C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma

Abstract

This retrospective analysis identified CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity.

Evaluation of inflammation-based prognostic scores in patients undergoing hepatobiliary resection for perihilar cholangiocarcinoma

“…Considering these observations, it is evident that CRP is the most important component of the systemic inflammatory response, as CRP level is incorporated only in the mGPS. Gerhardt et al [30] studied CRP levels in 98 patients with perihilar cholangiocarcinoma (23 resected and 75 unresected), and found that patients with a CRP level below 12 mg/L at the time of diagnosis had a significantly longer median survival than patients with higher CRP values (16.2 months vs 7.6 months, P = 0.009).…”

Prognostic molecular markers in cholangiocarcinoma: A systematic review

“…In 98 peri-hilar CCs, Gerhardt et al found an elevated CRP to be an independent predictor of worse survival (P=0.029) (121).…”

Systemic inflammatory response predicts postoperative outcome in patients with liver metastases from colorectal cancer

“…There is increasing evidence that a high level of serum CRP is also correlated with shorter survival in patients with gastrointestinal malignancies [25,26], including cancers of the esophagus [27,28], stomach [29], biliary system [30], and colo-rectum [8,24,31,32].…”