 95% CI 0.273–2.018, p = 0.010) and in those with suicide attempt (SMD 0.549, 95%CI 0.363–0.735, p < 0.001) than non‐suicidal individuals (either patients or HC). Main analyses were confirmed in sensitivity analysis (removing HC), and after adjusting for publication bias. The cross‐sectional design of included studies, and the high heterogeneity of diagnosis and treatment limit the generalizability of these results. Median quality of included studies was high. Conclusion CRP is associated with higher suicidality in patients with mental disorders. Large cohort studies longitudinally monitoring CRP levels are needed to explore its longitudinal association with suicidality.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Increased C‐reactive protein concentration and suicidal behavior in people with psychiatric disorders: A systematic review and meta‐analysis

Miola

Porto

Tadmor

et al. 2021

Acta Psychiatr Scand

View full text Add to dashboard Cite

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“…The results of the study showed that CRP was significantly higher in suicide attempters than in depressed patients who did not attempt suicide and in healthy controls. TG levels were significantly higher in depressed patients compared to healthy controls 31 .…”

Section: Discussionmentioning

confidence: 73%

Association between lipid ratio and depression: a cross-sectional study

Han

2022

Sci Rep

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Depression is associated with total cholesterol, low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol levels in the blood. However, evidence is limited on the relationship between depression and lipid ratios. Therefore, this study aimed to investigate the correlation between depression and different lipid ratios. This study was conducted using data from the Korea National Health and Nutrition Examination Survey. A total of 11,648 adult men and women aged ≥ 19 years, without missing data, were included in this study. Depression was diagnosed using the Patient Health Questionnaire-9. The associations between depression and total cholesterol/high-density lipoprotein cholesterol, low-density cholesterol/high-density lipoprotein cholesterol, and triglyceride/high-density lipoprotein cholesterol ratio were analyzed. A complex sample logistic regression test was used for the analysis of the odds ratios of depression. Among men, the total cholesterol/high-density lipoprotein cholesterol and low-density cholesterol/high-density lipoprotein cholesterol ratios were not associated with depression. Additionally, an increase in triglyceride/high-density lipoprotein cholesterol ratio by 1 was associated with a 1.041-fold higher probability of depression in men. Among women, the three lipid ratios were not associated with depression. Triglyceride/high-density lipoprotein cholesterol ratio is associated with depression among men. Future studies should cross-validate, explore the biological mechanism, and identify the clinical implication of this correlation.

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“…Accumulating evidence suggests that inflammation plays an important role in the pathogenesis of SB. Inflammation is associated with cytokine release, leading to neurotoxic effects and breakdown of the blood-brain barrier (BBB), which allows activated immune cells and their products to affect brain function [ 7 ]. Therefore, inflammatory cytokines may be key modulators of inflammation.…”

Section: Inflammatory Markersmentioning

confidence: 99%

Peripheral Markers of Suicidal Behavior: Current Findings and Clinical Implications

Kang

Kim

et al. 2023

Clin Psychopharmacol Neurosci

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Biomarkers of suicidal behavior (SB), particularly peripheral biomarkers, may aid in the development of preventive and intervention strategies. The peripheral biomarkers of SB should be easily accessible, cost-effective, and minimally invasive. To identify peripheral biomarkers of SB, we summarized the current knowledge related to SB biomarkers with a focus on suicidal outcomes (suicidal ideation [SI], suicide risk [SR], suicide attempt [SA], and suicide death [SD]), measured site (center or periphery), and study design (cross-sectional or longitudinal). We also evaluated the central findings to validate the findings of peripheral biomarkers of SB. We found reduced peripheral interleukin (IL)-2 levels in individuals with a recent SA, higher cerebrospinal fluid (CSF) IL-6 levels in patients with a current SR and future SD, higher CSF tumor necrosis factor-α levels for current and future SRs, higher high-sensitivity C-reactive protein levels and lower peripheral total cholesterol levels for recent SAs, lower peripheral 5-HT levels for present SR, and a lower folate level for future SR and SA within 1 year. Previous studies have shown inconsistent associations of low peripheral leptin levels with SR and recent SA; therefore, further study is required. Given the multiple determinants of SB and weak associations with single biological markers, combinations of potential biological markers rather than single markers may improve the screening, diagnosis, and prediction of SB.

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C-reactive Protein and its Relationship with Lipid Profile in Suicidal and Non Suicidal Adults with Major Depression

Cited by 10 publications

References 0 publications

Increased C‐reactive protein concentration and suicidal behavior in people with psychiatric disorders: A systematic review and meta‐analysis

Increased C‐reactive protein concentration and suicidal behavior in people with psychiatric disorders: A systematic review and meta‐analysis

Association between lipid ratio and depression: a cross-sectional study

Peripheral Markers of Suicidal Behavior: Current Findings and Clinical Implications

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