C‐Reactive Protein Concentration in Dogs with Chronic Valvular Disease

Abstract

The purpose of the study reported here was to determine whether dogs with chronic valvular disease have increased plasma Creactive protein concentration, compared with that in clinically normal dogs. Blood was collected from 47 dogs with physical and echocardiographic evidence of chronic valvular disease and from 20 healthy controls. C-reactive protein concentration was determined with a commercial canine C-reactive protein enzyme immunoassay. Compared with controls, dogs with chronic valvular disease had higher plasma concentration of C-reactive protein (median 2.17 mg/mL [range, 0.86-33.8 mg/mL]) versus 1.43 mg/mL [range, 0.84-4.99 mg/mL]; P , .001). C-reactive protein concentration was not related to the presence of congestive heart failure or murmur grade. The results of this study suggest that increased concentration of C-reactive protein is found in dogs with chronic valvular disease.

Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach

“…Elevated CRP levels have been reported in dogs after surgical trauma [14], during infections including leishmaniasis [15], ehrlichiosis [16], babesiosis [5], leptospirosis [17], bordetellosis [18], parvovirus infection [17] and pyometra [19], and with noninfectious conditions including neoplasia [20], autoimmune disorders [20], acute pancreatitis [21], inflammatory bowel disease [22] and cardiac valvular disease [23]. Several researchers have explored the acute phase response and specifically CRP in canine babesiosis [5].…”

Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty

“…The reference range for serum CRP concentration in apparently healthy dogs for this assay has been reported to be between 1 and 5 mg/mL. 22 Balloon valvuloplasty was performed via the right jugular vein as previously described. 24 Balloon catheters used for the procedures were selected based on the recommended balloon-toannulus ratio (BAR) of 1.2e1.5.…”

“…20,21 An increase in serum CRP concentrations has been documented in dogs with acquired valvular heart disease but serum CRP concentrations have not been reported in dogs with congenital heart disease. 22 The effect of severe PS and balloon valvuloplasty on markers of myocardial damage and inflammation in dogs is unknown. Therefore, the purpose of this study was to report serum cTnI and CRP concentrations in dogs with severe PS before and after balloon valvuloplasty.…”

C-reactive protein as an indicator of inflammatory responses to experimentally induced cystitis in dogs

“…Therefore, mildly increased CRP concentrations may be observed in cases of chronic bacterial cystitis that are commonly encountered in veterinary clinics. Mildly increased CRP levels are associated with other chronic diseases in dogs such as chronic valvular disease [median 2.17 mg/L (range: 0.86~3.8 mg/L)] and inflammatory bowel disease (15.33 ± 4.85 mg/L) as well [14,27]. Compared to the levels observed before treatment, CRP concentrations in Group 4 decreased rapidly and significantly starting on day 3 (the time at which antibiotic treatment was initiated) until the end of the experiment.…”

“…Since UTI is the most common cause of serious occult bacterial infections in young children seen in emergency departments [29], researchers have attempted to investigate the use of CRP for diagnosing UTIs in children compared to radiologic, laboratory, and clinical findings such as dimercaptosuccinic acid, renal scintigraphy, WBC counts, erythrocyte sedimentation rates, and duration of fever [10,12]. In veterinary medicine, numerous authors have investigated the usefulness of canine serum CRP measurement as a tool for diagnosing and monitoring various diseases including immune-mediated hemolytic anemia [17], pyometra [8], chronic valvular disease [27], acute gastric mucosal injury [24], idiopathic polyarthritis [22], and surgical trauma [32]. However, alterations in CRP concentration have not been evaluated in cases of canine bacterial cystitis.…”