C-Reactive Protein (CRP) as a Marker in Peripheral Vascular Disease

Abdellaoui, Adel; Al‐Khaffaf, Haytham

doi:10.1016/j.ejvs.2006.10.040

Cited by 39 publications

(23 citation statements)

References 29 publications

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“…This finding is also consistent with studies evaluating specifically PAD in both general population and hemodialysis patients. 30-32 The lower serum creatinine levels in the low ABI group suggest that some degree of malnutrition was present in these patients, a comorbidity correlated with inflammation.…”

Section: Discussionmentioning

confidence: 98%

Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study

Miguel¹,

Matos²,

Lugon³

2017

Arquivos Brasileiros De Cardiologia

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BackgroundAbnormal ankle-brachial index (ABI) has been found to be a strong predictor of mortality in some hemodialysis populations in studies with relatively short periods of follow-up, lower than 2 years.ObjectiveThis study aimed to assess the predictive value of abnormal ABI as a risk factor for death among patients on maintenance hemodialysis after a 5-year follow-up.MethodsA total of 478 patients on hemodialysis for at least 12 months were included in the study. ABI measurement was performed using a mercury column sphygmomanometer and portable Doppler. Patients were divided into 3 groups according to ABI (low: <0.9; normal: 0.9 to 1.3; and high: >1.3) and followed for a 60-month period.ResultsThe prevalence rates of low, normal and high ABI were 26.8%, 64.6% and 8.6%, respectively. The 5-year survival rate was lower in the groups with low ABI (44.1%, P<0.0001) and high ABI (60.8%, P= 0.025) than in the group with normal ABI (71.7%). Cox regression was used to evaluate the association between ABI and mortality, adjusting for potential confounders. Using normal ABI as reference, a low, but not a high ABI was found to be an independent risk factor for all-cause mortality (HR2.57; 95% CI, 1.84-3.57 and HR 1.62; 95% CI, 0.93-2.83, respectively).Conclusionslong-term survival rates of patients with either low or high ABI were lower than the one from those with normal ABI. However, after adjustment for potential confounders, only low ABI persisted as an independent risk factor for all-cause mortality among hemodialysis patients.

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Section: Discussionmentioning

confidence: 98%

Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study

Miguel¹,

Matos²,

Lugon³

2017

Arquivos Brasileiros De Cardiologia

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“…However, studies that tried to associate clinical severity in adult [18, 21, 41] and children [42] patients with respiratory diseases and serum levels of cytokines had controversial results. In the present study, the cytokines, TNF, IL-1β, IL-6, IL-8, IL-12p70, IFN-γ, IL-17A, IL-10 and IL-5, were detected in the serum of children with pneumonia and severe pneumonia at hospital admission, and IL-6 was the only cytokine associated with disease severity.…”

Section: Discussionmentioning

confidence: 99%

“…Blood count and serum levels of CRP are low-cost laboratory tests, accessible in health services in countries with limited resources and their results help the differentiation between viral or bacterial respiratory infection [3, 14, 17]. High levels of CRP are caused bythe activity of circulating tumor necrosis factor (TNF) in the liver as a response to the infectious process; therefore, CRP is considered a nonspecific marker [18]. …”

Section: Introductionmentioning

confidence: 99%

The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia

et al. 2016

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BackgroundTo identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between serum cytokine profile of children with different pneumonia severity.MethodsIn 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests, Pearson correlation and ROC curve for cut-off definition of cytokines.ResultsAt admission, IL-6 serum levels were high in mild or severe pneumonia, and was associated to vomiting (P = 0.019) in both groups; and also to dyspnea (P = 0.012) and white blood cell count (P = 0.045) in patients with severe pneumonia. IL-10 levels were also high in patients with pneumonia and were associated to lymphocytosis (P = 0.025). The ROC curve of the IL-6:IL-10 serum levels ratio discriminated severe pneumonia cases at admission, and persistence of infection in the third day of antibiotic therapy, with positive predictive values of 93% and 89%, respectively.ConclusionsThe balance between IL-6 and IL-10 serum levels showed to be a more discriminative marker for severity definition and evaluation of recovery in patients with pneumonia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-016-0324-z) contains supplementary material, which is available to authorized users.

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“…Five participants (four girls, one boy) with CRP values above 10.0 mg . L -1 were determined outliers and excluded from further analysis [37]. CRP, HOMA, body mass, BMI, WC, fat mass, trunk fat mass, aFM and %fat were positively skewed and were normalized by logarithmic transformations.…”

Section: Methodsmentioning

confidence: 99%

Fatness but Not Fitness Relative to the Fat-Free Mass Is Related to C-Reactive Protein in 18 Year-Old Adolescents

et al. 2015

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IntroductionThe interaction between fatness, fitness, and C-reactive protein (CRP) in adolescents is not well characterized but may be important to prevent low grade inflammation. The purpose of this study was to assess the relationship between adiposity, different expressions of fitness, and CRP in late adolescence using direct measures of fitness and fatness.MethodsAnthropometric measurements were taken on 245 eighteen-year-old participants (116 girls). Fasting CRP, glucose, and insulin were measured and homeostatic model assessment (HOMA) calculated. Body composition was estimated via dual energy X-ray absorptiometry. Fitness was assessed with maximal oxygen uptake (VO2max) during a treadmill test and also expressed relative to the fat-free mass (VO2maxFFM).ResultsPrevalence of overweight/obesity based on body mass index (BMI) was 20.7% and 25.6% among girls and boys, respectively (p = 0.407), but 42.5% and 58.1% when based on body fat percentage (%fat, p = 0.015). Higher proportion of boys (81.3%) than girls (54.5%) were highly fit (p<0.001), but the percentage of girls with high levels of CRP was greater (12.1% vs 6.2%, p = 0.028). Adiposity, indicated with BMI, waist circumference, fat mass, android fat mass (aFM), or %fat, was positively associated with CRP independent of VO2max (r = 0.13-0.18, p<0.05) and VO2maxFFM (r = 0.24-0.32, p<0.001). VO2max, was negatively associated with CRP independent only of BMI and waist circumference (r = -0.21, p = 0.001), but not %fat, fat mass or aFM (r = -0.08 to -0.12, p>0.05). VO2maxFFM was unrelated to CRP with (r = -0.07 to -0.11, p>0.05) or without (r = -0.10, p = 0.142) adjustment for adiposity. Additional adjustment for HOMA did not change any of the relationships, although the coefficients were attenuated.ConclusionsFatness has a greater association with CRP than fitness in late adolescence. However, VO2maxFFM, which is truly independent of adiposity, is unrelated to CRP, indicating that the effects of fitness might be mediated via the fatness component embedded in fitness expressed relative to body mass.

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C-Reactive Protein (CRP) as a Marker in Peripheral Vascular Disease

Abstract: CRP appears to be a strong predictor and marker of severity of PVD and also may predict the risk of restenosis after angioplasty.

Cited by 39 publications

References 29 publications

Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study

Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study

The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia

Fatness but Not Fitness Relative to the Fat-Free Mass Is Related to C-Reactive Protein in 18 Year-Old Adolescents

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