C‐reactive protein in children with obstructive sleep apnea and the effects of treatment

Abstract

Summary. Objective To evaluate C-reactive protein (CRP) concentration in children with OSA and to determine the effects of treatment for OSA on its serum concentration. Methods Consecutive children with habitual snoring and symptoms suggestive of OSA were recruited. They completed a sleep apnea symptom questionnaire, underwent physical examination and an overnight polysomnography (PSG). Fasting serum CRP and lipid profile were taken after overnight PSG. OSA was diagnosed if obstructive apnea index (OAI) > 1. Results One hundred forty-one children with a median (IQR) age of 10.8 (8.5-12.8) years were recruited. There were 96 boys and the commonest presenting symptoms were nocturnal mouth breathing, prone sleeping position and poor attention at school. Forty-five children were found to have OSA and those with moderate disease (OAI > 5) had significantly higher CRP levels compared to their non-OSA counterparts

Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome

“…Four studies (including 2 from the same center) showed no relationship between CRP and OSAS, 71-74 whereas 4 studies (2 from the same center) did show a relationship. 46,[75][76][77] Part of the discrepancy between studies may be attributable to the varying proportions of obese subjects (because obesity is associated with high CRP levels) and varied age of subjects and definitions of OSAS in the different studies. Some studies controlled for obesity and degree of OSAS, whereas others did not.…”

Re: The Association Between Hay Fever and Stroke in a Cohort of Middle Aged and Elderly Adults

“…CRP dropped after tonsillo-adenoidectomy in children. 7 Other factors that might be involved in atherosclerosis, like fibrinogen level and p-selectin (marker of platelet activation), were shown to be higher in those with OSA.…”

Obstructive sleep apnea and cardiovascular risk in children

“…Повышение уровня С-реактивного белка на фоне обструктивного апноэ сна выявлено как у взрослых [48], так и у де-тей [49]. Снижение его уровня отмечено при эффек-тивном лечении апноэ сна у детей [50]. Повышение показателя С-реактивного белка и иных медиато-ров воспаления на фоне обструктивного апноэ сна у детей, как полагают, во многом модифицируется влиянием генетических факторов [51].…”