2021
DOI: 10.1016/j.micpath.2021.105136
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C-terminal-truncated hepatitis B virus X protein promotes hepatocarcinogenesis by activating the MAPK pathway

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Cited by 12 publications
(7 citation statements)
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“…In recent years, several studies suggest that the occurrence of HBILC and HCC is related to the abnormalities of ERK1/2, p38 MAPK, and JNK1 sub-pathways. 11,[27][28][29] This suggests that the occurrence and development of HBILC and HCC are closely related to the abnormalities of MIF, ERK1/2, p38 MAPK, and JNK1. In the early stage of this study, it was found that hepatocellular carcinoma and its adjacent tissues highly expressed MIF and ERK1/2, suggesting that the occurrence of hepatocellular carcinoma is closely related to the expression of these two proteins.…”
Section: Discussionmentioning
confidence: 96%
“…In recent years, several studies suggest that the occurrence of HBILC and HCC is related to the abnormalities of ERK1/2, p38 MAPK, and JNK1 sub-pathways. 11,[27][28][29] This suggests that the occurrence and development of HBILC and HCC are closely related to the abnormalities of MIF, ERK1/2, p38 MAPK, and JNK1. In the early stage of this study, it was found that hepatocellular carcinoma and its adjacent tissues highly expressed MIF and ERK1/2, suggesting that the occurrence of hepatocellular carcinoma is closely related to the expression of these two proteins.…”
Section: Discussionmentioning
confidence: 96%
“…The proliferation of HaCaT cells was identified utilizing Cell Counting Kit-8 (CCK-8; Dojindo Molecular Technologies, Tokyo, Japan) [ 44 ]. Succinctly, 2 × 10 3 cells were placed in triplicate in 96-well plates and subsequently cultured in L-DMEM medium supplemented with (25, 30) μM glucose (Sigma-Aldrich) and 2% (w/v) FBS, or different concentrations of exosomes (0, 500, 1,000, 2,000 ng/ml).…”
Section: Methodsmentioning
confidence: 99%
“…In addition, HBx mutants, particularly C-terminally truncated HBx (ctHBx), also play a multifunctional carcinogenic role in the development of HBV-associated HCC, such as promoting cell cycle progression, increasing cell migration, and regulating the cell cycle and apoptosis. In vitro study suggested that ctHBx promoted the formation and development of HCC via cell cycle-related target proteins cell division cycle 25C (cdc25C) and p53 downstream of MAPK pathway [ 19 , 20 ].…”
Section: Hbx Role In Hepatocarcinogenesismentioning
confidence: 99%
“…HBx one of viral factors that strongly triggers HCC carcinogenesis, as suggested by its significantly higher expression in HBV-related HCC as compared to the first phase of viral infection [15,16]. HBx localization in the cytoplasm of cells, enable it to interact with and modulate various signal transduction pathways of the cells including mitogen-activated protein kinase (MAPK), Src-dependent phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), kinase C signalling cascades, rat sarcoma virus (RAS), rapidly accelerated fibrosarcoma (RAF), Janus kinase-signal transducer and activator of transcription (JAK-STAT), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and focal adhesion kinase [17,18]. The transactivation of these cellular signaling molecules can all lead to more proliferation of hepatocytes (Table 1).…”
Section: Signal Transduction and Cell Cycle Progressionmentioning
confidence: 99%