Systemic inflammatory response predicts postoperative outcome in patients with liver metastases from colorectal cancer

Ishizuka, Mitsuru; Kita, Junji; Shimoda, Mitsugi; Rokkaku, Kyu; Kato, Masato; Sawada, Tokihiko; Kubota, Keiichi

doi:10.1002/jso.21294

Cited by 42 publications

(30 citation statements)

References 35 publications

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“…The results of this study also showed that the combination of an elevated CRP concentration and hypoalbuminemia (GPS) was associated with cancer-specific survival after potentially curative resection in patients with colorectal cancer. The results of the present study in patients with primary operable colorectal cancer are consistent with the prognostic value of the GPS previously reported in patients with advanced colorectal cancer [2,10,11]. Moreover, in this study, GPS was predictive of cancer-specific survival in patients with stage II colorectal cancer.…”

Section: Discussionsupporting

confidence: 92%

“…It has also been shown that elevated circulating C-reactive protein (CRP) concentrations before surgery are associated with poor outcome after resection for colorectal cancer [7,8,9]. It is therefore of interest that the combination of hypoalbuminemia and an elevated CRP, as in the Glasgow Prognostic Score (GPS), has been reported to be useful for providing additional prognostic information in patients with advanced cancer [2,10,11]. However, there are few reports about the prognostic value of this combination in primary operable colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Glasgow Prognostic Score as a Prognostic Factor in Patients Undergoing Curative Surgery for Colorectal Cancer

Sugimoto¹,

Komiyama²,

Kojima³

et al. 2012

Dig Surg

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Background/Aims: Systemic inflammatory responses have been reported to be independent predictors of cancer-specific survival in colorectal cancer. The Glasgow Prognostic Score (GPS), which is an inflammation-based prognostic factor, is defined by the presence of elevated C-reactive protein and hypoalbuminemia. The purpose of this study was to estimate whether GPS can be a prognostic factor in patients undergoing curative surgery for colorectal cancers. Methods: We studied 166 patients with stage II (TNM classification) and 200 patients with stage III who had undergone curative surgery for colorectal cancer between 1999 and 2004. Univariate and multivariate analyses were performed to evaluate the relationship between clinicopathological factors and prognosis. Results: Among patients with stage II, location and GPS were independent factors on multivariate analysis. In particular, GPS was revealed to be the strongest factor in cancer-specific survival (HR: 7.43, 95% confidence interval, CI: 2.86–19.30, p < 0.0001). On the other hand, among patients with stage III, the number of metastatic lymph nodes was the only independent factor on multivariate analysis (HR: 1.14, 95% CI: 1.07–1.20, p < 0.0001). GPS was not a prognostic factor in cancer-specific survival in stage III. Conclusion: Among patients with stage II, GPS was predictive of cancer-specific survival.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Glasgow Prognostic Score as a Prognostic Factor in Patients Undergoing Curative Surgery for Colorectal Cancer

Sugimoto¹,

Komiyama²,

Kojima³

et al. 2012

Dig Surg

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show abstract

“…Using the original GPS (cut-off CRP value of 1.0 mg/dl), there were no GPS2 patients in the group undergoing secondary cytoreduction, but using the mGPS, 4 of 82 patients (5%) were mGPS2. Regarding the prognostic significance of GPS in multimodality therapy for advanced cancer, two recent reports showed that systemic inflammatory response, including GPS, predicts postoperative outcome in CRC patients with liver metastasis [25,26]. In these studies, the GPS immediately prior to hepatectomy was a prognostic indicator of survival in patients not receiving neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of a Systemic Inflammatory Response in Patients Undergoing Multimodality Therapy for Advanced Colorectal Cancer

et al. 2012

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Objectives: The inflammation-based Glasgow Prognostic Score (GPS) is associated with outcome in a variety of cancers. This study investigated whether a modified GPS (mGPS) could predict survival in patients undergoing multimodality therapy for advanced colorectal cancer (CRC). Methods: We enrolled 245 patients with advanced CRC who received chemotherapy. The mGPS was recorded prior to first-line chemotherapy and to cytoreductive therapy including secondary surgery and/or radiofrequency ablation. The prognostic significance of the mGPS was analyzed using Kaplan-Meier, univariate, and multivariate analyses. Results: In patients who received chemotherapy alone (n = 163), the mGPS prior to chemotherapy was an independent prognostic indicator of survival [odds ratio (OR) 1.858; 95% confidence interval (CI) 1.213–2.846; p = 0.0044]. In patients who also underwent cytoreductive therapy (n = 82), the mGPS decreased after chemotherapy in 22 patients (27%) and increased in 5 (6%). In these patients, the mGPS prior to cytoreductive therapy was an independent prognostic indicator of survival (OR 3.412; 95% CI 1.198–9.720; p = 0.0216), but the mGPS prior to chemotherapy was not. Conclusions: The mGPS is an independent prognostic indicator of survival in patients undergoing multimodality therapy for advanced CRC, if recorded at a relevant time point.

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“…It is well established that raised levels of inflammatory markers are associated with elevated serum lipids, particularly in LDLs (35)(36)(37). Furthermore, the presence of inflammation has been shown in a number of studies to be a predictor of clinical outcome in malignancy (38)(39)(40)(41). A number of in vivo studies have illustrated alteration in hepatic expression of nuclear receptors, LXR, FXR, PPAR, CAR, and PXR, involved in lipid handling in the presence of inflammation (42).…”

Section: Discussionmentioning

confidence: 99%

Pharmacometabonomic Profiling as a Predictor of Toxicity in Patients with Inoperable Colorectal Cancer Treated with Capecitabine

Backshall

Sharma

Clarke

et al. 2011

Clinical Cancer Research

110

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Systemic inflammatory response predicts postoperative outcome in patients with liver metastases from colorectal cancer

Abstract: GPS is able to classify patients with LM-CRC into three independent groups. Among the selected factors, CRP is considered an important and high sensitive predictor of postoperative death in such patients.

Cited by 42 publications

References 35 publications

Glasgow Prognostic Score as a Prognostic Factor in Patients Undergoing Curative Surgery for Colorectal Cancer

Glasgow Prognostic Score as a Prognostic Factor in Patients Undergoing Curative Surgery for Colorectal Cancer

Prognostic Significance of a Systemic Inflammatory Response in Patients Undergoing Multimodality Therapy for Advanced Colorectal Cancer

Pharmacometabonomic Profiling as a Predictor of Toxicity in Patients with Inoperable Colorectal Cancer Treated with Capecitabine

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