C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes

Yang, Jin; Wang, Junhong; Zhu, Shushu; Chen, Xiangjian; Wu, Hengfang; Yang, Di; Zhang, Jinan

doi:10.1007/s11010-007-9683-3

Cited by 28 publications

(19 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21 A similar result has been presented by Yang and colleagues. 22 However, it is notable that the mentioned researches have been performed in an in-vitro model while our data validates the previous works through an in-vivo study. To date, many studies have demonstrated the antiapoptosis effect of ghrelin in different cell lines and by special mechanisms.…”

Section: Discussionsupporting

confidence: 87%

Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats

et al. 2015

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 87%

Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats

et al. 2015

View full text Add to dashboard Cite

“…46,51 Previous studies indicated that CRP might promote apoptosis in endothelial progenitor cells 52 and cardiac myocytes. 53 We showed that TUNEL-positive cells were increased in CRP/DM compared with Wt/DM. Furthermore, the ratio of Bax/Bcl-2, which is known to be an important marker of cardiomyocyte apoptosis, 53,54 was also increased in CRP/DM compared with Wt/DM.…”

Section: Discussionmentioning

confidence: 68%

Overexpression of Human C-Reactive Protein Exacerbates Left Ventricular Remodeling in Diabetic Cardiomyopathy

Mano

Anzai

Kaneko

et al. 2011

Circ J

View full text Add to dashboard Cite

“…Although CRP may be involved in the apoptotic process of normal myocytes and endothelial cells under stressful conditions [33,34], a recent study suggested that CRP binds to specific receptors and protects malignant myeloma cells from apoptosis [35]. Of interest, continuously accumulating clinical evidence suggests that high CRP levels before surgery are linked with poor postoperative outcome in several malignancies including renal [36], ovarian [37] and colon cancer [38].…”

Section: Radiotherapy Intent Crp Levels (Mg/dl)mentioning

confidence: 99%

Serum C-reactive Protein (CRP) Levels in Cancer Patients are Linked with Tumor Burden and are Reduced by Anti-hypertensive Medication

et al. 2009

View full text Add to dashboard Cite

High levels of CRP relate with advanced disease and poor prognosis of cancer patients. CRP serum levels were measured in 684 cancer patients who had undergone complete surgery or inoperable patients. Patients with inoperable tumors had significantly higher CRP levels (1.21 +/- 2.2 vs. 0.40 +/- 0.4 mg/dL; p < 0.0001). No association with gender, diabetes, autoimmune disease, thyroid disease or allergy was noted. Significantly higher CRP levels were noted in operated patients with hypertension (0.55 +/- 0.5 vs. 0.35 +/- 0.4; p = 0.001), coronary disease (0.73 +/- 0.8 vs. 0.39 +/- 0.4; p = 0.01) and obesity (0.51 +/- 0.5 vs. 0.37 +/- 0.4; p = 0.04). On the contrary, analysis in the group of inoperable patients showed that hypertensive patients had significantly lower CRP levels (0.64 +/- 1.0 vs. 1.36 +/- 2.4; p = 0.008). Although the tumor itself is the main factor defining increased CRP levels in cancer patients, hypertension, coronary disease and obesity are also linked with high CRP levels. Anti-hypertensive drugs appear as potent suppressors of the tumor-induced CRP production.

show abstract

C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes

Cited by 28 publications

References 44 publications

Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats

Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats

Overexpression of Human C-Reactive Protein Exacerbates Left Ventricular Remodeling in Diabetic Cardiomyopathy

Serum C-reactive Protein (CRP) Levels in Cancer Patients are Linked with Tumor Burden and are Reduced by Anti-hypertensive Medication

Contact Info

Product

Resources

About