C‑type lectin family XIV members and angiogenesis: A review

Abstract

The growth and metastasis of tumors is dependent on angiogenesis. C-type lectins are carbohydrate-binding proteins with a diverse range of functions. The C-type lectin family XIV members are transmembrane glycoproteins, and all four members of this family have been reported to regulate angiogenesis, although the detailed mechanism of action has yet to be completely elucidated. They interact with extracellular matrix proteins and mediate cell-cell adhesion by their lectin-like domain. The aim of the present study was to summarize the available information on the function and mechanism of C-type lectin family XIV in angiogenesis and discuss their potential as targets for cancer therapy. Contents 1. Introduction 2. C-type lectin family XIV 3. CLEC14A 4. Thrombomodulin 5. CD93 6. Endosialin 7. Conclusions and prospects

Serum ROBO4 and CLEC14A: preliminary evaluation as diagnostic and progression biomarkers in colorectal cancer patients

“…In the recent years, there has been increasing interest in identi cation of CRC with the use of noninvasive biomarkers [8]. The expression of ROBO4 and CLEC14A proteins in tumor neovasculature makes these molecules a potential target for use as a diagnostic and prognostic indicators of cancer, including CRC [17,23,24].…”

“…It was revealed that blocking anti-ROBO4/CLEC14 antibodies induced reduction of the formation of new vessels and led to inhibition of cancer mass [25,31]. Currently, the pro-angiogenic properties of CLEC14A and its involvement in tumor growth are well documented [24,25]. For example, the CLEC14A protein promotes lopodia formation and activates cell migration, which is detrimental for tumor cell proliferation [15].…”

Serum ROBO4 and CLEC14A: preliminary evaluation as diagnostic and progression biomarkers in colorectal cancer patients

“…C-type lectin domain family 14 member A (CLEC14A) is considered to be a TEM due to its overexpression in tumor vasculature, compared to adjacent nontumor blood vessels. High expression of CLEC14A was observed in head and neck squamous cell carcinoma, breast cancers, and clear cell renal cell carcinoma [23,24]. Additionally, studies with CLEC14A (-/-) mice proved the promoting role of CLEC14A in tumor growth [24].…”

“…High expression of CLEC14A was observed in head and neck squamous cell carcinoma, breast cancers, and clear cell renal cell carcinoma [23,24]. Additionally, studies with CLEC14A (-/-) mice proved the promoting role of CLEC14A in tumor growth [24].…”

Genetic variance and plasma concentration of CD93 is associated with cardiovascular mortality: Results from a 6.7‑year follow‑up of a healthy community‑living elderly population

“…It has also been reported that in patients with colorectal cancer, the level of CD93 is higher compared to a normal reference population (7). An important association between CD93 and angiogenesis that might influence tumour growth has been discussed in the literature (8). In an interesting review by Khan et al (9), the authors also discuss the relationship between CD93 and thrombomodulin, which has a central position in the coagulation cascade.…”