2021
DOI: 10.1111/codi.15963
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C‐reactive protein (CRP) trajectory as a predictor of anastomotic leakage after rectal cancer resection: A multicentre cohort study

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Cited by 13 publications
(4 citation statements)
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“…Additionally, we found that variational index also contributed greatly in the model (Figure 4 ), like minimum albumin level, maximum count of white blood cell and maximum ascending amount of CRP etc. Several studies have learnt the importance of trajectory of clinical variables in prognostic research 33 , 34 , although some of the research also suggested that variational index alone lacked predictive value to rule out postoperative AL 35 . In this study, we combined variational index with other perioperative variables and examined by machine learning methods, and eventually found the clinical contribution and importance of the changes in these variables.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, we found that variational index also contributed greatly in the model (Figure 4 ), like minimum albumin level, maximum count of white blood cell and maximum ascending amount of CRP etc. Several studies have learnt the importance of trajectory of clinical variables in prognostic research 33 , 34 , although some of the research also suggested that variational index alone lacked predictive value to rule out postoperative AL 35 . In this study, we combined variational index with other perioperative variables and examined by machine learning methods, and eventually found the clinical contribution and importance of the changes in these variables.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, it can exert a positive influence on survival rates and recurrence, thereby contributing to improved patient outcomes [23]. A plethora of biomarkers have been extensively investigated to prognosticate the incidence of AL subsequent to esophagectomy [24][25][26][27][28][29][30], including C-reactive protein (CRP) or procalcitonin (PCT) [31][32][33][34][35]. Plasma cytokine levels have shown promise as potential predictors of AL [36][37][38][39] and reportedly have greater diagnostic abilities for AL, compared with CRP or PCT [37].…”
Section: Introductionmentioning
confidence: 99%
“…However, the best response to elevated CRP values is not well defined. Some physicians remeasure CRP levels in the following days [15,20], while some centres perform computed tomography in patients with CRP levels >15 mg/dL on POD 2 or 3 [12].…”
Section: Introductionmentioning
confidence: 99%