C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death

Hertog, Heleen M. den; Rossum, J.A. van; Worp, H. Bart van der; Gemert, H. Maarten A. van; Jonge, Robert de; Koudstaal, Peter J.; Dippel, Diederik W.J.

doi:10.1007/s00415-009-5228-x

Cited by 125 publications

(92 citation statements)

References 30 publications

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“…Studies have shown that CRP was strongly associated with the prognostic outcome after AIS (1,19,24,25). Ormstad et al (1) found that CRP played an important role in the progression of cerebral tissue injury.…”

Section: Discussionmentioning

confidence: 99%

Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

Sezer¹,

Uçar²,

Ulusoy³

et al. 2014

Turk J Med Sci

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A nonlinear process between co-propagating signal and control pulses has been proposed and demonstrated numerically, based on semiconductor optical amplifiers (SOA). Results show that a Gaussian signal pulse with picosecond duration can be simultaneously amplified and compressed in a SOA by utilizing a co-propagating high-intensity control pulse. To obtain high quality signal pulse with high peak power level and short pulse width, the center carrier wavelengths of two pulses should locate in the gain region of the SOA. The initial delay time between both pulses should be tuned suitably before entering the SOA.

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Section: Discussionmentioning

confidence: 99%

Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

Sezer¹,

Uçar²,

Ulusoy³

et al. 2014

Turk J Med Sci

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“…Age was categorized as <50, 50-59, 60-69, 70-79 and ≥80 years. The level of CRP was categorized as <7mg/L and ≥7mg/L (Due to the skewed distribution of CRP, we chose a somewhat arbitrary cut off point for CRP: values below 7mg/L were considered normal) 11 . National Institutes of Health Stroke Scale values were dichotomized at 8, which was considered as relatively severe illness 12 .…”

Section: Baseline Variablesmentioning

confidence: 99%

Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

Luo

Wang²,

Li³

et al. 2012

Can. J. Neurol. Sci.

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Elevated serum C reactive protein (CRP) concentrations have been found in acute ischemic stroke (AIS) patients [1][2][3][4][5][6][7][8][9][10] , which reflects a systemic inflammatory response following stroke 1 . It is possible that the increased CRP has a close relationship with the extent of cerebral tissue injury 2 . Previously studies paid more attention to its prognostic role of outcome, however, study on the correlation between elevated CRP levels and stroke severity, especially with the stroke subtype is limited.The aim of this retrospective study was to investigate elevated CRP in relation to stroke severity, and analyze its different distribution in stroke subtypes. Here, three subtypes of ischemic stroke were studied, taking into account etiology and clinical and image classification. METHODS Study designData for this study were obtained at Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ABSTRACT: Objective: The aim of this retrospective study was to investigate if elevated C reactive protein (CRP) was related to the stroke severity, and to analyze its different distribution in stroke subtypes. Methods: 316 patients with acute ischemic stroke (AIS) were enrolled and had CRP determinations; they were dichotomized as<7 or≥7mg/L according to the previous report. 128 patients with transient ischemic attack who also had CRP measurements were selected as controls. A possible level-risk relationship between elevated CRP and NIHSS, which considered relatively severe illness as a value≥8, was studied within the AIS group. Results: CRP was elevated in 21% of the AIS compared to 4% in the control group (p = 0.000). Within the AIS group, patients with CRP levels ≥7mg/L had a significantly increased risk of severe stroke (OR 3.33, 95% CI 1.84-6.00, p =0.00). In subtype stroke, the highest rate of elevated CRP and NIHSS were in those with cardioembolic stroke (CE) using TOAST classification, total anterior circulation infarction (TACI) of OCSP classification and large volume infarction (LVI) of Adams classification; the odds ratio(OR) between elevated CRP and NIHSS was 6.14 (95% CI 1.43-26.44) in CE, 1.714 (95% CI 1.30-2.26) in TACI, 2.32 (95% CI 1.08-4.99) in LVI, and the p value were all below 0.05. Conclusion: Elevated CRP level can reflect the severity of AIS, which was association with stroke subtype.

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“…(16) In our study, we found 63.3% of total subjects with ischemic stroke have high levels of hsCRP (>3 mg/L) and mean of hsCRP in total subjects are 10.5 mg/L ( Table 1) (18) On the other hand, only 22% of stroke patients had high CRP (>7 mg/L) levels in a study from Netherlands. (19) This variance may be explained partly by the different definitions of high CRP in various studies. In addition, cohort study of stroke patients with median of 10 days after stroke onset demonstrated an association between higher levels of IL-6, CRP and fibrinogen and an increased incidence of recurrent stroke.…”

Section: Research Subjectsmentioning

confidence: 99%

The Association of Plasma Fractalkine and Inflammation After Ischemic Stroke

et al. 2016

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BACKGROUND: Inflammation affects the brain after stroke with main functions to rapidly eliminate the source of the disturbance, remove damaged tissue and then restore tissue homeostasis. High sensitive C-reactive protein (hsCRP) is a sensitive marker of inflammation and tissue injury in the arterial wall, while fractalkine is a distinct chemokine that promotes inflammatory signaling after neuronal death on ischemic stroke. We aim to investigate the association of fractalkine with hsCRP as a marker of inflammation in ischemic stroke patients.METHODS: This study was designed as a cross-sectional study. Soon after patients with ischemic stroke admitted to hospital, plasma fractalkine and hsCRP concentrations were assesed. Subjects had to be at least 30 years old and maximum 30 days of stroke onset. High inflammation was defined as hsCRP value >3 mg/L.RESULTS: High fractalkine levels were found on 24 ischemic stroke patients (49%) and mean of fractalkine 0.719 ng/mL on patients with stroke onset <7 days was higher than patients with stroke onset 7-30 days. Low fractalkine levels (<0.527 ng/mL) were found on ischemic stroke patients with onset 7-30 days accompanied by high inflammation (hsCRP >3 mg/L), but no significant correlation between fractalkine and hsCRP (p=0.613).CONCLUSION: High inflammation and low plasma fractalkine profile was found after 7 days of onset in ischemic stroke patients. No significant correlation between fractalkine and hsCRP in ischemic stroke patients.KEYWORDS: CRP, fractalkine, inflammation, ischemic stroke

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C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death

Cited by 125 publications

References 30 publications

Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

The Association of Plasma Fractalkine and Inflammation After Ischemic Stroke

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