C13orf18 and C1orf166 (MULAN) DNA Genes Methylation are Not Associated with Cervical Cancer and Precancerous Lesions of Human Papillomavirus Genotypes in Iranian Women

Sohrabi, Amir; Samiee, Siamak Mirab; Farzami, Marjan Rahnamaye; Rafizadeh, Mitra; Akhavan, Setareh; Hashemi-Bahremani, Mohammad; Modarresl, Mohammad Hossein

doi:10.7314/apjcp.2014.15.16.6745

Cited by 16 publications

(14 citation statements)

References 30 publications

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“…The authors suggested that these pro-apoptotic or growth inhibition effects of GIDE may account for its absence in tumor cells. In addition, another recent study demonstrated that MUL1 DNA methylation is a potential biomarker in Iranian females with cervical intraepithelial neoplasia and dysplasia [ 25 ]. In the case of HNC, the most common risk factors, such as cigarette smoking or alcohol use, may induce MUL1 DNA methylation, ultimately leading to MUL1 suppression in the human HNC cell lines (Figure 2B ).…”

Section: Discussionmentioning

confidence: 99%

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer

Kim

Kang

et al. 2015

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Recent research on non-thermal plasma (NTP, an ionized gas) has identified it as a novel cancer therapeutic tool. However, the molecular mechanism remains unclear. In this study, we demonstrated NTP induced cell death of head and neck cancer (HNC) through the AKT ubiquitin–proteasome system. NTP increased the gene expression of mitochondrial E3 ubiquitin protein ligase 1 (MUL1), an E3 ligase for AKT, and NTP-induced HNC cell death was prevented by MUL1 siRNA. We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS. Furthermore, we optimized and manufactured a new type of NTP, a liquid type of NTP (LTP). In syngeneic and xenograft in vivo tumor models, LTP inhibited tumor progression by increasing the MUL1 level and reducing p-AKT levels, indicating that LTP also has an anti-cancer effect through the same mechanism as that of NTP. Taken together, our results suggest that NTP and LTP have great potential for HNC therapy.

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Section: Discussionmentioning

confidence: 99%

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer

Kim

Kang

et al. 2015

Oncotarget

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“…More than 200 Human Papillomavirus (HPV) genotypes have been detected, approximately 40 of which can infect the genital tract. Infection with highrisk HPV is considered a major cause of cervical cancer (1,2). Based on WHO guidelines, approximately sixteen HPV genotypes have been diagnosed in laboratories (HPVs 6,11 [Low Risks], 16,18,31,33,35,39,45,51,52,56,58,59,66,68 [High Risks]).…”

Section: Introductionmentioning

confidence: 99%

Cervical Cancer and Genital Infections: Assessment of Performance and Validation in Human Papillomavirus Genotyping Assays in Iran, its Neighbouring Countries and Persian Gulf Area

Sohrabi¹,

Hajia²

2017

Iran J Pathol

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Background: The accuracy of diagnostic assays in Human Papillomavirus (HPV) genital infection and cervical cancer has remained a clinical challenge in diagnosis. Evidence indicates that a large proportion of cervical cancer can be prevented through organized care for HPV and testing. Countries with low per capita income, such as Iran and its neighbours, have no national organized program for cervical cancer screening and vaccination. The aim of this study was to review recent published papers in this region for evaluating the efficacy of released data regarding HPV genotyping system in genital infections and cervical cancer Methods: Investigating various medical search engines retrieved 46 reports, mostly after 2010, consisting of either home brew protocols or commercial technologies in this field. Results: Summarized results demonstrated that except a few cases, all reports were limited studies performed in confined populations focusing on attending patients at clinics for regular checkups. In the present study, 52.8% of papers were from Iran and the rest belonged to other countries. The rate of HPV infection was reported in the range of 0.62% to 25% in the normal population, while it varied from 18.75% to 100% in females with cervical cancer. In HPV genotyping surveys, only 26.1 % (12/46) of reports had validated and World Health Organization (WHO) proficient procedures. Also, multiple infections were not mentioned in 56.52% (25/46) of researches. Conclusions: Employing reliable genotyping methods is the best way for regular screening of cervical cancer related to HPV and precancerous diseases in females of these areas. The focus of most surveys was to come up with the best national policies for establishing a preventive program in Iran and Persian Gulf area.

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“… 24 Epigenetic and genetic polymorphisms patterns as diagnostic biomarker and HPV genotypes detection can be used for determining appropriate treatment strategy for early stages of cervical cancer and increase survival in cervical carcinogenesis. 9 , 25 Persistent high risk-HPV genotypes with other STIs, environmental and host genetic factors may play critical roles in further malignant conversion of cervical epithelium and genital areas.…”

Section: Discussionmentioning

confidence: 99%

Characterization of JAK2 V617F (1849 G > T) Mutation in Cervical Cancer Related to Human Papillomavirus and Sexually Transmitted Infections

Abdolmaleki

Sohrabi

2018

J Cancer Prev

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BackgroundHuman papillomavirus (HPV) genotypes that infect the genital tract play a main etiologic role in cervical cancer progression. Other environmental factors, such as sexually transmitted diseases and the host genetic pattern, contribute to infection persistence of the uterus and cervical epithelium in sustaining their malignancy. The Janus kinase 2 is a non-receptor tyrosine kinase in cell signaling process of tumor genesis. In the present study, JAK2 V167F mutation was distinguished in women with sexually transmitted infections, such as Herpes simplex virus 2, Chlamydia trachomatis and Mycoplasma genitalium and cervical cancer.MethodsThis case-control survey was performed on 195 liquid based cytology of women specimens. Fifty, 98, and 47 samples were from women with known cervical cancer, HPV positive and HPV negative, respectively. Single nucleotide polymorphism analysis, sexually transmitted infections detection and HPV genotyping were carried out using approved PCR- RFLP, in-house multiplex TaqMan Real Time PCR and the reverse dot blot hybridization assay.ResultsHPVs 6, 16, 18, 11, 31, and 51 were the most common genotypes. The prevalence rate of multiple HPV genotypes was 46.0% to 10.1%. Analysis of JAK2 V617F (1849 G > T) showed that prevalence of mutation was GG (65.1%), GA (34.9%), and TT (0%), respectively. There were no statistically significant differences between this mutation and variables of population survey (P ≥ 0.05).ConclusionsThe molecular epidemiology study on the genetic polymorphisms, i.e., JAK2 V617F and other single nucleotide polymorphisms as a diagnostic tool is necessary for cancer screening and prophylactic programs.

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C13orf18 and C1orf166 (MULAN) DNA Genes Methylation are Not Associated with Cervical Cancer and Precancerous Lesions of Human Papillomavirus Genotypes in Iranian Women

Cited by 16 publications

References 30 publications

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer

Cervical Cancer and Genital Infections: Assessment of Performance and Validation in Human Papillomavirus Genotyping Assays in Iran, its Neighbouring Countries and Persian Gulf Area

Characterization of JAK2 V617F (1849 G > T) Mutation in Cervical Cancer Related to Human Papillomavirus and Sexually Transmitted Infections

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