C-Reactive Protein Is Elevated 30 Years After Eclamptic Pregnancy

Hubel, Carl A.; Powers, Robert W.; Snaedal, Sunna; Gammill, Hilary S.; Ness, Roberta B.; Roberts, James M.; Arngrı́msson, Reynir

doi:10.1161/hypertensionaha.108.109934

Cited by 71 publications

(43 citation statements)

References 37 publications

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“…7 It has been suggested that the release of placental debris, microparticles, 8 and molecules secreted into the maternal blood flow might be responsible for the maternal response triggering systemic inflammation, endothelial lesions and subsequent symptoms. 9 In addition, vIUGR can be attributed to a reduction of the vascular flow towards the fetus interfering with the fetal growth.…”

Section: Combination Of Promoter Hypomethylation and Pdx1 Overexpressmentioning

confidence: 99%

Combination of promoter hypomethylation and PDX1 overexpression leads toTBX15decrease in vascular IUGR placentas

Chelbi¹,

Doridot²,

Mondon³

et al. 2011

Epigenetics

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Section: Combination Of Promoter Hypomethylation and Pdx1 Overexpressmentioning

confidence: 99%

Combination of promoter hypomethylation and PDX1 overexpression leads toTBX15decrease in vascular IUGR placentas

Chelbi¹,

Doridot²,

Mondon³

et al. 2011

Epigenetics

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“…From these data, the investigators con-cluded that factors that increase the risk for cardiovascular disease might also be linked to preeclampsia [15]. This was further supported by the finding that classic risk factors for cardiovascular disease in women with a history of preeclampsia including systolic and diastolic blood pressure, body mass index, and concentrations of cholesterol and triglycerides [10,16,17] were increased compared to women with uncomplicated pregnancies. In addition, Blaauw et al [12] found increased intima-media thickness (IMT) of femoral arteries measured by ultrasonography in women who had preeclampsia three months post partum.…”

Section: Discussionmentioning

confidence: 85%

Abnormal coronary artery angiography is not associated with adverse pregnancies outcomes

Heemskerk¹,

Ramanna²,

Bloemenkamp³

et al. 2012

OJOG

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Background: Recently, epidemiologic studies have suggested an association between pregnancy complications and the development of coronary artery disease later in life. The current study investigate the relation between obstructive coronary versus normal coronary angiographies and the prevalence of complications during pregnancy including preeclampsia, pregnancy induced-hypertension, low birth weight, and preterm birth. Methods: All consecutive women aged <55 year, who had coronary angiography were included. Based on angiography outcome, patients were classified as normal (controls: no stenosis, wall irregularity without stenosis, or minimal calcification present) or abnormal (subjects). A standard questionnaire was sent to all participating women. The questionnaires inquired into risk factors for coronary vascular disease, in particular history of hypertensive diseases, and specific obstetric history. The results were analyzed using the unpaired t-test, the Chi-squared test, and Pearson's correlation coefficients as appropriate. A significance level of P < 0.05 was used. Results: Of the 211 consecutive women aged <55 years, 62% (n = 131) had normal coronary angiography and 38% (n = 80) abnormal coronary angiography. We found no differences of reported pregnancy complications including preeclampsia, hypertension, low birth weight, and preterm birth (combined RR = 0.70, 95% C.I. = 0.38 -1.3) in case of abnormal coronary angiography compared to women with normal coronary angiography. The traditional risk factors hypercholesterolemia, tobacco use, and diabetes were identified as the major risk factors for developing cardiovascular disease, with a relative risk ranging from 4.2 -1.8. Conclusion: These data suggest that pregnancy complications are not an important denominator for cardiovascular disease.

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“…These differences are not fully explained by the higher BMI typical of women with a history of GDM. Studies of lipid profiles after pregnancies complicated by preeclampsia are consistent with increased atherogenesis risk, including consistently reported higher total cholesterol, LDL cholesterol, and triglycerides, although these differences are not always statistically significant Manten et al 2007;Hubel et al 2008;Laivuori et al 1996;Magnussen et al 2009;Romundstad et al 2010;Sattar et al 2003;Smith et al 2009). Associations of reduced HDL cholesterol after preeclampsia have been reported by some Magnussen et al 2009;Romundstad et al 2010;Smith et al 2009) but not all (Manten et al 2007;Laivuori et al 1996;Sattar et al 2003) studies.…”

Section: Cardiovascular Risk After Pregnancy Complicationsmentioning

confidence: 97%

“…After pregnancy, plasma C-reactive protein is elevated among women with prior eclampsia and indicated preterm births suggesting that systemic low-grade inflammation may link some adverse pregnancy outcomes and later CVD (Hastie et al 2011b;Hubel et al 2006). Several studies have documented higher C-reactive protein levels among women with a history of GDM (Heitritter et al 2005;Di Cianni et al 2007;Winzer et al 2004).…”

Section: Cardiovascular Risk After Pregnancy Complicationsmentioning

confidence: 99%

Pregnancy Characteristics and Women’s Cardiovascular Health

Fraser

Catov

Lawlor

et al. 2017

Handbook of Life Course Health Development

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Growing evidence indicates that women with a history of common pregnancy complications, including fetal growth restriction and preterm delivery (often combined as low birth weight), hypertensive disorders of pregnancy, and gestational diabetes are at increased risk for cardiovascular disease later in life. Here we review the associations of parity and these four pregnancy complications with cardiovascular morbidity and mortality and the role of cardiovascular risk factors before, during, and after pregnancy complications in explaining these associations. We explore the implications of these findings for research in life course health science and policy intended to avoid or mitigate these pregnancy-related effects. Findings suggest consistent and often strong associations of pregnancy complications with latent and future cardiovascular disease. Many pregnancy complications appear to be preceded by subclinical vascular and metabolic dysfunction, suggesting that the complications may be useful markers of latent high-risk cardiovascular trajectories. Pregnancy complications may be useful in identifying high-risk women, at a relatively early stage in their life course for screening, prevention, and treatment of cardiovascular disease, the leading cause of morbidity and mortality among women.

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C-Reactive Protein Is Elevated 30 Years After Eclamptic Pregnancy

Cited by 71 publications

References 37 publications

Combination of promoter hypomethylation and PDX1 overexpression leads toTBX15decrease in vascular IUGR placentas

Combination of promoter hypomethylation and PDX1 overexpression leads toTBX15decrease in vascular IUGR placentas

Abnormal coronary artery angiography is not associated with adverse pregnancies outcomes

Pregnancy Characteristics and Women’s Cardiovascular Health

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