2011
DOI: 10.1373/clinchem.2011.169839
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C-Reactive Protein Induces Release of Both Endothelial Microparticles and Circulating Endothelial Cells In Vitro and In Vivo: Further Evidence of Endothelial Dysfunction

Abstract: BACKGROUND Inflammation is pivotal in atherosclerosis. A key early event in atherosclerosis is endothelial dysfunction. C-reactive protein (CRP), the prototypic marker of inflammation in humans, is a risk marker for cardiovascular disease, and there is mounting evidence to support its role in atherothrombosis. CRP has been shown to promote endothelial dysfunction both in vitro and in vivo. Emerging biomarkers of endothelial dysfunction include circulating endothelial cells (CECs) and endothel… Show more

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Cited by 67 publications
(39 citation statements)
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“…We tested several possibilities, including the MCP-1 stimulus always present during the TEM, mCRP, and TNF as a possible positive control. TNF induces MP production in human umbilical vein endothelial cultures [29], and CRP has been reported to induce MP shedding by aortic endothelial cells [30], but neither has been tested in microvascular endothelium. Treatment with mCRP almost doubled the number of MPs produced from microvascular endothelial cells, while MCP-1 alone had no effect, and TNF was as active as mCRP (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…We tested several possibilities, including the MCP-1 stimulus always present during the TEM, mCRP, and TNF as a possible positive control. TNF induces MP production in human umbilical vein endothelial cultures [29], and CRP has been reported to induce MP shedding by aortic endothelial cells [30], but neither has been tested in microvascular endothelium. Treatment with mCRP almost doubled the number of MPs produced from microvascular endothelial cells, while MCP-1 alone had no effect, and TNF was as active as mCRP (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…CRP has been proposed to play a pivotal role in vascular inflammation and dysfunction [19] . Meanwhile, a large body of evidence suggests that RAGE plays an important role in the development of atherosclerosis [20] .…”
Section: Discussionmentioning
confidence: 99%
“…Further, the concentration of CRP is positively correlated with the degree of obesity and inversely with insulin sensitivity [125]. Indeed, CRP, via NO deficiency, promotes ED by inducing the release of circulating endothelial cells and endothelial microparticles, which are the biomarkers of ED [126]. While CRP is a risk marker, studies demonstrate that CRP causes down regulation of eNOS by decreasing eNOS activity and NO bioactivity [127,128].…”
Section: Endothelial Dysfunctionmentioning
confidence: 99%