C-reactive protein, Neutrophil/lymphocyte ratio, Platelet/lymphocyte ratio, Monocyte/lymphocyte ratio among adolescents with anorexia nervosa: A preliminary study

Abstract

Background: Inflammatory cytokines are involved in the pathophysiological process of various mental disorders.CRP,Neutrophil/lymphocyte (NLR),monocyte/lymphocyte (MLR),platelet/lymphocyte (PLR) are commonly used and readily available inflammatory markers in clinic，However, their results in Anorexia Nervosa (AN) are few and inconsistent. Methods: We did an exploratory analysis, including (1) comparison of plasma CRP concentration and NLR, PLR, and MLR values in 53 AN patients and 55 healthy controls, and (2) correlation of age,body mass index (BMI),and disease course with CRP concentration and NLR,PLR,and MLR values (after logarithmic transformation).To explore the relationship between malnutrition and inflammatory indicators. Results: The plasma levels of CRP and MLR in AN Patients were significantly lower than those in the normal control group, while NLR and PLR were significantly increased. In all researchers. CRP and MLR were positively correlated with BMI, while NLR and PLR were negatively correlated with BMI. However, such correlation was only correlated with CRP in AN patient, positively correlated with age and BMI, and negatively correlated with the course of disease. Conclusions: The CRP level was negatively correlated with the course of disease in AN patient. The course of disease was independent risk factor for CRP level in AN patients.