Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

Hyderali, Barkath Nisha; Kundabala, M

doi:10.1016/j.ejogrb.2015.05.005

Cited by 77 publications

(48 citation statements)

References 124 publications

(142 reference statements)

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“…Various studies have already suggested that oxidative stress and PCOS together lead to cardiovascular complications . Antioxidant supplements have been shown to ameliorate the negative effects of oxidative stress in PCOS .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there are an increasing number of studies examining the role of oxidative stress in PCOS and associated co‐morbidities. Previous reports suggested that increased oxidative stress and reduction in antioxidant defence mechanisms may also contribute to disease processes in PCOS and associated with conditions such as infertility, insulin resistance and increased CVD risk . Dynamic thiol disulphide homeostasis, a recently defined oxidative stress marker, has been shown to contribute to antioxidant protection, detoxification and apoptosis, and is also implicated in the pathogenesis of various disorders including diabetes and CVD …”

Section: Introductionmentioning

confidence: 99%

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The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

Özler

Öztaş

Tokmak

et al. 2015

Clinical Endocrinology

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Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case-control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age-matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA-IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0Á002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0Á001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405Á45 lmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1Á019, 95% CI: 1Á001-1Á036). In addition, a LAP index greater than 21Á54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1Á270, 95% CI: 1Á174-1Á374). ConclusionIn conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

Özler

Öztaş

Tokmak

et al. 2015

Clinical Endocrinology

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“…Therefore, the decrease of ∼ 50% of fasting insulin and HOMA-IR observed after dietary intervention was associated with the reduction of DNA damage, which might be related to an attenuated state of oxidative stress, commonly found elevated in PCOS women (regardless of excess weight) [56,57] . Our results also demonstrated an improvement in the hormonal profile, with reduction of hyperandrogenism, as reported in other studies [58,59] and even a positive correlation with the reduction of DNA damage.…”

Section: Discussionmentioning

confidence: 99%

Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk Factors in Overweight/Obese Women with Polycystic Ovary Syndrome

Soares¹,

Santos²,

Costa³

et al. 2016

Ann Nutr Metab

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Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m²) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients.

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“…Its etiopathophysiological core remains vague; however, gonadotropin-secretory alterations, androgen excess, insulin resistance and low-grade inflammation, in conjunction with the pivotal contribution of genetic and environmental parameters, are all involved in the interplay net of the syndrome (176,177). Recently, oxidative stress has also been highlighted as another potent modulator of PCOS (178,179).…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

Diamanti-Kandarakis

Papalou²,

Kandaraki

et al. 2017

European Journal of Endocrinology

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Nutrition can generate oxidative stress and trigger a cascade of molecular events that can disrupt oxidative and hormonal balance. Nutrient ingestion promotes a major inflammatory and oxidative response at the cellular level in the postprandial state, altering the metabolic state of tissues. A domino of unfavorable metabolic changes is orchestrated in the main metabolic organs, including adipose tissue, skeletal muscle, liver and pancreas, where subclinical inflammation, endothelial dysfunction, mitochondrial deregulation and impaired insulin response and secretion take place. Simultaneously, in reproductive tissues, nutrition-induced oxidative stress can potentially violate delicate oxidative balance that is mandatory to secure normal reproductive function. Taken all the above into account, nutrition and its accompanying postprandial oxidative stress, in the unique context of female hormonal background, can potentially compromise normal metabolic and reproductive functions in women and may act as an active mediator of various metabolic and reproductive disorders.

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Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

Cited by 77 publications

References 124 publications

The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk Factors in Overweight/Obese Women with Polycystic Ovary Syndrome

MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

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