C-reactive protein expression in a rodent model of chronic cerebral hypoperfusion

Juma, Wafa M.; Lira, Arman; Marzuk, Ali; Marzuk, Zaynab; Hakim, Antoine M.; Thompson, C. S.

doi:10.1016/j.brainres.2011.07.047

Cited by 33 publications

(20 citation statements)

References 44 publications

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“…More recent studies suggest a potential link between high serum levels of CRP with the presence and severity of AD [21] and PD [22,23,24], suggesting a role of CRP in the pathogenesis of neurodegenerative diseases. A recent study indicates that pro-inflammatory cytokines induce CRP expression in primary microglia [25]. To the best of our knowledge, the current study is the first demonstration of CRP expression by astrocytes and the first to demonstrate that resveratrol inhibits LPS-induction of CRP production in these cells.…”

Section: Discussionmentioning

confidence: 58%

Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases

Wight

Tull

Deel

et al. 2012

Biochemical and Biophysical Research Communications

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Inflammatory molecules have been implicated in the pathogenesis of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis. Resveratrol is an anti-fungal compound found in the skins of red grapes and other fruits and nuts. We examined the ability of resveratrol to inhibit lipopolysaccharide (LPS)-induced production of inflammatory molecules from primary mouse astrocytes. Resveratrol inhibited LPS-induced production of nitric oxide (NO); the cytokines tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), and IL-6; and the chemokine monocyte chemotactic protein-1 (MCP-1), which play critical roles in innate immunity, by astrocytes. Resveratrol also suppressed astrocyte production of IL-12p40 and IL-23, which are known to alter the phenotype of T cells involved in adaptive immunity. Finally resveratrol inhibited astrocyte production of C-reactive protein (CRP), which plays a role in a variety of chronic inflammatory disorders. Collectively, these studies suggest that resveratrol may be an effective therapeutic agent in neurodegenerative diseases initiated or maintained by inflammatory processes.

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Section: Discussionmentioning

confidence: 58%

Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases

Wight

Tull

Deel

et al. 2012

Biochemical and Biophysical Research Communications

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“…epithelial cells, lymphocytes) ( Ramage et al, 2004 , Marc et al, 2004 ). However, local production in extrahepatic synthesis of CRP may be a process of localized inflammation and a marker for local cellular damage ( Juma et al, 2011 ). Tissue studies have shown that extensive diffuse alveolar damage is the most notably histological feature in severe fatal cases with avian influenza infection.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein Mediating Immunopathological Lesions: A Potential Treatment Option for Severe Influenza A Diseases

et al. 2017

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Severe influenza diseases with high mortality have been frequently reported, especially in those patients infected with avian influenza A (H5N1, H7N9 or H10N8) or during a pandemic. Respiratory distress, which is attributed to alveolar damage associated with immunopathological lesions, is the most common cause of death. There is a wealth of information on pathogenesis or treatment options. In this study, we showed that high levels of C-reactive protein (CRP) were induced and correlated with complement activation in patients infected with severe influenza A (H5N1, H7N9 or H10N8), and higher levels were induced in fatal patients than in survivors. CRP treatment enhanced the phagocytosis of monocytes THP-1 to H5N1 virus as well as the expression of proinflammatory cytokines or apoptosis-associated genes in THP-1 cells or pneumocytes A-549 respectively. CRP may link to proinflammatory mediators contributing to activation of complement and boosting inflammatory response in severe influenza infections. Compound 1,6-bis(phosphocholine)-hexane improved the severity and mortality of mice infected with lethal influenza virus significantly. These observations showed that CRP is involved in deterioration of severe influenza diseases, and indicated a substantial candidate molecule for immunotherapy of severe influenza diseases.

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“…The mechanisms of these responses have not been fully elucidated, but several factors may play a role. Cerebral hypoperfusion is associated with white matter inflammation and oxidative stress in rodent models (Dong et al, 2011; Huang et al, 2010; Ihara et al, 2001; Juma et al, 2011; Masumura et al, 2001; Reimer et al, 2011; Yoshizaki et al, 2008), indicating that hypoxia-ischemia is sufficient to trigger these responses. Vascular risk factors for VCI, such as hypertension, insulin resistance and diabetes, lead to vascular oxidative stress and inflammation, both in animal models and in humans (Cohen and Tong, 2010; Iadecola and Davisson, 2008; Yates et al, 2012), which, in turn, impair the factors regulating the cerebral circulation (Faraci, 2011).…”

Section: Pathogenic Mechanisms Responsible For White Matter Injurymentioning

confidence: 99%

The Pathobiology of Vascular Dementia

Iadecola

2013

Neuron

1,464

1,399

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Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to full-blown dementia, attributable to cerebrovascular causes. Often coexisting with Alzheimer’s disease, mixed vascular and neurodegenerative dementia has emerged as the leading cause of age-related cognitive impairment. Central to the disease mechanism is the crucial role that cerebral blood vessels play in brain health, not only for the delivery of oxygen and nutrients, but also for the trophic signaling that links inextricably the well being of neurons and glia to that of cerebrovascular cells. This review will examine how vascular damage disrupts these vital homeostatic interactions, focusing on the hemispheric white matter, a region at heightened risk for vascular damage, and on the interplay between vascular factors and Alzheimer’s disease. Finally, preventative and therapeutic prospects will be examined, highlighting the importance of midlife vascular risk factor control in the prevention of late-life dementia.

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C-reactive protein expression in a rodent model of chronic cerebral hypoperfusion

Cited by 33 publications

References 44 publications

Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases

Resveratrol effects on astrocyte function: Relevance to neurodegenerative diseases

C-Reactive Protein Mediating Immunopathological Lesions: A Potential Treatment Option for Severe Influenza A Diseases

The Pathobiology of Vascular Dementia

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