C-Reactive Protein as a Prognostic Indicator in Dogs with Acute Abdomen Syndrome

Abstract

Abstract. The objective of the present study was to measure serum C-reactive protein (CRP) concentrations in 32 dogs with acute abdomen syndrome at presentation and after 48-72 hr. Data were evaluated to determine if there was an association between CRP concentration and outcome, and if CRP concentration correlated with the white blood cell (WBC) count at both time points. An immunoturbidimetric assay for human CRP, previously validated for use in dogs, was used for serum CRP analysis. Increased serum CRP concentrations were found in 21 dogs at presentation. Fifteen of these dogs had declining serum CRP concentrations by 48-72 hr, but 3 of the 15 dogs were later euthanized. Serum CRP concentrations increased by 48-72 hr in 4 dogs. Of the 32 dogs, 4 were dead or were euthanized prior to the 48-72 hr time point. No significant difference between initial CRP concentration and outcome was found (P 5 0.054). Initial and 48-72 hr CRP values taken together were significantly different between outcome groups (P , 0.001). Serum CRP concentrations that were elevated at both time points were associated with a poor prognosis. No correlation was found between CRP concentrations and WBC counts at presentation (P 5 0.83); however, a significant correlation was noted at 48-72 hr (P 5 0.03). Evaluation of sequential CRP concentrations in dogs with acute abdomen syndrome may be helpful in assessing clinical response to treatment and predicting outcome. Also, serum CRP may be better in detecting tissue injury and/or inflammation at presentation than WBC counts in select cases.

Acute Phase Proteins in Animals

“…Acute abdomen syndrome was reported to result in up to 200-fold increases in CRP. 99 Nonsurvivors were observed to have significantly higher levels of CRP than survivors.…”

Manifestação de síndrome paraneoplásica em um cão com hemangiossarcoma cutâneo: relato de caso

“…Com relação a PCR, trabalhos descritos por Calazans et al (2009), Planellas et al (2009), Tecles et al (2009), Crossley et al (2010, Galezowski et al (2010), Mukorera et al (2011) e Battisti et al (2013 demostraram elevação dos níveis séricos desta, em animais com neoplasias malignas como neoplasia mamária, linfoma, câncer pancreático e carcinoma de células escamosas. Dados estes, que não se correlacionaram com o presente relato, onde não foi verificado o aumento sérico desta proteína, sugerindo-se que as variações séricas da PCR em animais com neoplasias podem ocorrer em função da cronicidade da inflamação tecidual, dimensão do tumor e presença de metástases (Tecles et al, 2009;Crossley et al, 2010).…”

Proteínas de fase aguda em cadelas com neoplasia mamária

“…No presente estudo, o leucograma infl amatório associado ao aumento expressivo da PCR e da Hp e redução na albumina foram observados nas pacientes com neoplasia ulcerada. Esse resultado indica que o aumento das PFA em cadelas com neoplasia mamária maligna ulcerada ocorre pela maior infl amação tecidual (CÉRON et al, 2005;GRIEBSCH et al, 2009;GALEZOWSKI,et al, 2010). A infl amação peritumoral leva à ativação de macrófagos e à liberação de citocinas, que são importantes na ativação da resposta de fase aguda, com consequentes alterações das PFA (BALKWILLet al, 2005;ROXBURGH & McMILLAN, 2010).…”

“…Alteração individual de PFA em cães com neoplasia foi demonstrada em pesquisas recentes, apesar do não estabelecimento de um padrão dessas alterações (PLANELLAS et al, 2009;TECLES et al, 2009;CROSSLEY et al, 2010;GALEZOWSKI et al, 2010;MUKORERA et al, 2011). O aumento da PCR foi demonstrado em cães com neoplasia mamária e correlacionado com pior prognóstico (CROSSLEY et al, 2010;MUKORERA et al, 2011).…”

“…Estudos recentes demonstraram variações nas PFA em cães portadores de tumores mamários, pancreáticos, carcinoma de células escamosas e linfoma (CALAZANS et al, 2009;GALEZOWSKI et al, 2010;MUKORERA et al, 2011), e em seres humanos no câncer de próstata e mama (STARK et al, 2009). Nas neoplasias mamárias, as variações dos valores séricos das PFA podem ocorrer em função da infl amação tecidual crônica, do tamanho do tumor primário e da presença de metástases (TECLES et al, 2009;CROSSLEY et al, 2010).…”