C–Reactive Protein Levels and Radiation–Induced Mucositis in Patients With Head–and–Neck Cancer

Ki, Yongkan; Kim, Wontaek; Nam, Jiho; Kim, Dong-Hyun; Park, Dahl; Kim, Dong-Won

doi:10.1016/j.ijrobp.2008.11.012

Cited by 28 publications

(28 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased Creactive protein levels have been reported in patients with head and cancer during and shortly after radiotherapy. 8,35,36 Furthermore, elevated levels of interleukin-1ß, interleukin-6, interleukin-8, and C-reactive protein were found in patients with head and neck cancer before and shortly after treatment with induction chemotherapy followed by chemoradiation. 17 In the latter study, posttreatment levels of inflammatory markers were not significantly higher than pretreatment levels.…”

Section: Discussionmentioning

confidence: 98%

“…Increased inflammatory activity during radiotherapy has been associated with radiation-induced mucositis. 35,37 More knowledge concerning the level and duration of inflammatory activity per treatment modality is needed. Furthermore, more insight in the effect of inflammatory activity on energy expenditure and protein breakdown in patients with head and neck cancer is needed.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in nutritional status and dietary intake during and after head and neck cancer treatment

et al. 2010

View full text Add to dashboard Cite

Background.The purpose of this study was to test whether nutritional status of patients with head and neck cancer changes during and after treatment.Methods.Nutritional status (including body weight, lean mass, and fat mass) and dietary intake were assessed in 29 patients with head and neck cancer. Patients were assessed 1 week before, and 1 and 4 months after treatment (radiotherapy, either alone or combined with chemotherapy or surgery).Results.During treatment, body weight (−3.6 ± 5.3 kg; p = .019) and lean mass (−2.43 ± 2.81 kg; p = .001) significantly declined. Patients with sufficient intake (≥35 kcal and ≥1.5 grams protein/kg body weight) lost less body weight and lean mass than patients with insufficient intake (mean difference, −4.0 ± 1.9 kg; p = 0.048 and −2.1 ± 1.0 kg; p = .054, respectively). After treatment, only patients with sufficient intake gained body weight (2.3 ± 2.3 kg) and lean mass (1.2 ± 1.3 kg).Conclusion.Patients with head and neck cancer fail to maintain or improve nutritional status during treatment, despite sufficient intake. © 2010 Wiley Periodicals, Inc. Head Neck, 2011

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Changes in nutritional status and dietary intake during and after head and neck cancer treatment

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Mohammed et al (2012) reported from their study that CRP levels were significantly elevated by 6 weeks in a radiation-dose-dependent manner. Ki et al (2009) also observed a correlation between the presence of acute mucositis and CRP levels. They were able to determine CRP levels together with mucosal reactions evaluation during or after radiotherapy to provide further information on radiation-induced mucositis.…”

Section: Mucositismentioning

confidence: 63%

“…Chemotherapeutic agents that are known to be mucotoxic include methotrexate, etoposide, cyclophosphamide, 5-fluorouracil, doxorubicin, melphalan, and cytosine arabinoside (Pico et al 1998). CRP has been shown to be elevated in radiation-induced mucositis in patients with head and neck cancer (Ki et al 2009;Mohammed et al 2012). Mohammed et al (2012) reported from their study that CRP levels were significantly elevated by 6 weeks in a radiation-dose-dependent manner.…”

Section: Mucositismentioning

confidence: 99%

“…They were able to determine CRP levels together with mucosal reactions evaluation during or after radiotherapy to provide further information on radiation-induced mucositis. A change of the mean CRP level was correlated with progression of mean grade of mucositis according to radiation fraction number (Ki et al 2009). The inflammation observed in mucositis does not necessarily have to be elicited by microbes, as the mucosal barrier disruption alone seems to be able to induce a systemic inflammatory response, evidenced by elevated CRP levels and fever (van der Velden et al 2009).…”

Section: Mucositismentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory Markers in Patients after Hematopoietic Stem Cell Transplantation

Sjøqvist

Snarski

2013

Arch. Immunol. Ther. Exp.

View full text Add to dashboard Cite

Infections are one of the most common complications after hematopoietic stem cell transplantation (HSCT). Diagnosis is established by analysis of clinical symptoms and results of diagnostic tests such as biochemical panels, microbiological cultures, and visual diagnostics. As the microbiological cultures yield positive results in only some patients and visual diagnostics might miss the infectious source, the diagnosis and proper treatment often depends on clinical assessment supported by laboratory test results. The most commonly used makers of inflammation include C-reactive protein and procalcitonin. However, these tests have serious limitations when used in patients after HSCT. The drugs used in conditioning, neutropenia, and graft-versus-host disease might influence the results of the tests and misguide the physician. In this review, we summarize the current knowledge on profiles of expression of basic markers of inflammation used in clinical practice in patients after HSCT.

show abstract

Acute‐phase response reactants as objective biomarkers of radiation‐induced mucositis in head and neck cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

C–Reactive Protein Levels and Radiation–Induced Mucositis in Patients With Head–and–Neck Cancer

Cited by 28 publications

References 7 publications

Changes in nutritional status and dietary intake during and after head and neck cancer treatment

Changes in nutritional status and dietary intake during and after head and neck cancer treatment

Inflammatory Markers in Patients after Hematopoietic Stem Cell Transplantation

Acute‐phase response reactants as objective biomarkers of radiation‐induced mucositis in head and neck cancer

Contact Info

Product

Resources

About