In the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass.

Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index ≥25 and <39 kg/m²) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 ± 5.86 - pre diet vs. 17.15 ± 5.04 - post-diet; p < 0.001) and tail moment (20.47 ± 7.85 - pre diet vs. 14.13 ± 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients.

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Introduction: We aimed to investigate the impact of a diet in the inflammatory profile of overweight and/or obese women diagnosed with Polycystic Ovary Syndrome (PCOS). Methods: A study was conducted in Natal, Brazil selecting overweight/obese (BMI ≥25 and <39 kg/m 2) women (18-35 years old).). The inflammatory markers were dosed by chemiluminescence without immulitis equipment. Dietary recall questionnaires, repeated 24h. were collected at baseline and after twelve weeks of the intervention. Results: The Anthropometric indicators and clinical signs of Polycystic Ovarian Syndrome showed that women with PCOS 45% (n= 10) were overweight and 54.6% (n= 12) were obese. Regarding cardiovascular risk, 86.4% presented a risk of metabolic disorders and consequently an increase in cardiovascular disease After a 12-week intervention there was the improvement in the lipid profile weight, anthropometric, hormonal, and biochemical parameters. The Weight decreased 3.5% (~2 kg) was associated with significant reduction in BMI (28.9 ± 5.2 Kg/m 2), FSH (2.4 ± 0.9 mUI/mL), testosterone (129 ± 41 ng/dL), SHBG (115 ± 81.4 mmol/L) and a levels and ease in progesterone (1.89 ± 0.76). It was also noted a reduction of plasma insulin (5.5 ± 1.4 µUI/mL), HOMA-IR 0.9 ± 0.3 mol x µUI), QUICK (0.38 ± 0.02 and LDL-cholesterol levels (86 ± 0.01 mg/dL) as shown in table 4. The Profile of Inflammatory markers in the table 5 in women with polycystic ovarian syndrome. showed a decrease in hs-PCR (39.7 ± 7mg/L), TNF-α (5.3 ± 1.1 pg/mL) and IL-6 (2.3 ± 0.2 pg/mL). Conclusion: Inflammatory cytokines and inflammation indicators levels decreased after intervention in women with PCOS indicating the relevance of a nutritional approach in this group of patients.