C-reactive protein and subclinical cardiovascular disease among African−Americans

Sung, Jung Hye; Lee, Jae Eun; Samdarshi, Tandaw E.; Nagarajarao, Harsha S.; Taylor, Jason K; Agrawal, Khushboo; Taylor, Herman A.; Fox, Ervin R.

doi:10.2459/jcm.0b013e32836411d6

Cited by 14 publications

(5 citation statements)

References 30 publications

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“…High CRP levels are reported a potential indicator of subclinical atherosclerosis . Hashimoto et al performed carotid artery ultrasonography and measured Hs‐CRP levels in patients aged 40‐79 years with cardiovascular risk factors and found that Hs‐CRP is a marker of atherosclerotic activity in the early stages of the disease .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of subclinical atherosclerosis in Turkish patients with acne vulgaris receiving systemic isotretinoin

Karapınar

Polat

Buğdaycı

2020

Dermatologic Therapy

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Studies conducted on isotretinoin have shown that it may indirectly lead to atherosclerosis. The objective of this study was to determine the effect of systemic isotretinoin on subclinical atherosclerosis. The present study included 63 patients with acne vulgaris who had used isotretinoin for 6 months. Glucose, insulin, and homeostatic model assessment of insulin resistance levels; body mass index; waist circumference; blood pressure; lipid profile; and lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1), high‐sensitivity C‐reactive protein, and oxidized low‐density lipoprotein (Ox‐LDL) levels were compared in the patients at the initiation and discontinuation of the treatment. At the discontinuation of the treatment, LOX‐1 and Ox‐LDL levels showed a significant increase (P < .001 and P = .040, respectively). Differences in waist circumference were positively correlated with an increase in LOX‐1 levels (r = .274; P = .030). Isotretinoin causes an increase in the levels of subclinical atherosclerosis markers. Although the present study sample size was small, we believe that caution should be exercised considering the risk of atherosclerosis during isotretinoin use in men with high waist circumference and cardiovascular risk factors; further studies are warranted in this regard.

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Section: Discussionmentioning

confidence: 99%

Evaluation of subclinical atherosclerosis in Turkish patients with acne vulgaris receiving systemic isotretinoin

Karapınar

Polat

Buğdaycı

2020

Dermatologic Therapy

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“…Smoking triggers chronic immunologic responses that upregulate biomarkers associated with inflammation and multi-organ disease, including plasma C-reactive protein (CRP) [ 1 – 3 ]. This, coupled with the relatively low smoking cessation rate (~3 %) among U.S. adults underscores the importance of daily smokers engaging in health-enhancing behaviors such as physical activity and healthy eating [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Combined association of physical activity and diet with C-reactive protein among smokers

Loprinzi

Walker

2015

J Diabetes Metab Disord

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BackgroundIn the general population, both physical activity and dietary behavior are independently associated with less systemic inflammation, with this relationship less examined among smokers. To our knowledge, no study has examined the combined association of both physical activity and dietary behavior on systemic inflammation among daily smokers, which was the purpose of this study.MethodsData from the 2003–2006 NHANES were employed. 810 adult smokers provided C-reactive protein data (CRP; a marker of inflammation), and sufficient physical activity (accelerometry) and dietary data (healthy eating index).ResultsThe fully adjusted model showed that participants meeting physical activity guidelines and eating a healthy diet (β = −0.34, p = 0.03) had lower CRP levels when compared to those not engaging in these health behaviors, but only having one health behavior was not a significant predictor of CRP (β = −0.19, p = 0.14).ConclusionsSmokers engaging in regular physical activity while consuming a healthy diet demonstrate lower CRP levels than their counterparts. When taken together, these behaviors may mitigate inflammation associated with various chronic diseases, which is of particular importance as very few smokers successfully quit smoking.

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“…The DCC provided three online and five onsite workshops, developed/distributed more than 250 copies of the booklet and posted instructions on the RTRN website to facilitate the data utility. Five related manuscript proposals, eleven presentations, seven published papers [ 46 , 47 , 48 , 49 , 50 , 51 , 52 ] and two R01 and two small (R03 and R21) grant proposals were supported.…”

Section: Discussionmentioning

confidence: 99%

User-Friendly Data-Sharing Practices for Fostering Collaboration within a Research Network: Roles of a Vanguard Center for a Community-Based Study

Lee

Sung

Barnett

et al. 2015

IJERPH

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Although various attempts have been made to build collaborative cultures for data sharing, their effectiveness is still questionable. The Jackson Heart Study (JHS) Vanguard Center (JHSVC) at the NIH-funded Research Centers in Minority Institutions (RCMI) Translational Research Network (RTRN) Data Coordinating Center (DCC) may be a new concept in that the data are being shared with a research network where a plethora of scientists/researchers are working together to achieve their common goal. This study describes the current practices to share the JHS data through the mechanism of JHSVC. The JHS is the largest single-site cohort study to prospectively investigate the determinants of cardiovascular disease among African-Americans. It has adopted a formal screened access method through a formalized JHSVC mechanism, in which only a qualified scientist(s) can access the data. The role of the DCC was to help RTRN researchers explore hypothesis-driven ideas to enhance the output and impact of JHS data through customized services, such as feasibility tests, data querying, manuscript proposal development and data analyses for publication. DCC has implemented these various programs to facilitate data utility. A total of 300 investigators attended workshops and/or received training booklets. DCC provided two online and five onsite workshops and developed/distributed more than 250 copies of the booklet to help potential data users understand the structure of and access to the data. Information on data use was also provided through the RTRN website. The DCC efforts led to the production of five active manuscript proposals, seven completed publications, 11 presentations and four NIH grant proposals. These outcomes resulted from activities during the first four years; over the last couple of years, there were few new requests. Our study suggested that DCC-customized services enhanced the accessibility of JHS data and their utility by RTRN researchers and helped to achieve the principal goal of JHSVC of scientific productivity. In order to achieve long-term success, the following, but not limited to these, should be addressed in the current data sharing practices: preparation of new promotional strategies in response to changes in technology and users’ needs, collaboration with the Network statisticians, harmonization of the JHS data with the other local-based heart datasets to meet the needs of the potential users from the broader geographical areas, adoption of the RTRN comprehensive data-sharing policy to broaden the variety of research topics and implementation of an ongoing monitoring program to evaluate its success.

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C-reactive protein and subclinical cardiovascular disease among African−Americans

Cited by 14 publications

References 30 publications

Evaluation of subclinical atherosclerosis in Turkish patients with acne vulgaris receiving systemic isotretinoin

Evaluation of subclinical atherosclerosis in Turkish patients with acne vulgaris receiving systemic isotretinoin

Combined association of physical activity and diet with C-reactive protein among smokers

User-Friendly Data-Sharing Practices for Fostering Collaboration within a Research Network: Roles of a Vanguard Center for a Community-Based Study

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