The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome

Santos, Andrea; Soares, Nayara Pereira; Costa, Eduardo Caldas; Sá, Joceline Cássia Ferrezini de; Azevedo, George Dantas de; Lemos, Telma Maria Araújo Moura

doi:10.3109/09513590.2014.976546

Cited by 28 publications

(22 citation statements)

References 27 publications

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“…Several studies in the literature have evaluated changes in the inflammatory state in PCOS and documented an increase in CRP levels regardless of the BMI in patients with PCOS [1,3,8,9,20]. In the present study, levels of CRP were increased both in obese and lean patients with PCOS compared with the obese and lean controls.…”

Section: Discussioncontrasting

confidence: 35%

“…On the other hand, there is an ongoing debate as to which mediators may be increased in patients with PCOS. For instance, previous studies have documented increased levels of C-reactive protein (CRP) in patients with PCOS in support of this argument [1,8,9]. Imbalances between proinflammatory such as tumor necrosis factor a (TNF-a) and anti-inflammatory cytokines are argued to have an impact on PCOS [10].…”

Section: Introductionmentioning

confidence: 86%

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Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome

Aytan

Baştu

Demiral

et al. 2016

Gynecological Endocrinology

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This prospective study aimed to determine the status of circulating levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), IL-27, IL-35, IL-37, α-1 acid glycoprotein in patients with polycystic ovary syndrome (PCOS) compared with controls and to evaluate their relation with hyperandrogenism and obesity. Forty-eight patients with PCOS (29 obese, 19 lean) and 40 healthy controls (20 obese, 20 lean) were enrolled. CRP, TNF-α, IL-27, IL-35, IL-37, α-1 acid glycoprotein, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S) levels were measured. Levels of total testosterone, A4, DHEA-S were significantly higher in patients with PCOS than in controls both in the obese and lean groups, while levels of SHBG were significantly lower in all patients with PCOS than in all (p < 0.05). Free androgen index (FAI) values were significantly higher in all patients with PCOS than in all controls (all p < 0.05). Levels of CRP, TNF-α, α-1 acid glycoprotein were significantly increased in all patients with PCOS compared with all controls (all p < 0.001). FAI had a positive correlation with CRP, TNF-α, α-1 acid glycoprotein, a negative correlation with IL-27, IL-25, IL-37 (all p < 0.01). Body mass index had a negative correlation with IL-27, IL-35, IL-37, a positive correlation with α-1 acid glycoprotein, FAI (p < 0.05). The findings confirm the proinflammatory state of PCOS. Moreover, obesity along with PCOS significantly elevates the inflammatory status and hyperandrogenism.

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Section: Discussioncontrasting

confidence: 35%

Section: Introductionmentioning

confidence: 86%

Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome

Aytan

Baştu

Demiral

et al. 2016

Gynecological Endocrinology

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“…The pathophysiology of PCOS is heterogeneous and remains unresolved. However, in the PCOS pathogenesis the pivotal role of hyperinsulinemia and insulin resistance (IR) is highlighted [2,5,6]. IR is a factor linking PCOS and metabolic syndrome (MS).…”

Section: Introductionmentioning

confidence: 99%

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Pukajło

Łaczmański

Kolačkov

et al. 2015

Gynecological Endocrinology

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Irisin (Ir), a recently identified adipo-myokine, cleaved and secreted from the protein FNDC5 in response to physical activity, has been postulated to induce the differentiation of a subset of white adipocytes into brown fat and to mediate the beneficial effects on metabolic homeostasis. Metabolic syndrome (MS), a cluster of factors leading to impaired energy homeostasis, affects a significant proportion of subjects suffering from polycystic ovary syndrome (PCOS). The aim of our study was to investigate the relationship between Ir plasma concentrations and metabolic disturbances. The study group consisted of 179 PCOS patients and a population of 122 healthy controls (both groups aged 25-35 years). A subset of 90 subjects with MS was isolated. A positive association between Ir plasma level and MS in the whole group and in controls was found. In subjects with high adipose body content (>40%), Ir was higher than in lean persons (<30%). Our results showed a significant positive association between Ir concentration and android type of adipose tissue in the whole study group and in the control group. Understanding the role of Ir in increased energy expenditure may lead to the development of new therapeutics for obesity and obesity-related diseases.

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“…Many studies suggest that chronic infections are followed by increased levels of reactive oxygen species, myeloperoxidase, oxidative stress, in ammatory cytokines (such as IL-6 and TNF-α), high-sensitivity C-reactive protein (hs-CRP), adhesion molecules, and blood lymphocytes and monocytes, a process which plays an important role in the etiology and pathogenesis of PCOS. This cascade of pro-in ammatory incidents is proposed as a potential link between periodontal disease and PCOS (20)(21)(22). In a study, that examined the levels of anti-in ammatory cytokines in gingival crevicular uid (GCF), saliva and serum of women with PCOS and healthy women, it was shown that PCOS and gingivitis are synergistic with increased levels of IL-6 and TNF-α.16 (22).…”

Section: Introductionmentioning

confidence: 99%

“…This cascade of pro-in ammatory incidents is proposed as a potential link between periodontal disease and PCOS (20)(21)(22). In a study, that examined the levels of anti-in ammatory cytokines in gingival crevicular uid (GCF), saliva and serum of women with PCOS and healthy women, it was shown that PCOS and gingivitis are synergistic with increased levels of IL-6 and TNF-α.16 (22). In another study, the level of matrix metalloproteinase-8 in the saliva and serum of patients with periodontal disease and PCOS showed an increase compared to the healthy controls (17).…”

Section: Introductionmentioning

confidence: 99%

Assessment of gingival inflammation indexes and matrix metalloproteinase (MMP-9) in patients with polycystic ovarian syndrome compared to control group

Maboudi¹,

Shafizade²,

Amiri³

et al. 2020

Preprint

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Background: There is emerging evidence to support the link between polycystic ovarian syndrome (PCOS) and periodontal disease, but the mechanisms associated with these two diseases have not been clearly elucidated but relate to different aspects of inflammation. This study aimed to determine the gingival inflammation indexes and matrix metalloproteinase-9 (MMP-9) in patients with polycystic ovarian syndrome compared to control group.Methods: This is a case-control study in which 87 women referred to the Babol Clinic Private Hospital were divided into three groups: 26 women with PCOS diagnosed on the basis of Rotterdam criteria with gingivitis, 26 women with PCOS without gingivitis and 26 healthy women who were matched for age and body mass index. After recording the underlying variables, fasting saliva samples were taken from all participants in the morning before any periodontal intervention. The samples, which were transferred to Babol Molecular Cell Research Center under cold-chain conditions to measure the serum levels of MMP-9 using ELISA kits. Periodontal status was evaluated for Gingival index (GI), bleeding on probing (BOP), plaque index (PI). Analysis of variance was used to compare the results for the normal quantitative variables and Chi-square test was used to compare the qualitative variables. Significance level was considered less than 0.05.Results: The highest mean periodontal disease indexes (GI, BOP, PI) were observed in women with PCOS with gingivitis and then in women with PCOS without gingivitis and then in healthy women in control group (p <0.05). The mean salivary MMP-9 levels were significantly higher in PCOS women (388/37 ± 75.05) compared to the control group (166/25 ± 35/43). Even in PCOS patients with healthy gingiva (233.00± 47.76) had higher levels of salivary MMP-9 than the control group and this difference was significant (p <0.05)Conclusions: There is a positive association between periodontal disease and PCOS and that salivary MMP-9 levels are higher in PCOS women with and without gingivitis than healthy women. However, it is recommended that multicenter study with larger sample sizes are to be conducted to establish a clearer association.

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The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome

Abstract: In the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass.

Cited by 28 publications

References 27 publications

Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome

Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome

Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution

Assessment of gingival inflammation indexes and matrix metalloproteinase (MMP-9) in patients with polycystic ovarian syndrome compared to control group

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